|
Neoplasm Metastasis
|
0.310 |
Biomarker
|
phenotype |
BEFREE |
Altogether, our present data first time show that PFN1, NCL, CNDP2 and OGN are novel potential biomarkers for diagnosis and therapeutic targets for laryngeal carcinoma, and PFN1 is involved in the metastasis of laryngeal carcinoma.
|
24587265 |
2014 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hence, we aim to measure the OGN expression patterns and immune cells response in colorectal cancer(CRC).
|
30037719 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
This study clearly demonstrated that absence of mimecan and upregulation of TXNDC5 are involved in the early development of colorectal cancer.
|
17895523 |
2007 |
|
Colorectal Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Patients with high expression of OGN were associated with a profound longer survival in CRC and the high serum OGN level was also indicative of fewer recurrences consistently.
|
29499765 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The present study showed for the first time that higher serum OGN levels were associated with decreased BMD and increased risk of vertebral fractures in postmenopausal women with T2DM.
|
27836731 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Another study reported that osteoglycin is a marker of low bone mineral density and vertebral fractures in women with type 2 diabetes.
|
31396918 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Receiver operator characteristic (ROC) curves were used to identify the optimal sensitivity for serum OIF.Univariate analysis showed microalbuminuria prevalence negatively correlated with OIF, 4.3% for quartile 1 (Q1) (>367.5 pg/mL), 13.7% for Q2 (320.3-367.5 pg/mL), 17.9% for Q3 (275.0-320.3 pg/mL), and 28.8% for Q4 (<275.0 pg/mL) (Ptrend < .001), as did T2DM complications.
|
30075597 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Our findings suggest that LIP deficiency renders tumor cell resistant to ER stress by preventing the induction of Ogn.
|
28383550 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Xenograft tumor models were constructed to explore the role of OGN on tumor growth in vivo.
|
31824171 |
2019 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Tumor OGN expression levels were positively associated with CD3, CD8, and PTPRC expressions in the training and testing sets from TCGA, respectively.
|
30037719 |
2018 |
|
Post-Traumatic Stress Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
To examine whether a traumatic brain injury (TBI) diagnosis was associated with increased outpatient service utilization and associated costs among Iraq and Afghanistan (Operation Enduring Freedom [OEF]/Operation Iraqi Freedom [OIF]/Operation New Dawn [OND]) War veterans with posttraumatic stress disorder (PTSD) who used Veterans Health Affairs (VHA) care in a 1-year period.
|
27022960 |
2018 |
|
Post-Traumatic Stress Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Twenty-six OEF/OIF combat veterans with PTSD who had recently returned from a combat zone were block randomized to receive eight sessions of MBSR or present-centered group therapy (PCGT).
|
28890702 |
2017 |
|
Post-Traumatic Stress Disorder
|
0.030 |
Biomarker
|
disease |
BEFREE |
Because PTSD occurs with regular frequency in Operation Iraqi Freedom/Operation Enduring Freedom (OIF/OEF) Service Members (SMs) and combat-related injuries are associated with higher likelihood of PTSD, it is important to investigate the relationship between ketamine exposure during inpatient medical and surgical care and PTSD symptoms in OIF/OEF SMs.
|
31335405 |
2020 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
Biomarker
|
disease |
BEFREE |
OGN plays a restrictive role in colorectal cancer progression by reduced activation of EGFR/AKT/Zeb-1.
|
29499765 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
This study clearly demonstrated that absence of mimecan and upregulation of TXNDC5 are involved in the early development of colorectal cancer.
|
17895523 |
2007 |
|
Malignant neoplasm of colon and/or rectum
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Hence, we aim to measure the OGN expression patterns and immune cells response in colorectal cancer(CRC).
|
30037719 |
2018 |
|
Aortic Valve Stenosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, these data implicate Ogn as a key regulator of LVM in rats, mice and humans, and suggest that Ogn modifies the hypertrophic response to extrinsic factors such as hypertension and aortic stenosis.
|
18443592 |
2008 |
|
Aortic Valve Stenosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, osteoglycin levels were higher in patients with less severe myocardial fibrosis and overall in the aortic stenosis patients osteoglycin levels negatively correlated with collagen content in the myocardium.
|
28958774 |
2018 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The proteomics analysis reveals proteins related to atherosclerosis formation including Mimecan, Ras Suppressor Protein-1 (RSUP-1) and Cathepsin D which identified as biomarker of cancerous tumors.
|
30616890 |
2019 |
|
Arteriosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of osteoglycin in atherosclerosis remains unclear.
|
29503411 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
However, the role of osteoglycin in atherosclerosis remains unclear.
|
29503411 |
2018 |
|
Atherosclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The proteomics analysis reveals proteins related to atherosclerosis formation including Mimecan, Ras Suppressor Protein-1 (RSUP-1) and Cathepsin D which identified as biomarker of cancerous tumors.
|
30616890 |
2019 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Consistently, immunofluorescence validated that OGN was preferentially expressed with CD8+ cells in both normal epithelium and cancer tissue.
|
30037719 |
2018 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
All adenoma and cancer tissues did not express mimecan, but all normal mucosa did (P < 0.01).
|
17895523 |
2007 |
|
Cardiovascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, clinical studies link osteoglycin to insulin resistance and cardiovascular disease.
|
31396918 |
2019 |