|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a stratified analysis, a highly significant association between the -1082 AA IL-10 genotype and the steroid dependency was observed in IBD (p < 0.0001), contributing both UC (p = 0.004) and CD (p = 0.003) to this association.
|
16573780 |
2006 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL-10 polymorphisms contribute to susceptibility to CD in Spanish population.
|
16043989 |
2005 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Increasing evidence indicates that IL-10 plays an important role in both the onset and development of auto-immune diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren's syndrome (SS), multiple sclerosis (MS), Crohn's disease (CD), and psoriasis.
|
24639111 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Additionally, we show that T1D risk alleles residing at the PTPN22, IL27, IL18RAP and IL10 loci protect against CD.
|
20176734 |
2010 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A Gly15Arg mutation in the leader sequence of IL-10 was found in a multiple CD-affected family.
|
12825869 |
2003 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data indicate that the NOD2fs mutation results in a loss-of-function phenotype in human myeloid DC and imply decreased immune regulation by IL-10 as a possible mechanism for this mutation in CD.
|
16461743 |
2006 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The genetic determination of the defense mechanisms in CD appears to be associated with the polymorphism of the Hsp70-2 gene rather than that of the CD14 or IL-10 genes.
|
16165702 |
2005 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the association of polymorphisms in the promoter region of the IL-10 gene with the risk of inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).
|
24407599 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, trials of daily systemic interleukin-10 administration in patients with Crohn's disease have reported only a modest clinical response.
|
11683684 |
2001 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) that affect IL-10 production, such as rs1800896 (G/A) at position -1082 and rs1800871 (C/T) at position -819 in the promoter region of the IL10 gene, have been associated with CD and/or UC, but the results were inconsistent.
|
27558476 |
2016 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Hydrodynamic procedure efficiently delivers the IL10 gene to the human colon, achieving levels of tissue protein expression high enough to mediate pharmacological effects with interest in controlling immune response in patients with Crohn's disease.
|
28708803 |
2017 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
SEW2871 treatment ameliorates established experimental colitis in IL-10(-/-) mice, which may provide a new therapeutic approach for human CD therapy.
|
24611843 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In Tunisian population, the 3020insC insertion in NOD2/CARD15 gene is a marker of susceptibility to CD, while the A allele at position -627 in the IL-10 promoter increases the risk of CD ileal location and severe disease presentation.
|
19184348 |
2009 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Intracellular IL-10 expression by CD4<sup>+</sup> T-cell subsets in the inflamed guts of patients with IBD (Crohn disease or ulcerative colitis) was compared with that in cells from noninflamed control subjects.
|
29369775 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
LHGDN |
Crohn's disease patients receiving steroids had a higher secretion rate of RANTES and IL-10.
|
16911685 |
2006 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Defective IL-10 production in patients with Crohn's disease bearing loss of function mutations of NOD2 may lead to overwhelming inflammation due to a subsequent Th1 bias.
|
15879155 |
2005 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Levels of tumor necrosis factor-α, interleukin (IL)-1β, and IL-17 were higher, whereas IL-10 was lower in CD compared with controls.
|
24412990 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest the overexpressions of TNFalpha and IFNgamma in CD, and less producibility of IL-10 against these cytokine might lead to development of severe CD.
|
10719056 |
2000 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The IL-10 -819C/T and -592C/A polymorphisms contribute to susceptibility to UC, but IL-10 -1082G/A polymorphism neither associated with CD nor UC.
|
24128120 |
2014 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease.
|
30776076 |
2019 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported that low IL-10 mRNA levels in intestine are associated with a poor response to glucocorticoids in active Crohn's disease.
|
26090671 |
2015 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The logistic regression analysis has indicated that low expression levels of IL-2 and IL-10, together with higher ASCA IgG titers were independently associated with penetrating/stricturing CD.
|
23014361 |
2013 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease.
|
16716759 |
2006 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Expressions of GRAIL mRNA and protein in CD4+ T cells were investigated in the peripheral blood and mucosal tissues of patients with CD, mice with dextran sodium salt (DSS)-induced colitis, and Il-10-deficient mice.
|
24356810 |
2014 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We investigated two hypotheses: (1) that oral inoculation of Il10-/- mice would result in greater and more consistent intestinal inflammation than that observed in Il10-/- mice not receiving this inoculation, and (2) that this inflammation would be associated with changes in colon gene expression levels similar to those previously observed in human studies, and these mice would therefore be an appropriate model for human CD.
|
20630110 |
2010 |