|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01).
|
17895523 |
2007 |
|
Adenoma of large intestine
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study.
|
17895523 |
2007 |
|
Adenoma of large intestine
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have indicated that the small leucine-rich proteoglycan (SLR) osteoglycin (OGN) is downregulated in various cancers, including squamous cervical carcinoma, gastric cancer, and colorectal adenoma, indicating that OGN is a putative tumor suppressor.
|
31824171 |
2019 |
|
Adult Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
OGN-overexpressing meningioma cells demonstrated an elevated rate of cell proliferation, cell cycle activation, and colony formation as compared with cells transfected with control vector.
|
28923059 |
2017 |
|
Alcohol or Other Drugs use
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate the promise of a web-based, self-management intervention for difficult-to-engage OEF/OIF veterans with behavioral health and substance use concerns.
|
28270335 |
2017 |
|
Anorexia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice.
|
26870797 |
2015 |
|
Aortic Valve Stenosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
|
18443592 |
2008 |
|
Aortic Valve Stenosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, osteoglycin levels were higher in patients with less severe myocardial fibrosis and overall in the aortic stenosis patients osteoglycin levels negatively correlated with collagen content in the myocardium.
|
28958774 |
2018 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The proteomics analysis reveals proteins related to atherosclerosis formation including Mimecan, Ras Suppressor Protein-1 (RSUP-1) and Cathepsin D which identified as biomarker of cancerous tumors.
|
30616890 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of osteoglycin in atherosclerosis remains unclear.
|
29503411 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of osteoglycin in atherosclerosis remains unclear.
|
29503411 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The proteomics analysis reveals proteins related to atherosclerosis formation including Mimecan, Ras Suppressor Protein-1 (RSUP-1) and Cathepsin D which identified as biomarker of cancerous tumors.
|
30616890 |
2019 |
|
Back Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Results of fully adjusted logistic regression models revealed that OIF/OEF women in Puerto Rico had heightened risk for global pain-related disorders (i.e., any pain) (adjusted odds ratio [AOR], 1.45; 95% confidence interval [CI], 1.22-1.71), back pain (AOR, 1.83; 95% CI, 1.56-2.14), diabetes (AOR, 1.42; 95% CI, 1.03-1.95), hyperlipidemia (AOR, 3.34; 95% CI, 2.80-3.98), major depression (AOR, 1.78; 95% CI, 1.53-2.06), and bipolar depression (AOR, 1.66; 95% CI, 1.34-2.04).
|
31796346 |
2019 |
|
Brain Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
OGN mRNA expression was dramatically increased in meningiomas compared to a spectrum of other brain tumors and normal brain.
|
28923059 |
2017 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OGN expression was reduced in 24 paired BC samples compared with normal tissue.
|
31824171 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The effect of OGN on cell proliferation and tumorigenesis was examined in vitro and in vivo.
|
29499765 |
2018 |
|
Cardiac dilatation
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Adenoviral overexpression of osteoglycin in wild-type mice significantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI.
|
25520363 |
2015 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation.
|
28958774 |
2018 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, clinical studies link osteoglycin to insulin resistance and cardiovascular disease.
|
31396918 |
2019 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Osteoglycin (OGN) has been noted for its implication in cardiovascular disease in recent studies.
|
28069703 |
2017 |
|
Cervical Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A differential protein pattern for SCC was, e.g. over-expressed (OE) eukaryotic translation initiation factor 3-2β, neutrophil cytosolic factor 2, annexin A6 (ANXA6), for SVC it was OE cathepsin D, γ-catenin, RAB2A, for both cancers it was OE apolipoprotein E, tropomyosin 3, HSPA8, and underexpressed cytokeratin 13, osteoglycin.
|
21137014 |
2010 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Previous studies have indicated that the small leucine-rich proteoglycan (SLR) osteoglycin (OGN) is downregulated in various cancers, including squamous cervical carcinoma, gastric cancer, and colorectal adenoma, indicating that OGN is a putative tumor suppressor.
|
31824171 |
2019 |
|
Chronic Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our results indicate that serum osteoglycin is a potential predictor of adverse outcomes in patients with CKD.
|
28824047 |
2017 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hence, we aim to measure the OGN expression patterns and immune cells response in colorectal cancer(CRC).
|
30037719 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
This study clearly demonstrated that absence of mimecan and upregulation of TXNDC5 are involved in the early development of colorectal cancer.
|
17895523 |
2007 |