|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interleukin-10 knockout (IL-10 KO) mouse is a well-established murine model of IBD which develops spontaneous intestinal inflammation that resembles Crohn's disease.
|
25544730 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The successful Phase I clinical trial with a L. lactis strain secreting interleukin-10 for Crohn's disease has opened new horizons for the use of genetically engineered LAB as delivery vehicles.
|
19202351 |
2009 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Interleukin 10 knockout (IL-10-/-) mice spontaneously develop a Th1 T cell mediated colitis with many similarities to Crohn's disease.
|
12584217 |
2003 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
IL-10 knockout (IL-10 KO) mice were used as the human CD models in this study.
|
31677991 |
2020 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
To examine whether IL-10-CD associations extended to paediatric-onset CD.
|
19210299 |
2009 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohns disease.
|
31158947 |
2020 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We compared effector and regulatory T-cell-related markers such as interleukin (IL)-17, interferon (IFN)-gamma, IL-4, and Foxp3 transforming growth factor (TGF)-beta CTLA-4 and markers for innate immune activation such as IL-6, IL-10, IL-18, IL-23, tumor necrosis factor (TNF)-alpha, and IL-12p70, studied with immunohistochemistry and RT-PCR in ileal biopsies from patients with active or inactive CD and from control subjects.
|
18512248 |
2008 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
|
26974007 |
2016 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Both CD and UC samples exhibited gene and protein expression of HLA-G; and the HLA-G5 expression is differentially correlated with TNF and IL-10 levels depending on the type of the underlying inflammatory bowel disorder.
|
29588183 |
2018 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The presence of a family history of IBD and the clinical course of Crohn disease differed between patients with mutations in the IL-10 pathway and those without such mutations.
|
25373860 |
2015 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We quantified the transcriptional expression of IL-23, IL-12, IL-17A, IL-17F, IL-6, and IL-10 in healthy, noninflammatory duodenum, ileum, and colon and in inflamed and noninflamed biopsies of pediatric patients with Crohn's disease (CD) and ulcerative colitis (UC).
|
21994045 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
One of the most common murine models for studying CD is IL-10-/- mouse.
|
31509557 |
2019 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-10 polymorphisms in Spanish patients with IBD.
|
16043989 |
2005 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apoptosis resistance of mucosal lymphocytes and IL-10 deficiency in patients with steroid-refractory Crohn's disease.
|
21674705 |
2011 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
These data provide evidence that the effect of TNF alpha, LT alpha and IL-10 gene polymorphisms on cytokine production differ in CD, UC patients and controls.
|
11196710 |
2000 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We reproduced the association of the interleukin 10 locus with CD (P = .007), although none of the significantly associated variants modified the coding sequence of interleukin 10.
|
29501442 |
2018 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
CTD_human |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
|
21102463 |
2010 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, the levels of IgG x TNF, IgA x IL-10 and IgG x IL-10 were also correlated in CD, indicating that ASCA production may be influenced by the inflammatory response.
|
30884988 |
2019 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Overall, the frequency for carriers of shorter GTn repeats in intron 2 of the TLR2 gene, which have previously been associated with low TLR2 expression and high IL-10 production, was slightly elevated in Crohn's disease and ulcerative colitis compared to healthy controls (16.0% resp.16.7% vs. 12.8%).
|
28388655 |
2017 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The IL-10 gene does not appear to contribute to the risk of developing UC or Crohn's disease.
|
9697979 |
1998 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two patients with Crohn's disease were heterozygous for the interleukin-10 Gly15Arg mutation.No homozygotes were found.
|
15843082 |
2005 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, innate cytokine production of TNF-α, IL-1β, IL-6 and IL-10 was not related to historical disease characteristics or disease severity in patients with quiescent CD.
|
26208333 |
2015 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Specific examples of the associations of genetic variation and symptoms, syndromes, and intermediate phenotypes, including neurotransmitter (serotonergic, α(2)-adrenergic, and cannabinoid) mechanisms, inflammatory pathways (IL-10, TNFα, GNβ3, and susceptibility loci involved in Crohn's disease), and bile acid metabolism, are explored.
|
22403795 |
2012 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Study of IL-10 production by isolated cell subsets showed that DCs, but not CD4(+) T cells, from penetrating Crohn's disease produced significantly less IL-10 in response to LPS.
|
19237638 |
2009 |