|
Acute myocardial infarction
|
0.030 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNAs H19, MALAT1 and MIAT as potential novel biomarkers for diagnosis of acute myocardial infarction.
|
31302423 |
2019 |
|
Acute myocardial infarction
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the plasma levels of MIAT were significantly increased in patients with AMI compared with non‑AMI patients.
|
31661125 |
2019 |
|
Acute myocardial infarction
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The expression of a novel lncRNA, myocardial infarction associated transcript 1(Mirt1), has been shown to be upregulated in acute myocardial infarction (AMI).
|
28668956 |
2017 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among the modules, MEG3 and MIAT may play important roles in the development of LUAD by interactions with miR-106 which then regulated the MAPK9 to involve in MAPK signaling pathways.
|
27338053 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.
|
30836187 |
2019 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
MIAT knockdown attenuated atherosclerosis progression, reduced necrotic core size, and increased plaque stability in vivo.
|
30755588 |
2019 |
|
Arteriosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that upregulation of MIAT can aggravate AS injury in AS mice via the activation of the PI3K/Akt signaling pathway, which could provide a novel target for the treatment of AS.
|
31237148 |
2019 |
|
Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
MIAT facilitated cell proliferation, accelerated cell cycle progression and inhibited apoptosis in ox-LDL-induced AS cell lines, while this effect was partly reversed by miR-181b overexpression.
|
29136944 |
2018 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
MIAT knockdown attenuated atherosclerosis progression, reduced necrotic core size, and increased plaque stability in vivo.
|
30755588 |
2019 |
|
Atherosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
MIAT facilitated cell proliferation, accelerated cell cycle progression and inhibited apoptosis in ox-LDL-induced AS cell lines, while this effect was partly reversed by miR-181b overexpression.
|
29136944 |
2018 |
|
Atherosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our study suggests that upregulation of MIAT can aggravate AS injury in AS mice via the activation of the PI3K/Akt signaling pathway, which could provide a novel target for the treatment of AS.
|
31237148 |
2019 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Reduced levels of MIAT augmented the apoptotic response of breast cancer cells to a wide range of apoptotic stimuli.
|
29914974 |
2018 |
|
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Knockdown MIAT suppressed breast cancer cell proliferation and caused G1 arrest in cell cycle.
|
29345338 |
2018 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that MIAT acted as a competing endogenous RNA (ceRNA) to regulate the expression of dual specificity phosphatase 7 (DUSP7) by taking up miR-155-5p in breast cancer.
|
29100300 |
2017 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
In the present study, we aimed to explore the role of the lncRNA myocardial infarction-associated transcript (MIAT) in epithelial ovarian cancer tumorigenesis.
|
30393480 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
However, the functional relevance of MIAT in ER-positive breast cancer tumorigenesis was poorly understood.
|
29792859 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Taken together with the recent demonstration of oncogene characteristics, our observations suggest that MIAT plays an important role in breast tumorigenesis.
|
29914974 |
2018 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Tumor xenograft models were created to detect the role of MIAT in vivo tumorigenesis.
|
31404776 |
2019 |
|
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings demonstrated that knockdown of MIAT by siRNA enhances lung cancer cells to gefitinib through the PI3K/Akt signaling pathway by epigenetically regulating miR-34a.
|
29487526 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Furthermore, the Luciferase reporter gene assay and RIP assay showed that miR-613 was a direct target of MIAT in DLX6-AS1 in OC tissues.
|
31378881 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We thus infer that differential expression of MIAT and SNORD114-10 could play an important role during OC metastasis.
|
29387224 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
Biomarker
|
disease |
BEFREE |
Moreover, we revealed that MIAT might function as an endogenous miR-330-5p sponge to regulate the target gene of miR-330-5p in epithelial ovarian cancer progression.
|
30393480 |
2018 |
|
Carcinoma, Ovarian Epithelial
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Here we report an integrated analysis of >700 ovarian cancer molecular profiles, including genomic data sets, from four patient cohorts identifying lncRNA DNM3OS, MEG3, and MIAT overexpression and their reproducible gene regulation in ovarian cancer EMT.
|
29150601 |
2017 |
|
cardiac event
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Association of long non-coding RNA MIAT and MALAT1 expression profiles in peripheral blood of coronary artery disease patients with previous cardiac events.
|
31188931 |
2019 |
|
Cardiac fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings also promise that normalization of MIAT level may prove to be a therapeutic option for the treatment of MI-induced cardiac fibrosis and the associated cardiac dysfunction.
|
28198439 |
2017 |