|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location.
|
19673019 |
2009 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we demonstrate that the 3020insC frameshift-mutation in the NOD2 gene associated with Crohn's disease results in defective release of IL-10 from blood mononuclear cells after stimulation with the Toll-like receptor (TLR)2 ligands, peptidoglycan and Pam3Cys-KKKK, but not with bacterial LPS, a TLR4 ligand.
|
15214053 |
2004 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, clinical trials with IL-10 in Crohn's disease were disappointing, although some patients showed healing of intestinal mucosa.
|
12759436 |
2003 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in interleukin-10 gene according to mutations of NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn's disease.
|
16489646 |
2006 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, in CD, circRNA_103516 correlated positively with CDAI (<i>P</i> < 0.001), CRP (<i>P</i> < 0.001), ESR (<i>P</i> < 0.001), TNF-α (<i>P</i> < 0.001), and IFN-γ (<i>P</i> < 0.001) and negatively correlated with IL-10 (<i>P</i> = 0.006).
|
31749597 |
2019 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Preliminary results have shown that antisense oligonucleotides (anti-ICAM), anti-cytokine antibodies (anti-TNF) or recombinant human cytokines (IL-10 or IL-11) are effective in some patients with Crohn's disease refractory to steroids.
|
10210767 |
1999 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The immunopathology observed in IL-10(-/-) mice resembles that seen in Crohn's disease.
|
17631136 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
PEPT1 expression was characterized in mouse models of Crohn's disease-like ileitis (Tnf) or colitis (Il-10, Il-10XTlr2) and endoscopic tissue samples from descending colon of patients with IBD (n = 11) and controls (n = 17).
|
24583477 |
2014 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Individuals heterozygous at IL10-1082 have significantly increased occurrence of IBD, both ulcerative colitis and Crohn's disease (P<0.01).
|
20518842 |
2010 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
The successful Phase I clinical trial with IL-10-producing Lactococcus lactis for Crohn's disease has opened new avenues for the use of transgenic bacteria as delivery vehicles.
|
17184157 |
2007 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study was aimed at figuring out whether DHA could ameliorate the Crohn's colitis by activating GPR120 and whether GPR120 could be a potential therapeutic target for CD.16 week-old mice included in our present study were divided into three groups, WT group, IL-10 KO group and DHA group(IL-10 KO mice with DHA treatment, i.g., 35.5mg/kg/d), containing 8 mice in each group.
|
28039475 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The rs3024505 marker polymorphism flanking the IL-10 gene was significantly associated with risk of UC and CD, whereas no association was found between IL-1 beta or HO-1 gene polymorphisms and risk of CD and UC in this Danish study, suggesting that IL-10, but not IL-1 beta or HO-1, has a role in IBD etiology in this population.
|
20509889 |
2010 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
miR-155 Regulates IL-10-Producing CD24<sup>hi</sup>CD27<sup>+</sup> B Cells and Impairs Their Function in Patients with Crohn's Disease.
|
28824639 |
2017 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Serum concentrations of IL-4 and IL-10 were measured using an ELISA technique, and intestinal IL-4 and IL-10 mRNA was detected by a reverse transcriptase polymerase chain reaction (RT-PCR) in 34 patients with inflammatory bowel disease (IBD) (20 with UC and 14 with CD) and compared to 12 control subjects.
|
8794795 |
1996 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
DNA was extracted from blood cells of patients with Crohn's disease (CD) or with ulcerative colitis (UC) for IL-10 genotyping.
|
10551422 |
1999 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
We identified a possible association of both IL10 SNPs and TNFalpha-857 with CD.
|
15937090 |
2005 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
Interestingly, we also found that B cells presented an inhibitory effect in CD bacteria-mediated skewing toward Th1/Th17 cells and promoted IL-10 secretion in CD bacteria-stimulated PBMCs.
|
29031634 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Screening of the coding region of the IL-10 gene by polymerase chain reaction--single strand conformation polymorphism (PCR-SSCP) analysis revealed a rare sequence variation in exon 1 leading to an amino acid exchange (G-->A; G15R) in two patients with CD and five healthy controls.
|
11271474 |
2000 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002).
|
30665494 |
2019 |
|
Crohn Disease
|
0.700 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome was upregulated in colonic mucosa of both IL-10-/- mice and Crohn's patients.
|
27993998 |
2017 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We confirmed impairment in phosphorylation of hnRNP-A1 and binding of hnRNP-A1 to the IL10 locus in peripheral blood mononuclear cells from patients with Crohn's disease who bear the 3020insC mutation and have lower production of IL-10.
|
19349988 |
2009 |
|
Crohn Disease
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to characterize IL-10R expression and IL-10R-mediated suppression in patients with CD.
|
29045353 |
2018 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated whether genetic variants of the IL-10 gene were associated with CD in a New Zealand population.
|
21354456 |
2011 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The role of functional polymorphisms at positions -627 and -1117 in the IL-10 gene as candidate susceptibility loci in inflammatory bowel disease and their importance in determining disease extent were evaluated in 159 patients with ulcerative colitis (83 left-sided; 76 extensive), 90 patients with Crohn's disease (22 small bowel; 29 large bowel; 39 both), and 227 controls.
|
11478505 |
2001 |
|
Crohn Disease
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-10 receptor mutations in children with neonatal-onset Crohn's disease and intractable ulcerating enterocolitis.
|
23839161 |
2013 |