IRS1, insulin receptor substrate 1, 3667

N. diseases: 233; N. variants: 15
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 Biomarker disease HPO
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 CausalMutation disease CLINVAR
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.400 Biomarker phenotype HPO
CUI: C1840169
Disease: CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO
CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation disease CLINVAR
CUI: C1852091
Disease: INSULIN RESISTANCE, SUSCEPTIBILITY TO
INSULIN RESISTANCE, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation disease CLINVAR
CUI: C4703555
Disease: Decreased waist to hip ratio
Decreased waist to hip ratio 		0.100 Biomarker phenotype HPO
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.100 GeneticVariation disease LHGDN Polycystic ovary syndrome patient and healthy control genotypes, with the CYP21 and IRS1 variants. 15705377 2005
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.400 Biomarker disease BEFREE Insulin increased insulin receptor substrate 1 (IRS-1) tyrosine phosphorylation, IRS-1-associated phosphatidylinositol (PI) 3-kinase activity, and phosphorylation of Akt Ser473 and AS160, a newly described Akt substrate that plays a role in GLUT4 exocytosis, approximately 2.3 fold before treatment. 15855334 2005
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker disease CTD_human Obese mouse ovaries had decreased Irs1, Foxo3a, Cyp2e1, MiR-103, and MiR-21 but increased Kitlg, Akt1, and miR-184 levels relative to lean littermates. 23954404 2013
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.100 AlteredExpression disease BEFREE PCOS was associated with lower expression of GLUT4 and IRS1 and a higher level of oxidative stress in VAT, which was strongly correlated with WC and HOMA-IR. 25064406 2014
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon. 25477374 2015
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.100 PosttranslationalModification disease BEFREE Hyperglycemia (25 mM glucose) and TNF-alpha showed analogous (> 50% inhibition) effects on tyrosine phosphorylation of insulin receptor substrate-1, Shc, p60, and p44, whereas opposite effects were observed for tyrosine phosphorylation of FAK125, which is dephosphorylated after insulin stimulation. 8617880 1996
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.010 Biomarker disease BEFREE IRS-1 was significantly increased in cirrhosis compared to normal liver (1.61 +/- 0.31 vs 0.86 +/- 0.21; P < 0.05). 10210639 1999
CUI: C1623038
Disease: Cirrhosis
Cirrhosis 		0.010 Biomarker disease BEFREE IRS-1 was significantly increased in cirrhosis compared to normal liver (1.61 +/- 0.31 vs 0.86 +/- 0.21; P < 0.05). 10210639 1999
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE IRS-1 was expressed at high levels in estrogen-dependent growth of MCF-7 xenografts, but withdrawal of estrogen, which decreased tumor growth, resulted in a dramatic decrease in IRS-1 expression. 10319328 1999
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.030 AlteredExpression group BEFREE IRS-1 and IGF-IR were expressed at high levels in control tissues and in well and moderately differentiated carcinomas but at low levels in poorly differentiated breast cancers. 11102895 2000
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 Biomarker disease BEFREE Insulin receptor substrate-1 (IRS-1) is a key protein in the IGF signaling pathway in the estrogen-dependent MCF-7 breast carcinoma cell line. 12960057 2003
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.400 Biomarker group BEFREE Insulin receptor substrate-1 and -2 (IRS-1 and IRS-2), two major downstream molecules of IGF-1R, are known to be important in the genesis of diabetes. 14604996 2004
CUI: C0011847
Disease: Diabetes
Diabetes 		0.100 Biomarker disease BEFREE Insulin receptor substrate-1 and -2 (IRS-1 and IRS-2), two major downstream molecules of IGF-1R, are known to be important in the genesis of diabetes. 14604996 2004
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.100 GeneticVariation phenotype BEFREE IRS-1 G972R was associated with the baseline characteristics of the patients with GDM, and might be related to insulin resistance that is seen in obese patients with GDM. 16522427 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE IRS-1 and IRS-2 are expressed in normal mammary epithelial cells and in breast carcinoma cells, where they have been implicated in mediating signals to promote tumor cell survival, growth and motility. 17361103 2007
CUI: C4733092
Disease: estrogen receptor-negative breast cancer
estrogen receptor-negative breast cancer 		0.020 Biomarker disease BEFREE Insulin receptor substrate 1 knockdown in human MCF7 ER+ breast cancer cells by nuclease-resistant IRS1 siRNA conjugated to a disulfide-bridged D-peptide analogue of insulin-like growth factor 1. 17922544 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 AlteredExpression disease BEFREE IRS-1 may serve as an alternative target to overexpressed IGF1R in breast cancer. 17922544 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.100 AlteredExpression disease BEFREE IRS-1 may serve as an alternative target to overexpressed IGF1R in breast cancer. 17922544 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.900 GeneticVariation disease BEFREE IRS1 G972R polymorphism and type 2 diabetes: a paradigm for the difficult ascertainment of the contribution to disease susceptibility of 'low-frequency-low-risk' variants. 19557384 2009