|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Abnormal expression of the IL-6 gene has been suggested to be involved in the pathogenesis of a variety of diseases, especially rheumatoid arthritis, Castleman's disease, mesangial proliferative glomerulonephritis, multiple myeloma and Kaposi's sarcoma.
|
1643291 |
1992 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells.
|
8283061 |
1994 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Four virus proteins similar to two human macrophage inflammatory protein (MIP) chemokines, interleukin-6 (IL-6), and interferon regulatory factor (IRF) are encoded by the Kaposi's sarcoma-associated herpesvirus (KSHV) genome. vIL-6 was functional in B9 proliferation assays and primarily expressed in KSHV-infected hematopoietic cells rather than KS lesions.
|
8939871 |
1996 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
|
10361100 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.
|
10364379 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells.
|
10628804 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Cellular tropism and viral interleukin-6 expression distinguish human herpesvirus 8 involvement in Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease.
|
10196314 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Elevated levels of circulating interleukin-6, a cytokine that plays a central role in KS, were found in RFHVMm-viraemic animals.
|
10073709 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6.
|
10779772 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that IL6 promoter genotypes associated with altered gene expression are risk factors for development of KS.
|
11001912 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
J Virol 1997;71:4187-4192; Nicholas J, Ruvolo VR, Burns WH, Sandford G, Wan X, Ciufo D, Hendrickson SB, Guo HG, Hayward GS, Reitz MS. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.
|
10738139 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While vCYC (AKS 6 of 6; CKS 3 of 3), vMIP-I (AKS 5 of 6, CKS 3 of 3), vBCL2 (AKS 6 of 6; CKS 3 of 3), and vIRF1 (AKS 5 of 6, CKS 3 of 3) transcripts were detected in both AKS and CKS, vGCR and HIV-1 Tat were expressed only in AKS samples (vGCR: AKS 3 of 6, CKS 0 of 3; Tat: AKS 4 of 6, CKS 0 of 3). vMIPII, vCBP, and vIL6 expression were not detected in any KS samples.
|
10662620 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases.
|
10861641 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue.
|
11274637 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colocalization of the viral interleukin-6 with latent nuclear antigen-1 of human herpesvirus-8 in endothelial spindle cells of Kaposi's sarcoma and lymphoid cells of multicentric Castleman's disease.
|
11172301 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Preincubation with recombinant human IL-6 or OSM sensitized KS in a dose dependent manner.
|
11380243 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
|
11264189 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
|
12176919 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several groups have reported that vIL-6 is expressed from the HHV-8 genome at higher levels in PEL and MCD lesions than in KS lesions.
|
12134031 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
|
12176919 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-4, a cytokine with pleiotropic effects, suppresses IL-6 in vivo and modestly inhibits AIDS-KS-derived cells in vitro.
|
12513914 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways.
|
12776188 |
2003 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6.
|
14672670 |
2004 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to the HHV-8 infection, the interleukin-6 promoter polymorphism G-174C is associated with a risk of development of KS in renal transplant recipients.
|
15154666 |
2004 |