|
Cerebral Infarction
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our study showed that MIAT promoted HMGB1 expression by competitively binding to miR-204-5p to regulate the injury of CMECs after cerebral ischemia.
|
31628679 |
2020 |
|
Corneal Neovascularization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of MIAT and Ang II was increased, while miR-1246 was decreased in CRNV rat model.
|
30782069 |
2020 |
|
Middle Cerebral Artery Occlusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of MIAT promoted angiogenesis, promoted miR-204-5p expression and inhibited HMGB1 expression in brain tissue of MCAO rats.
|
31628679 |
2020 |
|
Cerebral Palsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In our previous RNA-seq study, we found that lncRNA myocardial infarction-associated transcript (MIAT) was differentially expressed in pancreatic tissues of chronic pancreatitis (CP) patients.
|
30582203 |
2019 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The siRNA against lncRNA-MIAT, miR-328a-5p mimic and overexpression vector of LPL were transfected to investigate the specific effects of miR-328a-5p, lncRNA-MIAT and LPL on ED in diabetes.
|
30660685 |
2019 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.
|
30836187 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Consistently, MIAT knockdown slows AML progression in immunodeficient mice.
|
31698307 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, our results demonstrate that MIAT is involved in promoting the progression of AML, at least partly, through negative regulation of miR-495, and therefore provide a promising target for treatment of AML.
|
31698307 |
2019 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Western blotting was performed to explore the molecular mechanisms of MIAT in melanoma.
|
30614798 |
2019 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The migrated and invaded ability of the Wilms' tumor cells was inhibited due to the loss of MIAT.
|
31841180 |
2019 |
|
Nervous System Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Myocardial Infarction Associated Transcript (MIAT) is a subnuclear lncRNA that interferes with alternative splicing and is associated with increased risk of various heart conditions and nervous system tumours.
|
30836187 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study attempted to see the role of MIAT in a cell model of osteoarthritis (OA).
|
31204523 |
2019 |
|
Pancreatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the function of MIAT in CP remains unknown.
|
30582203 |
2019 |
|
Harlequin Fetus
|
0.010 |
Biomarker
|
disease |
BEFREE |
In vivo experiment proved MIAT promoted motor function and relieved HI injury.
|
30563429 |
2019 |
|
Fibrosis of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was aimed to investigate the function and underlying mechanism of MIAT in pancreatic fibrosis.
|
30582203 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.
|
30836187 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.
|
30836187 |
2019 |
|
Squamous cell carcinoma of tongue
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis showed that there was no significant difference between MIAT in TSCC specimen and serum to differentiate death and non-death of TSCC patients.
|
31166624 |
2019 |
|
cardiac event
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Association of long non-coding RNA MIAT and MALAT1 expression profiles in peripheral blood of coronary artery disease patients with previous cardiac events.
|
31188931 |
2019 |
|
Cardiomyopathies
|
0.010 |
AlteredExpression
|
group |
BEFREE |
After inhibiting the expression of MIRT1, the activation of NF-κB signaling pathway was inhibited, the damage of cardiac function and cardiomyopathy was alleviated, the area of myocardial fibrosis was decreased, the degree of myocardial apoptosis was decreased, the degree of oxidative stress and inflammatory injury was obviously improved.
|
30611788 |
2019 |
|
Childhood Kidney Wilms Tumor
|
0.010 |
Biomarker
|
disease |
BEFREE |
The migrated and invaded ability of the Wilms' tumor cells was inhibited due to the loss of MIAT.
|
31841180 |
2019 |
|
Sjogren's Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
It is still unclear whether myocardial infarction associated transcript 2 (Mirt2)-miR-377 mediates the inflammatory pathogenesis in Sjögren's syndrome (SS).
|
31198060 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together with the recent demonstration of the involvement of MIAT in glioblastoma, our observations suggest that MIAT could possess tumour-promoting properties, thereby acting as an oncogene, and has the potential to be used as a reliable biomarker for neuroblastoma and glioblastoma and be employed for prognostic, predictive and, potentially, therapeutic purposes for these cancers.
|
30836187 |
2019 |
|
Progression of non-small cell lung cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the exact role of lncRNA MIAT in the progression of non-small cell lung cancer (NSCLC) and to explore the possible underlying mechanism.
|
31298331 |
2019 |
|
Cleft palate, isolated
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In our previous RNA-seq study, we found that lncRNA myocardial infarction-associated transcript (MIAT) was differentially expressed in pancreatic tissues of chronic pancreatitis (CP) patients.
|
30582203 |
2019 |