|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study did not show a strong involvement of ecNOS4 gene polymorphism, at least in the basal NO production in patients with essential hypertension, however, it indicated that ecNOS4 gene polymorphism might modulate changes in BP due to water load in patients on hemodialysis, thus indicating that these polymorphisms may be involved in the pathophysiology of volume-dependent hypertension.
|
10867538 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests a strong association of G894 T eNOS polymorphism with susceptibility to EH in Morocco.
|
30053839 |
2018 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients.
|
29132319 |
2017 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls.
|
18325347 |
2008 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with coronary artery disease, but their linkage with primary hypertension is controversial.
|
17024134 |
2006 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the NOS3 tagSNPs rs3918226, rs3918188, and rs743506, and their haplotypes, affect the antihypertensive responses to enalapril in 101 patients with essential hypertension.
|
27060232 |
2016 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The four-repeat allele of the ecNOS gene was thus associated with EH and may be a genetic marker of this disease in Japanese subjects.
|
9504461 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that eNOS4 gene polymorphisms are unlikely to be the major genetic susceptibility factors for essential hypertension in the Xinjiang Kazakh population.
|
17492127 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The higher prevalence of endothelial nitric oxide synthase 298G allele among hypertensives suggests that this gene is involved in essential hypertension but this observation needs further confirmation.
|
9533414 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to investigate the association of eNOS gene polymorphism with essential hypertension in a south Indian population.
|
18582449 |
2008 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
|
16765468 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension.
|
12923396 |
2003 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension.
|
24292621 |
2014 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the possible association between the alleles of simple tandem repeat DNA polymorphism of the endothelial constitutive NOS (cNOS) gene and EH in Japanese subjects.
|
9084930 |
1997 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT).Findings, however are not uniform.
|
17935708 |
2008 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
|
18164968 |
2008 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to assess the potential impact of obesity, and angiotensin-converting enzyme (ACE) I/D polymorphism and endothelial nitric oxide synthase gene (NOS3) 4a/4b, G894T and -T786C variants on the essential hypertension.
|
26579574 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the genetic involvement of the eNOS gene in essential hypertension, we examined the possible association between essential hypertension and several polymorphisms including the Glu298Asp variant, variable number tandem repeats in intron 4 (eNOS4b/4a), and two polymorphisms in introns 18 and 23.
|
9674630 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Abstract Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population.
|
24846690 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese.
|
20882485 |
2010 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results do not support the previous observation that the molecular variant of the eNOS gene may confer principal susceptibility for essential hypertension but rather suggest the existence of sampling variation.
|
10205226 |
1999 |
|
Essential Hypertension
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating <i>HSD3B2</i> and <i>ACE</i> methylation.
|
29752343 |
2018 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities.
|
26227630 |
2015 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
A role for NOS3 in onset of essential hypertension (HT) is, however, controversial.
|
10981549 |
2000 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine whether the endothelial nitric oxide synthase gene is involved in human essential hypertension, we identified informative biallelic and multiallelic markers of this locus and performed case-control and linkage studies in hypertensive subjects and normotensive control subjects.
|
7528648 |
1995 |