PLTP, phospholipid transfer protein, 5360

N. diseases: 62; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013238
Disease: Dry Eye Syndromes
Dry Eye Syndromes 		0.200 Biomarker disease MGD
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.010 AlteredExpression disease BEFREE These observations suggest that a hypoxic stimulus occurring in emphysema may be a novel mechanism that contributes to enhanced expression of PLTP. 9624168 1998
CUI: C0020459
Disease: Hyperinsulinism
Hyperinsulinism 		0.010 Biomarker disease BEFREE We evaluated the influence of insulin sensitivity and of the TaqIB CETP gene polymorphism (B1B2) on plasma LCAT, CETP, and PLTP activities (measured with exogenous substrates) and their responses to hyperinsulinemia. 10428983 1999
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 AlteredExpression disease BEFREE Cerebellum of 4 controls, 7 patients with DS, 5 patients with Alzheimer's disease (AD) were used for differential display and for quantification of mRNA steady state levels of the isomer PLTP-1 by blotting methods. 11324722 2001
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.010 AlteredExpression disease BEFREE In the brain, phospholipids in addition are integral constituents of myelins and synaptosomes (Johnson etc) and deficient PLTP levels may account for the deteriorated functions described to occur in DS brain. 11324722 2001
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.010 AlteredExpression disease BEFREE Clinical data have recently indicated that plasma PLTP activity and mass were both higher in diabetic patients concomitant with hyperglycemia. 11473048 2001
CUI: C4521042
Disease: Complete Trisomy 21 Syndrome
Complete Trisomy 21 Syndrome 		0.010 AlteredExpression disease BEFREE In the brain, phospholipids in addition are integral constituents of myelins and synaptosomes (Johnson etc) and deficient PLTP levels may account for the deteriorated functions described to occur in DS brain. 11324722 2001
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential. 12086920 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE At lease two underlined mechanisms are involved in the reduction of atherosclerosis in PLTP deficient status, 1) reduction of apoB-containing lipoprotein production and levels; and 2) increase of anti-oxidation potential. 12086920 2002
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 AlteredExpression disease BEFREE Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease. 12086920 2002
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 AlteredExpression disease BEFREE Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease. 12086920 2002
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.030 AlteredExpression disease BEFREE Human studies indicated that PLTP activity positively correlated with aging, obesity, diabetes and coronary artery disease. 12086920 2002
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.310 AlteredExpression phenotype LHGDN Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. 12754275 2003
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.310 Biomarker phenotype CTD_human Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. 12754275 2003
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Biomarker phenotype CTD_human Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). 12754275 2003
CUI: C0920563
Disease: Insulin Sensitivity
Insulin Sensitivity 		0.300 Biomarker phenotype CTD_human Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG: effects of bezafibrate therapy. 12754275 2003
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.050 Biomarker disease BEFREE Comparison between brain tissues from patients with Alzheimer's disease (AD) and nonAD subjects revealed a significant increase (P = 0.02) in PLTP levels in brain tissue homogenates and increased PLTP immunostaining in AD. 12671035 2003
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.030 Biomarker disease BEFREE Cell-associated and extracellular phospholipid transfer protein in human coronary atherosclerosis. 12835223 2003
CUI: C4703473
Disease: Atherosclerotic lesion
Atherosclerotic lesion 		0.030 Biomarker disease BEFREE However, whether PLTP might participate directly in human atherosclerotic lesion formation is unknown. 12835223 2003
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis in mouse models. 15258196 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease LHGDN Therefore, we studied atherosclerosis in heterozygous LDL receptor-deficient (LDLR(+/-)) mice expressing both human CETP and human PLTP. 14993244 2004
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE We reported that phospholipid transfer protein (PLTP) deficiency decreased atherosclerosis in mouse models. 15258196 2004
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 Biomarker disease LHGDN Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases. 14695459 2004
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) deficiency reduced apo B production in apo E-/- mice, as well as oxidative stress in four models of mouse atherosclerosis. 15694928 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE Phospholipid transfer protein (PLTP) deficiency reduced apo B production in apo E-/- mice, as well as oxidative stress in four models of mouse atherosclerosis. 15694928 2005