PLTP, phospholipid transfer protein, 5360

N. diseases: 62; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 GeneticVariation disease BEFREE In this review, I summarize the major progress made in the PLTP research field and emphasize its impact on lipoprotein metabolism and atherosclerosis, as well as its regulation. 29438986 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 GeneticVariation disease BEFREE In this review, I summarize the major progress made in the PLTP research field and emphasize its impact on lipoprotein metabolism and atherosclerosis, as well as its regulation. 29438986 2018
CUI: C0030662
Disease: Gambling, Pathological
Gambling, Pathological 		0.100 GeneticVariation disease GWASCAT Genome-wide association study of pathological gambling. 27315593 2016
CUI: C0202236
Disease: Triglycerides measurement
Triglycerides measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.100 GeneticVariation phenotype GWASCAT Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. 28270201 2017
CUI: C0392885
Disease: High density lipoprotein measurement
High density lipoprotein measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428472
Disease: Serum HDL cholesterol measurement
Serum HDL cholesterol measurement 		0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0523465
Disease: Serum albumin measurement
Serum albumin measurement 		0.100 GeneticVariation phenotype GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
CUI: C0523744
Disease: Lipids measurement
Lipids measurement 		0.100 GeneticVariation group GWASDB Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
CUI: C0523744
Disease: Lipids measurement
Lipids measurement 		0.100 GeneticVariation group GWASCAT Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. 19936222 2009
CUI: C0523744
Disease: Lipids measurement
Lipids measurement 		0.100 GeneticVariation group GWASCAT Genome-wide association study identifies multiple loci influencing human serum metabolite levels. 22286219 2012
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 GeneticVariation disease BEFREE Furthermore, we also checked for a synergetic association between the PLTP gene, APOE and AD. 20714154 2010
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.030 GeneticVariation group BEFREE Of interest, common PLTP variations that predict cardiovascular disease have been identified recently. 21973210 2012
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 GeneticVariation disease BEFREE Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa. 26009633 2015
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 GeneticVariation group BEFREE Triglyceride levels (P = 0.0042), diabetes (P = 7.28 × 10(-5)), paraoxonase 1 (PON1) activity (P = 0.019), statin use (P = 0.026), PLTP SNP rs4810479 (P = 6.38 × 10(-7)), and PCIF1 SNP rs181914932 (P = 0.041) were all significantly associated with PLTPa. 26009633 2015
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation disease BEFREE Plasma PLTP activity (using a phospholipid vesicles-HDL system), PLTP gene score [number of PLTP activity-decreasing alleles based on two tagging polymorphisms (rs378114 and rs60- 65904)] and waist circumference were determined in two Dutch cohorts comprising 237 patients with type 2 diabetes and 78 control subjects. 21973210 2012
CUI: C0007273
Disease: Carotid Artery Diseases
Carotid Artery Diseases 		0.020 GeneticVariation group BEFREE For rs6065904, the allele that was associated with CAAD was also associated with elevated PLTP activity in both cohorts. 19965587 2010
CUI: C0473527
Disease: Hypoalphalipoproteinemias
Hypoalphalipoproteinemias 		0.020 GeneticVariation disease BEFREE We previously demonstrated the role of a phospholipid transfer protein (PLTP) gene variation (rs2294213) in determining levels of high-density lipoprotein cholesterol (HDL-C) in hypoalphalipoproteinemia (HypoA). 19013296 2008
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.310 Biomarker phenotype CTD_human Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. 12754275 2003
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.310 Biomarker group CTD_human Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. 17952847 2007
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.310 Biomarker group BEFREE Insights into the interaction of PLTP with lipoproteins at the molecular level provide a basis to understand the PLTP-dependent lipid transfer mechanisms for dyslipidemia treatment. 29883800 2018
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Biomarker phenotype CTD_human Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). 12754275 2003
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0598784
Disease: Dyslipoproteinemias
Dyslipoproteinemias 		0.300 Biomarker phenotype CTD_human Common single-nucleotide polymorphisms act in concert to affect plasma levels of high-density lipoprotein cholesterol. 17952847 2007