SERPINB3, serpin family B member 3, 6317

N. diseases: 101; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.320 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.310 Biomarker disease CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0032927
Disease: Precancerous Conditions
Precancerous Conditions 		0.300 Biomarker group CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0282313
Disease: Condition, Preneoplastic
Condition, Preneoplastic 		0.300 Biomarker disease CTD_human Comparative proteomic analysis of esophageal squamous cell carcinoma. 15986332 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.040 Biomarker disease BEFREE We recently found that the squamous cell carcinoma antigens 1 (SCCA1) and SCCA2 are novel biomarkers of bronchial asthma, downstream of IL-4 and IL-13. 16238792 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.040 AlteredExpression disease LHGDN We propose that: (i) IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and (ii) by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma. 15677460 2005
CUI: C0004096
Disease: Asthma
Asthma 		0.040 AlteredExpression disease BEFREE We propose that: (i) IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and (ii) by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma. 15677460 2005
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.040 Biomarker disease BEFREE We examined whether SCCA1 and SCCA2 could also serve as biomarkers of AD, reflecting its Th2-type immune responses, and whether the expression level of SCCA was correlated with clinical severity of AD. 16238792 2005
CUI: C0013595
Disease: Eczema
Eczema 		0.040 Biomarker disease BEFREE We examined whether SCCA1 and SCCA2 could also serve as biomarkers of AD, reflecting its Th2-type immune responses, and whether the expression level of SCCA was correlated with clinical severity of AD. 16238792 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.040 Biomarker disease LHGDN Hydrophobicity of reactive site loop of SCCA1 affects its binding to hepatitis B virus. 15902720 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.040 Biomarker disease BEFREE Hydrophobicity of reactive site loop of SCCA1 affects its binding to hepatitis B virus. 15902720 2005
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE In addition, in vitro invasion assay showed that SCCA1 and SCCA2 significantly promoted the activity of cell invasion. 16211231 2005
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 AlteredExpression phenotype LHGDN We propose that: (i) IL-4- and IL-13-stimulated SCCA gene expression is mediated via STAT-1 and STAT-6 activation, and (ii) by suppressing the production, and most likely by interfering with the signaling of these cytokines, UG inhibits SCCA gene expression associated with airway inflammation in asthma. 15677460 2005
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 AlteredExpression disease BEFREE Uteroglobin suppresses SCCA gene expression associated with allergic asthma. 15677460 2005
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 AlteredExpression disease BEFREE High SerpinB3 expression levels, invariably associated with chemoresistance, had contrasting prognostic impact in untreated squamous cell carcinomas (hazard ratio [HR], 0.43; 95% CI, 0.18 to 0.93) or adenocarcinomas (HR, 2.09; 95% CI, 1.03 to 4.72). 16549823 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 AlteredExpression disease LHGDN Squamous cell carcinoma-antigen messenger RNA level in peripheral blood predicts recurrence after resection in patients with esophageal squamous cell carcinoma. 16701102 2006
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.400 AlteredExpression disease LHGDN Molecular detection of squamous cell carcinoma antigen transcripts in peripheral blood of cancer patients. 16681421 2006
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Investigation of the pathogenic and prognostic significance of SerpinB3 was performed in 251 primary tumors, with 64 regional lymph node pairs, from chemotherapy-naïve NSCLC patients using immunohistochemistry. 16549823 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.040 AlteredExpression group BEFREE High SerpinB3 expression levels, invariably associated with chemoresistance, had contrasting prognostic impact in untreated squamous cell carcinomas (hazard ratio [HR], 0.43; 95% CI, 0.18 to 0.93) or adenocarcinomas (HR, 2.09; 95% CI, 1.03 to 4.72). 16549823 2006
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.040 AlteredExpression disease BEFREE HNSCC cell lines were transfected with a mammalian expression vector with SCCA1 cDNA. 16155915 2006
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.030 AlteredExpression disease BEFREE SerpinB3 protein expression was correlated with clinical response in PBC-treated NSCLC patients (P = .045). 16549823 2006
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.030 AlteredExpression phenotype BEFREE However, SCCA1 expression significantly inhibited the in vitro invasion in matrigel assays. 16155915 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.020 Biomarker disease BEFREE Squamous cell carcinoma antigens SCCA1 and SCCA2 are highly homologous serine proteinase inhibitors which have been widely utilized as serological markers for squamous cell cancers, but it has recently been demonstrated that only SCCA2 is truly specific for certain forms of lung cancer. 16710347 2006
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.020 Biomarker disease BEFREE Squamous cell carcinoma antigens SCCA1 and SCCA2 are highly homologous serine proteinase inhibitors which have been widely utilized as serological markers for squamous cell cancers, but it has recently been demonstrated that only SCCA2 is truly specific for certain forms of lung cancer. 16710347 2006
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.020 Biomarker disease BEFREE Squamous cell carcinoma antigens SCCA1 and SCCA2 are highly homologous serine proteinase inhibitors which have been widely utilized as serological markers for squamous cell cancers, but it has recently been demonstrated that only SCCA2 is truly specific for certain forms of lung cancer. 16710347 2006