|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study did not show a strong involvement of ecNOS4 gene polymorphism, at least in the basal NO production in patients with essential hypertension, however, it indicated that ecNOS4 gene polymorphism might modulate changes in BP due to water load in patients on hemodialysis, thus indicating that these polymorphisms may be involved in the pathophysiology of volume-dependent hypertension.
|
10867538 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests a strong association of G894 T eNOS polymorphism with susceptibility to EH in Morocco.
|
30053839 |
2018 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation.
|
10484454 |
1999 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study aims to investigate the association between these three polymorphisms in the NOS3 gene and EH in Sudanese patients.
|
29132319 |
2017 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the role of the -922A/G, -786T/C, 4b/4a, and 894G/T polymorphisms of the NOS3 and NO(x) levels in 800 consecutive unrelated subjects comprising 455 patients of essential hypertension and 345 controls.
|
18325347 |
2008 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene.
|
9201025 |
1997 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Striatal malonate lesions are attenuated in neuronal nitric oxide synthase knockout mice.
|
8667023 |
1996 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase (eNOS) gene polymorphisms are associated with coronary artery disease, but their linkage with primary hypertension is controversial.
|
17024134 |
2006 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined whether the NOS3 tagSNPs rs3918226, rs3918188, and rs743506, and their haplotypes, affect the antihypertensive responses to enalapril in 101 patients with essential hypertension.
|
27060232 |
2016 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The four-repeat allele of the ecNOS gene was thus associated with EH and may be a genetic marker of this disease in Japanese subjects.
|
9504461 |
1998 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Ejaculatory abnormalities in mice lacking the gene for endothelial nitric oxide synthase (eNOS-/-).
|
10549894 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.
|
10362674 |
1999 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Akt-dependent phosphorylation of endothelial nitric-oxide synthase mediates penile erection.
|
11904450 |
2002 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase.
|
11457755 |
2001 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Premature death and age-related cardiac dysfunction in male eNOS-knockout mice.
|
15350840 |
2004 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo.
|
9692709 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The results suggest that eNOS4 gene polymorphisms are unlikely to be the major genetic susceptibility factors for essential hypertension in the Xinjiang Kazakh population.
|
17492127 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The higher prevalence of endothelial nitric oxide synthase 298G allele among hypertensives suggests that this gene is involved in essential hypertension but this observation needs further confirmation.
|
9533414 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to investigate the association of eNOS gene polymorphism with essential hypertension in a south Indian population.
|
18582449 |
2008 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance.
|
10905473 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the present study in a population of Pakistani adult Pathans does not support the association of the eNOS gene G894T polymorphism to essential hypertension.
|
16765468 |
2007 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/bgene polymorphisms are associated with essential hypertension.
|
12923396 |
2003 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that polymorphism of rs1800780 (A→G) in the eNOS gene may be one of the most important genetic factors associated with essential hypertension susceptibility, and those who have haplotype TGA may be at risk to develop essential hypertension.
|
24292621 |
2014 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigated the possible association between the alleles of simple tandem repeat DNA polymorphism of the endothelial constitutive NOS (cNOS) gene and EH in Japanese subjects.
|
9084930 |
1997 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several reports suggested association between the T allele of the endothelial nitric oxide synthase gene polymorphism (eNOS) Glu298Asp (G --> T at nucleotide 894, exon 7) with essential hypertension (EHT).Findings, however are not uniform.
|
17935708 |
2008 |