|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Angiogenesis and hematopoiesis induced by Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6.
|
10361100 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesviral IL-6 and human IL-6 open reading frames contain miRNA binding sites and are subject to cellular miRNA regulation.
|
21984125 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Detectable KSHV VL and elevated IL-6 levels are present in a subset of children with KS.
|
30204240 |
2019 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A rhesus macaque rhadinovirus related to Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 encodes a functional homologue of interleukin-6.
|
10364379 |
1999 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The genome of human herpes virus 8, which is associated with Kaposi's sarcoma, encodes proteins with similarities to cytokines and chemokines including a homologue of IL-6.
|
10779772 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral IL-6 is also considered to contribute significantly to HHV-8-associated pathogenesis, since vIL-6 can promote cell proliferation, cell survival, and angiogenesis that are characteristic of HHV-8-associated Kaposi's sarcoma, PEL and multicentric Castleman's disease (MCD), in addition to proinflammatory activities observed in MCD-like "Kaposi's sarcoma-associated herpesvirus-induced cytokine syndrome."
|
30541844 |
2019 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Among downstream genes, two specific metalloproteases, ADAMTS1 and 9, are strongly expressed in AIDS-KS tissues and contribute to KSHV-infected endothelial cell invasiveness through up-regulation of IL-6 and VEGF.
|
26675551 |
2016 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that IL6 promoter genotypes associated with altered gene expression are risk factors for development of KS.
|
11001912 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pretreatment of KS cells with poly (I:C) for 24 h followed by removal of the poly (I:C) led to high levels of IL-6 secreted into medium that induced proliferation in KS cells.
|
8283061 |
1994 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the viral interleukin-6 homolog from Kaposi sarcoma-associated herpesvirus is also sufficient to induce significant D6 upregulation both in vitro and in vivo, and Kaposi sarcoma and primary effusion lymphoma cells demonstrate high levels of D6 expression.
|
23479571 |
2013 |
|
Kaposi Sarcoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The Kaposi's sarcoma-associated herpesvirus viral interleukin 6 gene affects metastasis and expression of B cell markers in a murine xenograft model.
|
30265712 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
J Virol 1997;71:4187-4192; Nicholas J, Ruvolo VR, Burns WH, Sandford G, Wan X, Ciufo D, Hendrickson SB, Guo HG, Hayward GS, Reitz MS. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.
|
10738139 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While vCYC (AKS 6 of 6; CKS 3 of 3), vMIP-I (AKS 5 of 6, CKS 3 of 3), vBCL2 (AKS 6 of 6; CKS 3 of 3), and vIRF1 (AKS 5 of 6, CKS 3 of 3) transcripts were detected in both AKS and CKS, vGCR and HIV-1 Tat were expressed only in AKS samples (vGCR: AKS 3 of 6, CKS 0 of 3; Tat: AKS 4 of 6, CKS 0 of 3). vMIPII, vCBP, and vIL6 expression were not detected in any KS samples.
|
10662620 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates human interleukin-6 gene expression.
|
12176919 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed a trend toward decreased IL-6 after omega-3 supplementation specific to Kaposi sarcoma patients (P = 0.08).
|
29381560 |
2018 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our novel finding of the huIL-6 induction by vIL-6 indicates that vIL-6 may play a significant role in the pathogenesis of HHV-8 associated diseases.
|
10861641 |
2000 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several groups have reported that vIL-6 is expressed from the HHV-8 genome at higher levels in PEL and MCD lesions than in KS lesions.
|
12134031 |
2002 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The detection of vIL-6--positive lymphoid cells in bone marrow suggests a homing for HHV-8--infected elements in this tissue.
|
11274637 |
2001 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus encoded vFLIP induces cellular IL-6 expression: the role of the NF-kappaB and JNK/AP1 pathways.
|
12776188 |
2003 |
|
Kaposi Sarcoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Molecular mechanisms for viral mimicry of a human cytokine: activation of gp130 by HHV-8 interleukin-6.
|
14672670 |
2004 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.
|
17483315 |
2007 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Kaposi's sarcoma herpesvirus (KSHV) microRNA K12-1 functions as an oncogene by activating NF-κB/IL-6/STAT3 signaling.
|
27166260 |
2016 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Viral interleukin-6: role in Kaposi's sarcoma-associated herpesvirus: associated malignancies.
|
21767154 |
2011 |
|
Kaposi Sarcoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
By immunostaining, mesothelioma cells expressed interleukin-6 and platelet-derived growth factor, which are important for survival of Kaposi's sarcoma cells.
|
10628804 |
1999 |