Dry Eye Syndromes
|
0.200 |
Biomarker
|
disease |
MGD |
|
|
|
Pulmonary Emphysema
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These observations suggest that a hypoxic stimulus occurring in emphysema may be a novel mechanism that contributes to enhanced expression of PLTP.
|
9624168 |
1998 |
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
We evaluated the influence of insulin sensitivity and of the TaqIB CETP gene polymorphism (B1B2) on plasma LCAT, CETP, and PLTP activities (measured with exogenous substrates) and their responses to hyperinsulinemia.
|
10428983 |
1999 |
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Cerebellum of 4 controls, 7 patients with DS, 5 patients with Alzheimer's disease (AD) were used for differential display and for quantification of mRNA steady state levels of the isomer PLTP-1 by blotting methods.
|
11324722 |
2001 |
Down Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the brain, phospholipids in addition are integral constituents of myelins and synaptosomes (Johnson etc) and deficient PLTP levels may account for the deteriorated functions described to occur in DS brain.
|
11324722 |
2001 |
Complete Trisomy 21 Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the brain, phospholipids in addition are integral constituents of myelins and synaptosomes (Johnson etc) and deficient PLTP levels may account for the deteriorated functions described to occur in DS brain.
|
11324722 |
2001 |
Hyperglycemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical data have recently indicated that plasma PLTP activity and mass were both higher in diabetic patients concomitant with hyperglycemia.
|
11473048 |
2001 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential.
|
12086920 |
2002 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential.
|
12086920 |
2002 |
Coronary Arteriosclerosis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease.
|
12086920 |
2002 |
Coronary heart disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease.
|
12086920 |
2002 |
Coronary Artery Disease
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease.
|
12086920 |
2002 |
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD.
|
12671035 |
2003 |
Hypertriglyceridemia
|
0.310 |
AlteredExpression
|
phenotype |
LHGDN |
Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls.
|
12754275 |
2003 |
Hypertriglyceridemia
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls.
|
12754275 |
2003 |
Insulin Resistance
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01).
|
12754275 |
2003 |
Insulin Sensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG: effects of bezafibrate therapy.
|
12754275 |
2003 |
Coronary Arteriosclerosis
|
0.030 |
Biomarker
|
disease |
BEFREE |
Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis.
|
12835223 |
2003 |
Atherosclerotic lesion
|
0.030 |
Biomarker
|
disease |
BEFREE |
However, whether PLTP might participate directly in human atherosclerotic lesion formation is unknown.
|
12835223 |
2003 |
Coronary heart disease
|
0.030 |
Biomarker
|
disease |
LHGDN |
Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.
|
14695459 |
2004 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Therefore, we studied atherosclerosis in heterozygous LDL receptor-deficient (LDLR(+/-)) mice expressing both human CETP and human PLTP.
|
14993244 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis in mouse models.
|
15258196 |
2004 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis in mouse models.
|
15258196 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phospholipid transfer protein (PLTP) deficiency reduced apo B production in apo E-/- mice, as well as oxidative stress in four models of mouse atherosclerosis.
|
15694928 |
2005 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phospholipid transfer protein (PLTP) deficiency reduced apo B production in apo E-/- mice, as well as oxidative stress in four models of mouse atherosclerosis.
|
15694928 |
2005 |