|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
According to the results of this study, the presence of AA genotype in both CCR5 and IRS1 is associated with type 2 diabetes.
|
30884193 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The PPARG Pro12 is associated with insulin resistance and this polymorphism interacts with IRS1 Gly972Arg, to increase the risk of T2DM in the mixed-ancestry population of South Africa.
|
24447396 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thus, IRS-1 polymorphisms may contribute in part to the insulin resistance and development of NIDDM in Japanese subjects; however, they do not account for the major part of the decrease in insulin-stimulated glucose uptake which is observed in subjects with clinically apparent NIDDM.
|
8739921 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The most common IRS1 variant, a Gly --> Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations.
|
15222685 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Two mutations of the IRS-1 gene (Gly(972)Arg and Ala(513)Pro) have been described, although their roles in the development of insulin resistance and non-insulin-dependent diabetes mellitus (NIDDM) remain controversial.
|
9162610 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (-866G>A), and IRS1 (G972R) genes were studied for their ability to predict T2D in 2,293 individuals participating in the Botnia study in Finland.
|
17570749 |
2005 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The STRP alleles in IRS-1 were significantly different between NIDDM and control subjects (p = 0.015).
|
8960833 |
1996 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Interaction of the G protein beta 3 subunit T825 allele and the IRS-1 Arg972 variant in type 2 diabetes.
|
11121369 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Thus, our data suggest that the common T2D susceptibility polymorphism of TCF7L2 (rs7903146 C/T) gene, and the G972R polymorphism of the IRS1 gene, seem to predispose to GDM in Greek women.
|
20540670 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The Gly972Arg mutation in the IRS-1 gene has been found to be associated with insulin resistance and type II diabetes.
|
12588284 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The mutation of the IRS-1 gene is one of the genetic risk factors which, it is speculated, is associated with insulin resistance or predisposition to type 2 diabetes.
|
18615395 |
2008 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that IRS1 locus may be common locus for type 2 diabetes across different ethnicities.
|
22046406 |
2011 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Unlike previously reported T2D risk loci, which predominantly associate with impaired beta cell function, the C allele of rs2943641 was associated with insulin resistance and hyperinsulinemia in 14,358 French, Danish and Finnish participants from population-based cohorts; this allele was also associated with reduced basal levels of IRS1 protein and decreased insulin induction of IRS1-associated phosphatidylinositol-3-OH kinase activity in human skeletal muscle biopsies.
|
19734900 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants.
|
19557384 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
To replicating the associations of type 2 diabetes (T2D) and six novel reported variants in Han Chinese lean individuals of first episode T2D, a total of six high risk single nucleotide polymorphisms (SNPs) from the BCL11A, DUSP9, IRS1, CENTD2, ADRA2A, and CDKAL1 genes were examined.
|
21643948 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Carriers of the PPARγ variant allele had statistically significantly lower rates of type 2 diabetes (P = 0.04), lower BMI (P = 0.01), and HOMA scores [P = 0.004; non-Hispanic White (NHWs) only]; carriers of the TNF-α variant A allele had higher serum glucose (P = 0.004, NHW only); and the IRS-1 variant was associated with higher leptin levels (P = 0.003, Hispanics only).
|
29256014 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The insulin receptor substrate-1 (IRS1) gene is considered a major T2DM gene, and common genetic variations near the IRS1 gene were found to be associated with T2DM, insulin resistance, adiposity, and CAD.
|
22797928 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
These results suggest that the Arg(972) IRS-1 variant could contribute to the risk for atherosclerotic cardiovascular diseases associated with type 2 diabetes by producing a cluster of insulin resistance-related metabolic abnormalities.
|
12843189 |
2003 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Despite genotyping 9,000 people and >95% power to reproduce the estimated OR from the recent meta-analysis, we were unable to replicate the association of the IRS-1 G972R polymorphism with type 2 diabetes.
|
15561965 |
2004 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Two IRS1 variants (rs7578326 and rs2943641) identified by genome-wide association studies as related to type 2 diabetes were tested for their associations with IR and related traits and interaction with diet in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 820) and the Boston Puerto Rican Health Study (BPRHS) (n = 844).
|
23596181 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Diverse single nucleotide polymorphisms (SNPs) of the IRS1 gene have been associated with insulin resistance and T2D risk.
|
19716569 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The mutation of insulin receptor substrate-1 gene in Chinese patients with non-insulin-dependent diabetes mellitus.
|
11775217 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, Western blot analysis revealed that T2DM rats had enhanced nuclear translocation of NF-κB as well as elevated phosphorylation of Ser307 in IRS-1(insulin receptor substrate 1).
|
28651236 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Moreover, cerebrocortical insulin resistance is found in individuals with the Gly972Arg polymorphism in IRS-1, which is considered a type 2 diabetes risk gene.
|
16877540 |
2006 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the insulin receptor substrate 1 (IRS1) gene, Glu23Lys in the potassium inwardly-rectifying channel gene (KCNJ11), and Pro12Ala in the peroxisome proliferative-activated receptor gamma2 gene (PPARG2).
|
14988278 |
2004 |