Glioma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Finally, rescue experiments were conducted to ascertain the involvement of CYTOR in UPF1-regulated progression of glioma.
|
31799670 |
2019 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Upregulation of SNHG6 expression induced RKO and HCT116 cell proliferation as well as RKO cell metastasis, while downregulation of SNHG6 expression supressed the proliferation and metastasis of RKO cells and tumor growth <i>in vivo.</i> UPF1 was upregulated and ZEB1 was decreased when SNHG6 knockdown, regulating the TGF-β/Smad pathway and inducing EMT respectively.
|
30662328 |
2019 |
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Accordingly, restoring NR4A1 expression ameliorated the effects of NR4A1AS knockdown on tumor growth and metastasis of CRC cells <i>in vitro</i> and <i>in vivo</i> Thus, we conclude that NR4A1AS up-regulates NR4A1 expression by forming RNA-RNA complexes and blocking UPF1-mediated mRNA destabilization, and it functions in tumor growth and metastasis of CRC cells at least partly through regulating NR4A1, suggesting that NR4A1AS might be as a potential target for RNA-based anti-CRC drug studies.
|
31253658 |
2019 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Collectively, PKP1/3-associated RBPs FXR1 and UPF1 may have a functional role in prostate cancer progression and metastasis and highlight the potential importance of posttranscriptional regulation of gene expression and nonsense-mediated decay in cancer.
|
23881279 |
2013 |
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
|
31253658 |
2019 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of UCA1 ameliorated the effect of UPF1 knock down on HCC growth and invasion.
|
31040354 |
2019 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MTT, cell cycle, apoptosis and transwell assays were performed to examine the effects of UPF1 on cell cycle progression, cell proliferation, apoptosis, migration and invasion.
|
28942451 |
2017 |
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The impact of NMD activity was also investigated in primary MSI CRCs by quantifying the expression of several mRNAs relative to their mutational status and to endogenous UPF1 and UPF2 expression.
|
18612427 |
2008 |
Choroideremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
There was no correlation between CHM mRNA expression and genotype, phenotype or UPF1 transcript levels.
|
30689859 |
2019 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
Retinoblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Key proteins, including cluster of differentiation (CD)31 (platelet endothelial cell adhesion molecule‑1), Vimentin, CD44, PCNA, Ki‑67, N‑Cadherin, Survivin, P53, Met and retinoblastoma exhibited a significant association with UPF1.
|
30628676 |
2019 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we elucidated the function and possible effect and molecular mechanisms of lncRNA-Linc-00313 on the biological behaviors of glioblastoma cells as well as UPF1 function as a RNA-binding protein to enhance its stability.
|
31427569 |
2019 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A novel lncRNA NR4A1AS up-regulates orphan nuclear receptor NR4A1 expression by blocking UPF1-mediated mRNA destabilization in colorectal cancer.
|
31253658 |
2019 |
Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UPF1 expression was detected by qRT-PCR, western blotting, and immunohistochemistry in dextran sulfate sodium-induced colitis in mice.
|
29959727 |
2018 |
Ulcerative Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study aimed to validate the underlying mechanism of UPF1 in UC.
|
29959727 |
2018 |
Microcephaly
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We propose that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology <i>in vivo</i><b>IMPORTANCE</b> Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly.
|
30401782 |
2018 |
Thalassemia
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We developed a human cellular model of the β<sup>0</sup>39 thalassemia mutation with UPF-1 suppressed and showing a partial NMD suppression.
|
29764417 |
2018 |
Zika Virus Infection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We propose that ZIKV, via the capsid protein, has evolved a strategy to lower UPF1 levels and dampen antiviral activities of NMD, which in turn contributes to neuropathology <i>in vivo</i><b>IMPORTANCE</b> Zika virus (ZIKV) is a significant global health threat, as infection has been linked to serious neurological complications, including microcephaly.
|
30401782 |
2018 |
Autistic Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These data highlight a new, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or translation of mRNAs that are critical for synaptic plasticity.<b>SIGNIFICANCE STATEMENT</b> The elongation and/or termination steps of mRNA translation are emerging as important control points in mGluR-LTD, a form of synaptic plasticity that is compromised in a severe monogenic form of autism, Fragile X Syndrome.
|
28821679 |
2017 |
Epilepsy, Temporal Lobe
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Upf1 protein levels were also higher in resected hippocampus from patients with intractable temporal lobe epilepsy.
|
28128343 |
2017 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry and qRT-PCR analyses were used to detect the expression levels of UPF1 and MALAT1 in gastric cancer and adjacent normal tissues.
|
28942451 |
2017 |
Status Epilepticus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunoprecipitation of Upf1-bound RNA from the cytoplasmic and synaptosomal compartments followed by RNA sequencing identified unique populations of NMD-associated transcripts and altered levels after status epilepticus, including known substrates such as Arc as well as novel targets including Inhba and Npas4.
|
28128343 |
2017 |
Hallopeau-Siemens Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Amlexanox increased COL7A1 transcript and the phosphorylation of UPF-1, an RNA helicase associated with nonsense-mediated mRNA decay, suggesting that amlexanox inhibits nonsense-mediated mRNA decay in cells from patients with RDEB that respond to read-through treatment.
|
28549954 |
2017 |