NPY, neuropeptide Y, 4852

N. diseases: 381; N. variants: 12
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE These various effects plus a number of others make NPY an attractive target for the potential treatment of human diseases, such as obesity, metabolic disorders, hypertension and heart failure. 12678499 2003
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE Reduced dopaminergic neurotransmission in the suprachiasmatic nucleus of seasonally obese animals appears to drive noradrenalin and NPY mediated transmissions in other nuclei to induce the obesity syndrome at the appropriate time of year. 14623356 2003
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE One of these, a cytosine to thymine (C-->T) substitution in the untranslated region between the genes for NPY Y1 and Y5 (allele frequency 0.11), was significantly associated with both lower fasting triglyceride level (152 vs 125 mg/dl), and higher high-density lipoprotein (HDL) concentrations (49 vs 45 mg/dl) (p < 0.01) in 306 obese subjects. 12220433 2002
CUI: C0028754
Disease: Obesity
Obesity 		0.300 AlteredExpression disease BEFREE To determine the possibility of the disturbance in neuropeptides in human obesity and their consequent changes in response to negative energy balance, we evaluated plasma and cerebrospinal fluid (CSF) leptin, NPY, and alpha-MSH levels in obese women before and after weight loss in comparison with normal control women. 11600552 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.300 AlteredExpression disease BEFREE Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding. 11334428 2001
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE The role of NPY in metabolic homeostasis: implications for obesity therapy. 11060746 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.300 GeneticVariation disease BEFREE Sequence variation within the neuropeptide Y gene and obesity in Mexican Americans. 10832764 2000
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE Significant linkage (P = 0.042) was found between obesity and NPY within the obese sibling pairs. 10207720 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE NPY deficiency attenuates the obesity syndrome of mice deficient for leptin (ob/ob), but these effects are not mediated by NPY signaling through the Y5R because Y5R-null ob/ob mice are equally obese. 9623983 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE Two complementary genetic approaches were used: 1) linkage analyses between obesity and polymorphic markers located nearby NPY and rNPY-Y1/-Y5 genes (respectively on chromosomes 7p15.1 and 4q[31.3-32]) in 93 French Caucasian morbidly obese families; 2) single strand conformation polymorphism (SSCP) scanning of the coding region of the NPY and rNPY-Y1 genes performed in 50 unrelated obese patients ascertained on the basis of a body mass index of 27 kg/m2 or more and a family history of obesity. 9222646 1997
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE Ultimately, characterization of the specific "feeding' receptors which mediate NPY's central effects on energy homeostasis may provide opportunities for designing drugs to manipulate and appetite and energy balance in man, notably obesity and the cachexia commonly associated with malignancy and chronic infection. 8871182 1996
CUI: C0028754
Disease: Obesity
Obesity 		0.300 Biomarker disease BEFREE The present study examined the neuropeptide-Y Y1 receptor gene (NPYY1R) for involvement in essential hypertension (HT) and obesity. 7902088 1993