|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Therefore, we report that MIIP is a novel potential tumour suppressor gene in CRC.
|
27741356 |
2017 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
|
27741356 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.
|
27741356 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA-this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.
|
29038521 |
2017 |
|
Colorectal Carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Moreover, clinical analyses indicate the level of MIIP-S303 phosphorylation correlates with colorectal cancer (CRC) metastasis and prognosis.
|
29038521 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.
|
29038521 |
2017 |
|
Secondary Neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings uncover an unidentified mechanism underlying the precise regulation of NF-κB by EGF, and highlight the critical role of nuclear MIIP in tumor metastasis.In colorectal cancer, EGFR signalling is implicated in metastasis.
|
29038521 |
2017 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Moreover, the dysregulated miR-646 and MIIP expression was correlated with advanced tumor stage, lymphatic invasion, metastasis and shorter overall survival in PC patients.
|
29343850 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer.
|
29343850 |
2018 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with paracarcinoma tissues, MIIP was downregulated in PC tissues.
|
29343850 |
2018 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared with paracarcinoma tissues, MIIP was downregulated in PC tissues.
|
29343850 |
2018 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The MIIP gene was transfected into NPC 5-8F and CNE2 cells.
|
29805670 |
2018 |
|
Neoplasms
|
0.060 |
AlteredExpression
|
group |
BEFREE |
Ectopic expression of MIIP in GC cell lines BGC823 and HGC27 induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest and inhibited cell proliferation, colony formation, migration and invasion in vitro, as well as the growth of GC xenografts and metastasis of tumors in vivo.
|
30588008 |
2018 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
MIIP is downregulated in gastric cancer and its forced expression inhibits proliferation and invasion of gastric cancer cells in vitro and in vivo.
|
30588008 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of MIIP in GC cell lines BGC823 and HGC27 induced G<sub>0</sub>/G<sub>1</sub> cell cycle arrest and inhibited cell proliferation, colony formation, migration and invasion in vitro, as well as the growth of GC xenografts and metastasis of tumors in vivo.
|
30588008 |
2018 |
|
Tumor Progression
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MIIP is associated with cancer progression in various cancers.
|
30588008 |
2018 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Higher level of MIIP in GC tissues predicts better survival in patients.
|
30588008 |
2018 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Higher level of MIIP in GC tissues predicts better survival in patients.
|
30588008 |
2018 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
Transwell and wound-healing assays were used to detect cell invasion and migration after MIIP overexpression.
|
31078343 |
2019 |
|
Malignant neoplasm of breast
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MTT assay and colony formation assay were used to detect cell viability of breast cancer cells after MIIP overexpression.
|
31078343 |
2019 |
|
Breast Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MTT assay and colony formation assay were used to detect cell viability of breast cancer cells after MIIP overexpression.
|
31078343 |
2019 |
|
Luminal A Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Breast cancer tissues of HER2 overexpression and Basal-like were more significant than Luminal A and Luminal B. MIIP was obviously downregulated and IGFBP2 was upregulated in MDA-MB-231, SKBR3 and MCF-7 versus MCF-10A especially in MDA-MB-231.
|
31078343 |
2019 |
|
Luminal B Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Breast cancer tissues of HER2 overexpression and Basal-like were more significant than Luminal A and Luminal B. MIIP was obviously downregulated and IGFBP2 was upregulated in MDA-MB-231, SKBR3 and MCF-7 versus MCF-10A especially in MDA-MB-231.
|
31078343 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Our study further emphasized the tumor suppressive role of MIIP and illustrated a novel mechanism.
|
31092266 |
2019 |