Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL6 had the most sensitivity and IL10 had the most specificity for diagnosis of sepsis.
|
29239828 |
2018 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Stimulation with S. epidermidis sepsis strains induced higher IL-6 and IL-10 expression than stimulation with colonization strains.
|
30146415 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis.
|
28052995 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, SCFA butyrate significantly attenuated the inflammation against sepsis through upregulation of anti-inflammatory IL-10.
|
27943364 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of 24 h delayed normobaric oxygen (NBO<sub>2</sub>) and HBO<sub>2</sub> treatment on the endogenous production of the inflammatory markers interleukin (IL)-6, tumor necrosis factor (TNF)-α and IL-10, and on mortality in rats with cecal ligation and puncture (CLP) induced sepsis.
|
29204105 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we identified a novel intracellular signaling molecule, cAMP-response element binding protein (CREB), which serves as a pivotal transcription factor for upregulating IL-10 production by B-1a cells in sepsis through its nuclear translocation and binding to putative responsive elements on IL-10 promoter.
|
28630091 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, the production of IL-10 in Th2 cells was higher in the patients with sepsis.
|
28375710 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that monocyte derived IL-10 acts to inhibit potentially protective cell mediated immune responses against B. pseudomallei, but may also moderate the pathological effects of excessive cytokine production during sepsis.
|
28216665 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
CD19<sup>+</sup>CD11b<sup>+</sup>CD5<sup>+</sup> B1a regulatory cells were shown to rapidly express IL-10 in a TLR2-dependent manner in response to <i>S. aureus</i>, and adoptive transfer of B1a cells was protective during acute systemic infection in IL-10-deficient hosts.
|
28167629 |
2017 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion</b> We uncovered an association between IL-10 1082 gene variation and sepsis in VLBW infants but did not identify associations between neonatal sepsis and TNF-α 308 or IL-6 gene variation.
|
27960200 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-8, IL-6, IL-10, and procalcitonin are useful as early biomarkers of sepsis.
|
28769538 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed inflammatory (im)balance by measuring pro-inflammatory interleukin-6 and anti-inflammatory interleukin-10 during three distinct time periods after sepsis, and assessed its association with mortality.
|
28257334 |
2017 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The variants of IL-10 -1082 A allele and IL-6 -174 C allele contributed to an increased risk of pneumonia-induced sepsis.
|
27388228 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytokine levels were higher in patients with sepsis vs. controls (interleukin [IL]-10, blisters: 65.9 vs. 4.3 pg/ml, P < 0.001, serum: 25.7 vs. 4.5 pg/ml, P = 0.004; IL-6, blisters: 41.9 vs. 0.03 pg/ml, P < 0.001, serum: 45.5 vs. 2.1 pg/ml, P < 0.001).
|
27514616 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We detected higher serum levels of cytokines TNF-α (5.7 vs. 0.7 pg/ml, P < 0.001), IL-6 (24.8 vs. 3.8 pg/ml, P < 0.001), IL-10 (30.0 vs. 11.9 pg/ml, P = 0.040), and VEGF (177.9 vs. 48.1 pg/ml, P = 0.018) in sepsis sera.
|
28086962 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
After adjustment for shock and sepsis status at admission, CD74 and IL10 levels were found to be significantly associated with IAI occurrence [subdistribution hazard ratio (95% confidence interval) 0.67 (0.46-0.97) for CD74 D3/D1 expression ratio and 2.21 (1.63-3.00) for IL10 at D3].
|
28477143 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This suggests that interleukins such as IL-6 and IL-10 have a close association with coagulopathy and fibrinolytic dysregulation in sepsis and can be considered as candidates for potential therapeutic targets in SAC.
|
27449508 |
2017 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively.
|
27592234 |
2016 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, the Th1, Th2, Treg transcription factors, and related cytokines IFN-γ, IL-4, and IL-10 levels of sepsis and severe sepsis patients in peripheral blood were significantly higher than those of the normal controls.
|
25403265 |
2015 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This work attempts to further quantitatively assess the association of three widely evaluated polymorphisms of IL-10 (-592C/A, -819C/T, -1082A/G) with sepsis susceptibility through a meta-analysis.
|
25497741 |
2015 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Patients with IL-10 (-1082A/A) genotypes were found significantly higher in post traumatic sepsis patients and had a significantly higher risk to developed sepsis complication (p < 0.05, OR = 0.86, C.I = 0.08-8.8).In case of TNF-α (-308) position, GA and GG genotype patients have a significantly lower risk of poor outcome (p < 0.05, OR = 0.25, C.I = 0.01-1.3) and (p < 0.05, OR = 0.22, C.I = 0.01-0.5) in comparison to AA genotype.
|
26561011 |
2015 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-10R by Ab or genetic deficiency of IL-10 resulted in 3-5-fold higher concentrations of IL-27(p28) in endotoxic shock and polymicrobial sepsis.
|
25348624 |
2014 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In response to pathogen infection, pro-inflammatory cytokines [interleukin-6 (IL-6), IL-8, IL-18 and tumor necrosis factor-α (TNF-α)] and anti-inflammatory cytokine (IL-10) increased in patients with sepsis.
|
24292568 |
2014 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the increased ILT4 expression and IL-10 production and the decreased CD86 expression and IL-12 production indicate that during sepsis monocytes undergo substantial modulation of the surface and cytokine phenotype.
|
23911358 |
2013 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This study confirms that an active response against pediatric sepsis involves the expression of HMOX1 and IL10, suggesting that the high antioxidant status associated with HMOX1 short-allele septic carriers might provide a beneficial environment for sepsis resolution.
|
24201221 |
2013 |