PLTP, phospholipid transfer protein, 5360

N. diseases: 62; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013238
Disease: Dry Eye Syndromes
Dry Eye Syndromes 		0.200 Biomarker disease MGD
CUI: C0011847
Disease: Diabetes
Diabetes 		0.030 AlteredExpression disease BEFREE PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. 16644710 2006
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.030 AlteredExpression group BEFREE PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. 16644710 2006
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 AlteredExpression disease BEFREE PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. 16644710 2006
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 AlteredExpression disease BEFREE PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. 16644710 2006
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 AlteredExpression disease BEFREE PLTP activity is elevated in patients with diabetes, a condition with strongly elevated risk for coronary heart disease. 16644710 2006
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 AlteredExpression disease BEFREE PLTP activity and apoE were measured in patients with type 2 diabetes from the DALI (Diabetes Atorvastatin Lipid Intervention) Study, a 30-week randomized double-blind placebo-controlled trial with atorvastatin (10 and 80 mg daily). 16644710 2006
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.010 AlteredExpression disease BEFREE PLTP activity was elevated in patients with periodontitis, compared to the PLTP activity reference group (age-matched systemically healthy adults, n = 29; 18 micromol ml(-1) h(-1)vs 13 micromol ml(-1) h(-1), respectively, P = 0.002). 18826383 2008
CUI: C0031094
Disease: Periodontal Pocket
Periodontal Pocket 		0.010 AlteredExpression disease BEFREE PLTP activity inversely correlated with average periodontal pocket depth (PPD) per tooth (r(s) = -0.372; P = 0.002). 18826383 2008
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.010 AlteredExpression phenotype BEFREE PLTP levels and activity were determined in maternal and fetal sera from GDM and controls. 22090281 2012
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development; however, little is known about the regulation of PLTP. 29680823 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) is one of the major modulators of lipoprotein metabolism and atherosclerosis development; however, little is known about the regulation of PLTP. 29680823 2018
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target. 31017809 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) is one of the key regulators of lipoprotein metabolism; PLTP-deficient mice exhibit decreased apolipoprotein B (apoB)-containing lipoprotein secretion and atherosclerosis, indicating the validity of PLTP as a promising therapeutic target. 31017809 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.030 AlteredExpression group BEFREE A gene score based on 2 PLTP single nucleotide polymorphisms is associated with lower PLTP transcription and activity, an increased number of HDL particles, smaller HDL size, and decreased risk of cardiovascular disease. 20644014 2010
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 AlteredExpression phenotype BEFREE Ablation of LPL or PLTP in U251 cells resulted in the down-regulation of epithelial mesenchymal transition markers and invasion molecules matrix metalloproteinases. 27864281 2017
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease BEFREE Activity of this transfer protein in cerebrospinal fluid of patients with Alzheimer's disease is profoundly decreased and exogenous phospholipid transfer protein induces apolipoprotein E secretion by primary human astrocytes in vitro. 16680037 2006
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. 28596518 2017
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE Although plasma phospholipid transfer protein (PLTP) has been mainly studied in the context of atherosclerosis, it shares homology with proteins involved in innate immunity. 28596518 2017
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.030 AlteredExpression disease BEFREE As the macrophage is a key component of the atherosclerotic lesion and an important site of PLTP expression, we investigated the role of systemic and peripheral PLTP in macrophage cholesterol efflux and reverse cholesterol transport (RCT) in vivo. 19100548 2009
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.310 AlteredExpression phenotype LHGDN Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. 12754275 2003
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.310 Biomarker phenotype CTD_human Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. 12754275 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential. 12086920 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential. 12086920 2002
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 Biomarker disease BEFREE Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis. 12835223 2003