OGN, osteoglycin, 4969

N. diseases: 55; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 AlteredExpression group BEFREE Tumor OGN expression levels were positively associated with CD3, CD8, and PTPRC expressions in the training and testing sets from TCGA, respectively. 30037719 2018
CUI: C2350875
Disease: Constrictive Bronchiolitis
Constrictive Bronchiolitis 		0.010 Biomarker disease BEFREE Constrictive Bronchiolitis (CB) has been reported in US Operation Iraqi Freedom/Enduring Freedom (OIF/OEF) deployers but not in those from prior US conflicts. 30117179 2018
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.010 Biomarker disease BEFREE Mimecan and activinA, which have been shown to be upregulated in models of glaucoma, were both found to be elevated in POAG TM. 16565384 2006
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.010 AlteredExpression disease BEFREE Mimecan and activinA, which have been shown to be upregulated in models of glaucoma, were both found to be elevated in POAG TM. 16565384 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 Biomarker group BEFREE Osteoglycin (OGN) has been noted for its implication in cardiovascular disease in recent studies. 28069703 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.010 AlteredExpression group BEFREE OGN mRNA expression was dramatically increased in meningiomas compared to a spectrum of other brain tumors and normal brain. 28923059 2017
CUI: C0025286
Disease: Meningioma
Meningioma 		0.010 Biomarker disease BEFREE OGN-overexpressing meningioma cells demonstrated an elevated rate of cell proliferation, cell cycle activation, and colony formation as compared with cells transfected with control vector. 28923059 2017
CUI: C0278877
Disease: Adult Meningioma
Adult Meningioma 		0.010 Biomarker disease BEFREE OGN-overexpressing meningioma cells demonstrated an elevated rate of cell proliferation, cell cycle activation, and colony formation as compared with cells transfected with control vector. 28923059 2017
CUI: C1762616
Disease: Meningioma, benign, no ICD-O subtype
Meningioma, benign, no ICD-O subtype 		0.010 Biomarker disease BEFREE OGN-overexpressing meningioma cells demonstrated an elevated rate of cell proliferation, cell cycle activation, and colony formation as compared with cells transfected with control vector. 28923059 2017
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis 		0.010 Biomarker disease BEFREE Osteoglycin prevents the development of age-related diastolic dysfunction during pressure overload by reducing cardiac fibrosis and inflammation. 28958774 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.010 Biomarker disease BEFREE OGN may plays a significant role in osteoporosis, which may also provide a potential target for therapeutic intervention of senile osteoporosis characterized by altered differentiation of BMSCs into osteoblasts and adipocytes. 29073887 2017
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.030 Biomarker disease BEFREE OGN plays a restrictive role in colorectal cancer progression by reduced activation of EGFR/AKT/Zeb-1. 29499765 2018
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 Biomarker disease BEFREE OIF <343.4 pg/mL remained predictive of microalbuminuria (odds ratio = 11.60; 95% confidence interval: 1.25-107.47) after adjusting for confounding factors.Serum OIF is an independent diagnostic marker of DN. 30075597 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.010 AlteredExpression disease BEFREE OGN expression was reduced in 24 paired BC samples compared with normal tissue. 31824171 2019
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.010 AlteredExpression disease BEFREE OGN expression was reduced in 24 paired BC samples compared with normal tissue. 31824171 2019
CUI: C0279671
Disease: Cervical Squamous Cell Carcinoma
Cervical Squamous Cell Carcinoma 		0.010 AlteredExpression disease BEFREE A differential protein pattern for SCC was, e.g. over-expressed (OE) eukaryotic translation initiation factor 3-2β, neutrophil cytosolic factor 2, annexin A6 (ANXA6), for SVC it was OE cathepsin D, γ-catenin, RAB2A, for both cancers it was OE apolipoprotein E, tropomyosin 3, HSPA8, and underexpressed cytokeratin 13, osteoglycin. 21137014 2010
CUI: C0264732
Disease: Cardiac dilatation
Cardiac dilatation 		0.010 AlteredExpression disease BEFREE Adenoviral overexpression of osteoglycin in wild-type mice significantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI. 25520363 2015
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 AlteredExpression disease BEFREE Adenoviral overexpression of osteoglycin in wild-type mice significantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI. 25520363 2015
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group LHGDN All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.310 Biomarker phenotype BEFREE Altogether, our present data first time show that PFN1, NCL, CNDP2 and OGN are novel potential biomarkers for diagnosis and therapeutic targets for laryngeal carcinoma, and PFN1 is involved in the metastasis of laryngeal carcinoma. 24587265 2014
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 Biomarker disease BEFREE Another study reported that osteoglycin is a marker of low bone mineral density and vertebral fractures in women with type 2 diabetes. 31396918 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 AlteredExpression phenotype BEFREE As results, in vitro and in vivo, the OGN expression was demonstrated to reduce cell proliferation, inhibit invasion of colon cancer cells then impede cancer progression. 29499765 2018
CUI: C0038436
Disease: Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder 		0.030 Biomarker disease BEFREE Because PTSD occurs with regular frequency in Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Service Members (SMs) and combat-related injuries are associated with higher likelihood of PTSD, it is important to investigate the relationship between ketamine exposure during inpatient medical and surgical care and PTSD symptoms in OIF/OEF SMs. 31335405 2020