OGN, osteoglycin, 4969

N. diseases: 55; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017601
Disease: Glaucoma
Glaucoma 		0.010 Biomarker disease BEFREE Mimecan and activinA, which have been shown to be upregulated in models of glaucoma, were both found to be elevated in POAG TM. 16565384 2006
CUI: C0339573
Disease: Glaucoma, Primary Open Angle
Glaucoma, Primary Open Angle 		0.010 AlteredExpression disease BEFREE Mimecan and activinA, which have been shown to be upregulated in models of glaucoma, were both found to be elevated in POAG TM. 16565384 2006
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.310 Biomarker phenotype CTD_human Proteomic analysis identifies candidate proteins associated with distant recurrences in breast cancer after adjuvant chemotherapy. 17085005 2007
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 PosttranslationalModification disease BEFREE This study clearly demonstrated that absence of mimecan and upregulation of TXNDC5 are involved in the early development of colorectal cancer. 17895523 2007
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.030 PosttranslationalModification disease BEFREE This study clearly demonstrated that absence of mimecan and upregulation of TXNDC5 are involved in the early development of colorectal cancer. 17895523 2007
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression group BEFREE All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C1302401
Disease: Adenoma of large intestine
Adenoma of large intestine 		0.020 AlteredExpression disease BEFREE Differential expression of mimecan and thioredoxin domain-containing protein 5 in colorectal adenoma and cancer: a proteomic study. 17895523 2007
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression group BEFREE All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group LHGDN All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01). 17895523 2007
CUI: C0003507
Disease: Aortic Valve Stenosis
Aortic Valve Stenosis 		0.020 Biomarker disease BEFREE Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis. 18443592 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.010 Biomarker group BEFREE Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis. 18443592 2008
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.010 Biomarker disease BEFREE This is the first study showing that mimecan could serve as an excellent pathological biomarker to distinguish NSCLCs from SCLCs. 19787221 2009
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 Biomarker disease BEFREE Therefore, we hypothesize that mimecan could serve as a biomarker for differentiating various histological types of lung cancers. 19787221 2009
CUI: C0279671
Disease: Cervical Squamous Cell Carcinoma
Cervical Squamous Cell Carcinoma 		0.010 AlteredExpression disease BEFREE A differential protein pattern for SCC was, e.g. over-expressed (OE) eukaryotic translation initiation factor 3-2β, neutrophil cytosolic factor 2, annexin A6 (ANXA6), for SVC it was OE cathepsin D, γ-catenin, RAB2A, for both cancers it was OE apolipoprotein E, tropomyosin 3, HSPA8, and underexpressed cytokeratin 13, osteoglycin. 21137014 2010
CUI: C0206682
Disease: Follicular thyroid carcinoma
Follicular thyroid carcinoma 		0.010 AlteredExpression disease BEFREE Four proteins showed significant differences between FA and FTC (peroxisomal proliferator-activated receptor-γ, serum deprivation response protein, osteoglycin, and dipeptidase 1). 23751876 2013
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.310 Biomarker phenotype BEFREE Altogether, our present data first time show that PFN1, NCL, CNDP2 and OGN are novel potential biomarkers for diagnosis and therapeutic targets for laryngeal carcinoma, and PFN1 is involved in the metastasis of laryngeal carcinoma. 24587265 2014
CUI: C0003123
Disease: Anorexia
Anorexia 		0.010 Biomarker disease BEFREE Notably, mimecan-MBP also induced anorexia in A(y)/a and db/db mice. 26870797 2015
CUI: C0018801
Disease: Heart failure
Heart failure 		0.010 Biomarker disease BEFREE In human heart failure, osteoglycin is a promising biomarker for ischemic heart failure. 25520363 2015
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.010 Biomarker disease BEFREE In human heart failure, osteoglycin is a promising biomarker for ischemic heart failure. 25520363 2015
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.010 AlteredExpression disease BEFREE Adenoviral overexpression of osteoglycin in wild-type mice significantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI. 25520363 2015
CUI: C0264732
Disease: Cardiac dilatation
Cardiac dilatation 		0.010 AlteredExpression disease BEFREE Adenoviral overexpression of osteoglycin in wild-type mice significantly improved collagen quality, thereby blunting cardiac dilatation and dysfunction after MI. 25520363 2015
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 AlteredExpression disease BEFREE The present study showed for the first time that higher serum OGN levels were associated with decreased BMD and increased risk of vertebral fractures in postmenopausal women with T2DM. 27836731 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.030 Biomarker group BEFREE Our findings suggest that LIP deficiency renders tumor cell resistant to ER stress by preventing the induction of Ogn. 28383550 2017
CUI: C0038436
Disease: Post-Traumatic Stress Disorder
Post-Traumatic Stress Disorder 		0.030 Biomarker disease BEFREE Twenty-six OEF/OIF combat veterans with PTSD who had recently returned from a combat zone were block randomized to receive eight sessions of MBSR or present-centered group therapy (PCGT). 28890702 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 Biomarker group BEFREE Osteoglycin (OGN) has been noted for its implication in cardiovascular disease in recent studies. 28069703 2017