TNMD, tenomodulin, 64102

N. diseases: 86; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032580
Disease: Adenomatous Polyposis Coli
Adenomatous Polyposis Coli 		0.010 GeneticVariation disease BEFREE TEM studies suggest that the entropic barrier associated with filament assembly (amyloid fibril formation) is high in vitro, amyloid being defined by the laterally assembled four filament structure observed by Blake upon isolation of "fibrils" from the eye of a FAP patient. 10521263 1999
CUI: C2751492
Disease: AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED
AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED 		0.010 GeneticVariation disease BEFREE TEM studies suggest that the entropic barrier associated with filament assembly (amyloid fibril formation) is high in vitro, amyloid being defined by the laterally assembled four filament structure observed by Blake upon isolation of "fibrils" from the eye of a FAP patient. 10521263 1999
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE TEM (294/324, 90.7%) and ROB-1 (30/324, 9.3%) prevalence rates among 324 isolates of H. influenzae obtained from across Canada in 1997-1998 were similar (P > 0.05) to previously published reports.However, 66. 10837442 2000
CUI: C0018995
Disease: Hemochromatosis
Hemochromatosis 		0.010 Biomarker disease BEFREE This very early stage of hemochromatosis was confirmed by TEM and EELS for iron accumulation inside hepatocytic lysosomes and residual bodies. 12028655 2002
CUI: C3469186
Disease: HEMOCHROMATOSIS, TYPE 1
HEMOCHROMATOSIS, TYPE 1 		0.010 Biomarker disease BEFREE This very early stage of hemochromatosis was confirmed by TEM and EELS for iron accumulation inside hepatocytic lysosomes and residual bodies. 12028655 2002
CUI: C0302361
Disease: Disease caused by Shigella sonnei
Disease caused by Shigella sonnei 		0.010 Biomarker disease BEFREE Epidemiology of nalidixic acid resistance and TEM-1- and TEM-52-mediated ampicillin resistance of Shigella sonnei isolates obtained in Korea between 1980 and 2000. 14638472 2003
CUI: C0004610
Disease: Bacteremia
Bacteremia 		0.010 GeneticVariation disease BEFREE Bacteremia due to Klebsiella pneumoniae isolates producing the TEM-52 extended-spectrum beta-lactamase: treatment outcome of patients receiving imipenem or ciprofloxacin. 14699457 2004
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Furthermore, the transduction of either Ad-shTeM or Ad-shChM-I in human melanoma cells resulted in suppression of tumor growth in association with decreased vessel density in vivo. 15150318 2004
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.010 Biomarker phenotype BEFREE Enteropathogenic Escherichia coli strains carrying genes encoding the PER-2 and TEM-116 extended-spectrum beta-lactamases isolated from children with diarrhea in Uruguay. 15956426 2005
CUI: C0017638
Disease: Glioma
Glioma 		0.010 Biomarker disease BEFREE Remarkably, TEM knockout completely prevented human glioma neovascularization in the mouse brain and induced substantial tumor regression. 16169466 2005
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.070 Biomarker group BEFREE During a previous survey, five extended-spectrum beta-lactamase (ESBL)-producing enterobacteria (ESBLE) (two Enterobacter aerogenes isolates expressing TEM-24 b, two Escherichia coli isolates expressing TEM-21 or TEM-24 b, and one Klebsiella pneumoniae isolate expressing SHV-4/TEM-15) responsible for urinary tract infections (UTIs) were found among 1,584 strains collected from community patients. 16207960 2005
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.010 Biomarker group BEFREE The findings demonstrate the importance of TEM studies of lung biopsies from infants with CSD as it is a critical adjunct in the diagnosis of neonatal lung disease and in defining the underlying cellular defects. 16316951 2006
CUI: C0028754
Disease: Obesity
Obesity 		0.070 Biomarker disease BEFREE Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study. 17495183 2007
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men. 17495183 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.020 GeneticVariation phenotype BEFREE These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men. 17495183 2007
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.020 GeneticVariation phenotype LHGDN These results suggest that TNMD polymorphisms are associated with adiposity and also with glucose metabolism and conversion from IGT to T2D in men. 17495183 2007
CUI: C0011847
Disease: Diabetes
Diabetes 		0.010 Biomarker disease BEFREE Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study. 17495183 2007
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.010 Biomarker group BEFREE Tenomodulin is associated with obesity and diabetes risk: the Finnish diabetes prevention study. 17495183 2007
CUI: C0028754
Disease: Obesity
Obesity 		0.070 GeneticVariation disease BEFREE We have reported that the genetic variation of the tenomodulin gene (TNMD) is associated with the risk of type 2 diabetes (T2DM), central obesity, and impaired glucose metabolism and the TNMD mRNA levels correlate with serum and mRNA levels of inflammatory markers. 18580688 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 GeneticVariation disease BEFREE We have reported that the genetic variation of the tenomodulin gene (TNMD) is associated with the risk of type 2 diabetes (T2DM), central obesity, and impaired glucose metabolism and the TNMD mRNA levels correlate with serum and mRNA levels of inflammatory markers. 18580688 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.070 GeneticVariation disease BEFREE We have reported that the sequence variation in the tenomodulin (TNMD) gene is associated with the risk of type 2 diabetes (T2DM), central obesity and serum levels of systemic immune mediators in the Finnish Diabetes Prevention Study (DPS), which is a longitudinal lifestyle intervention study on 522 middle-aged persons with impaired glucose tolerance (IGT). 18982016 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.040 Biomarker disease BEFREE To further explore the putative mechanisms linking TNMD to T2DM and metabolic syndrome, we studied the associations of TNMD sequence variation with lipid abnormalities characteristic to metabolic syndrome. 18982016 2008
CUI: C0271650
Disease: Impaired glucose tolerance
Impaired glucose tolerance 		0.020 GeneticVariation phenotype BEFREE We have reported that the sequence variation in the tenomodulin (TNMD) gene is associated with the risk of type 2 diabetes (T2DM), central obesity and serum levels of systemic immune mediators in the Finnish Diabetes Prevention Study (DPS), which is a longitudinal lifestyle intervention study on 522 middle-aged persons with impaired glucose tolerance (IGT). 18982016 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.020 Biomarker disease BEFREE To further explore the putative mechanisms linking TNMD to T2DM and metabolic syndrome, we studied the associations of TNMD sequence variation with lipid abnormalities characteristic to metabolic syndrome. 18982016 2008
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 GeneticVariation disease BEFREE Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration. 19381347 2009