|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine whether the endothelial nitric oxide synthase gene is involved in human essential hypertension, we identified informative biallelic and multiallelic markers of this locus and performed case-control and linkage studies in hypertensive subjects and normotensive control subjects.
|
7528648 |
1995 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Hypertension in mice lacking the gene for endothelial nitric oxide synthase.
|
7545787 |
1995 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.
|
8667023 |
1996 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the possible association between the alleles of simple tandem repeat DNA polymorphism of the endothelial constitutive NOS (cNOS) gene and EH in Japanese subjects.
|
9084930 |
1997 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene.
|
9201025 |
1997 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Coronary hemodynamics in endothelial NO synthase knockout mice.
|
9468189 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The four-repeat allele of the ecNOS gene was thus associated with EH and may be a genetic marker of this disease in Japanese subjects.
|
9504461 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The higher prevalence of endothelial nitric oxide synthase 298G allele among hypertensives suggests that this gene is involved in essential hypertension but this observation needs further confirmation.
|
9533414 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the genetic involvement of the eNOS gene in essential hypertension, we examined the possible association between essential hypertension and several polymorphisms including the Glu298Asp variant, variable number tandem repeats in intron 4 (eNOS4b/4a), and two polymorphisms in introns 18 and 23.
|
9674630 |
1998 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.
|
9692709 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results do not support the previous observation that the molecular variant of the eNOS gene may confer principal susceptibility for essential hypertension but rather suggest the existence of sampling variation.
|
10205226 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.
|
10362674 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation.
|
10484454 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-).
|
10549894 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Infarct size and nitric oxide synthase in murine myocardium.
|
10652188 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study did not show a strong involvement of ecNOS4 gene polymorphism, at least in the basal NO production in patients with essential hypertension, however, it indicated that ecNOS4 gene polymorphism might modulate changes in BP due to water load in patients on hemodialysis, thus indicating that these polymorphisms may be involved in the pathophysiology of volume-dependent hypertension.
|
10867538 |
2000 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.
|
10905473 |
2000 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
A role for NOS3 in onset of essential hypertension (HT) is, however, controversial.
|
10981549 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To further investigate the genetic involvement of the eNOS gene in essential hypertension, we examined the frequency of T-786-->C variant in two independent populations of persons with essential hypertension in Kyoto (n=215) and Kumamoto (n=186) and compared the frequency with that in each age- and gender-matched control (233 controls in Kyoto and 223 controls in Kumamoto).
|
11131266 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Searching for phenotypic expression of eNOS gene variants, we genotyped a group of patients with essential hypertension (H, n = 119) for the Glu298Asp polymorphism and compared them with age- and sex-matched healthy normals (N, n = 85).
|
11394896 |
2001 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
|
11457755 |
2001 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.
|
11904450 |
2002 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence for the involvement of eNOS single nucleotide polymorphisms in the development of essential hypertension is limited, though the eNOS Glu298Asp polymorphism appears to influence the blood pressure response to exercise.
|
12530931 |
2003 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings argue against an association between ecNOS polymorphism and preeclampsia and support the hypothesis for a different pathogenesis of GH in respect to EH.
|
12908999 |
2003 |