TNMD, tenomodulin, 64102

N. diseases: 86; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 GeneticVariation disease BEFREE Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort. 19524323 2011
CUI: C0028754
Disease: Obesity
Obesity 		0.070 AlteredExpression disease BEFREE The aim of this study was to investigate TNMD tissue distribution and TNMD gene expression in human adipose tissue in relation to obesity and metabolic disease. 19602561 2009
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.010 AlteredExpression group BEFREE The aim of this study was to investigate TNMD tissue distribution and TNMD gene expression in human adipose tissue in relation to obesity and metabolic disease. 19602561 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.070 Biomarker disease BEFREE In this review, the potential mechanisms that could link TNMD with the pathogenesis of obesity and related disorders are discussed. 20429799 2010
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 GeneticVariation disease BEFREE We have reported modest association between TNMD sequence variation and different obesity-related phenotypes, including anthropometric measurements, inflammation, glucose and lipid metabolism, and age-related macular degeneration. 20429799 2010
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.060 Biomarker group BEFREE Our recent work has shown that breast cancer cell adhesion to vascular endothelial cells activates endothelial MMP-2, promoting tumor cell transendothelial migration (TEM(E)). 20571065 2010
CUI: C0276640
Disease: Transmissible mink encephalopathy
Transmissible mink encephalopathy 		0.050 GeneticVariation disease BEFREE Three isolates harbored both bla(TEM-34(IRT-6)) and bla(CTX-M-15). bla(SHV-12) was identified either alone or with bla(CTX-M-15) in a single isolate. 21288137 2011
CUI: C0008354
Disease: Cholera
Cholera 		0.010 GeneticVariation disease BEFREE Ten selected cholera strains were PCR positive for the SXT element, harbored mutations in the quinolone resistance-determining regions of GyrA (Ser83-Ile) and ParC (Ser85-Leu), and produced TEM-63 β-lactamase. 21653763 2011
CUI: C0004659
Disease: Bacteriuria
Bacteriuria 		0.010 AlteredExpression phenotype BEFREE Outbreak caused by Proteus mirabilis isolates producing weakly expressed TEM-derived extended-spectrum β-lactamase in spinal cord injury patients with recurrent bacteriuria. 21888562 2011
CUI: C0009782
Disease: Connective Tissue Diseases
Connective Tissue Diseases 		0.010 Biomarker group BEFREE The molecular disorder of myxomatous degeneration appears to consist of a connective tissue disorder with altered extracellular matrix status and involves the action of matrix metalloproteinase, cysteine endoproteases, and tenomodulin. 22248324 2012
CUI: C0002066
Disease: Alkaptonuria
Alkaptonuria 		0.020 Biomarker disease BEFREE Congo Red, Thioflavin-T staining and TEM were performed to assess amyloid presence in AKU specimens (cartilage, synovia, periumbelical fat, salivary gland) and in HGA-treated human chondrocytes and cartilage. 22850426 2012
CUI: C4552766
Disease: Miscarriage
Miscarriage 		0.010 Biomarker disease BEFREE As far as is known, this is the first study to include gene sequencing, TEM, cytogenetic analysis and sperm DNA fragmentation in a case of SMS and also to report recurrent miscarriage related to this specific condition. 23273756 2013
CUI: C0042029
Disease: Urinary tract infection
Urinary tract infection 		0.070 Biomarker group BEFREE We, therefore, determined the prevalence and co-resistance of PA and non-PA ESBL-E. coli in community-acquired and nosocomial urinary tract infections in humans and bla CTX-M-1 and bla TEM-52 isolates from poultry. 23519865 2013
CUI: C0262655
Disease: Recurrent urinary tract infection
Recurrent urinary tract infection 		0.040 Biomarker disease BEFREE We, therefore, determined the prevalence and co-resistance of PA and non-PA ESBL-E. coli in community-acquired and nosocomial urinary tract infections in humans and bla CTX-M-1 and bla TEM-52 isolates from poultry. 23519865 2013
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 Biomarker group BEFREE In the era of genetics and molecular medicine TEM continues to contribute significant clinical and pathogenetic insights in kidney disease. 23876007 2013
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.010 Biomarker disease BEFREE Absolute CD38 bright CD8+ TEM of > 35 cells/μL predicted aGVHD at a median of 8 days (range, 1 to 34) before aGVHD onset with a sensitivity of 82.6% and specificity of 91.6%. 25881755 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.070 Biomarker disease BEFREE Our data suggest that TNMD acts as a protective factor in visceral adipose tissue to alleviate insulin resistance in obesity. 26880110 2016
CUI: C0276640
Disease: Transmissible mink encephalopathy
Transmissible mink encephalopathy 		0.050 Biomarker disease BEFREE Isolates were screened for the presence of the β-lactamase-TEM (BlaTEM) and β-lactamase-cfxA genes using Polymerase Chain Reaction (PCR). 27119762 2016
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.010 Biomarker disease BEFREE Temozolomide plus radiotherapy (TEM+RAD) is the most common treatment for newly diagnosed GBM. 27296952 2016
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.010 Biomarker disease BEFREE Temozolomide plus radiotherapy (TEM+RAD) is the most common treatment for newly diagnosed GBM. 27296952 2016
CUI: C0343401
Disease: MRSA - Methicillin resistant Staphylococcus aureus infection
MRSA - Methicillin resistant Staphylococcus aureus infection 		0.010 Biomarker disease BEFREE Nasal MRSA carriage was detected in 72 of 85 (84.7%) farmers and five of 84 (6.0%) farmers carried ESBL-E. ESBL-Escherichia coli isolates from farmers belonged to MLST STs/ESBL-genes ST10/CTX-M-1, ST196/TEM-52, ST278/TEM-52, ST410/CTX-M-15 and ST453/CTX-M-1. 27328620 2017
CUI: C0002066
Disease: Alkaptonuria
Alkaptonuria 		0.020 Biomarker disease BEFREE Furthermore, in order to observe the ultrastructural features of AKU chondrocytes we have performed TEM analysis, focusing on the Golgi apparatus structure and, to demonstrate that pigmented areas in AKU cartilage are correspondent to areas of oxidation, 4-HNE presence has been evaluated by means of immunofluorescence.. 27454006 2017
CUI: C0018081
Disease: Gonorrhea
Gonorrhea 		0.010 Biomarker disease BEFREE Gonococcal Antimicrobial Susceptibility and the Prevalence of bla<sub>TEM-1</sub> and bla<sub>TEM-135</sub> Genes in Neisseria gonorrhoeae Isolates from Thailand. 27580580 2017
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.010 Biomarker disease BEFREE Both SEM and TEM show a number of abnormal features in the anterior lens epithelium of cataract patients with RP. 27679403 2017
CUI: C0086543
Disease: Cataract
Cataract 		0.010 Biomarker disease BEFREE Both SEM and TEM show a number of abnormal features in the anterior lens epithelium of cataract patients with RP. 27679403 2017