|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
|
16642437 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The current study set three questions: Firstly, whether the high expressing loci of the SLC6A4 polymorphisms, 5-HTTLPR + rs25531, rs25532 and rs16965628 are associated with family-based (n = 164 trios) and case-control OCD (n = 186, 152, respectively).
|
29102815 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, a significant difference was found between 5-HTT rs16965628 polymorphism and OCD (p=0.025, OR=3.43, 95% CI 1.41-10.35).
|
25751280 |
2015 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura.
|
17101915 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.
|
15172105 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since SSRIs act on the serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD.
|
11602033 |
2001 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A total of 1991 participants with OCD and their 5-HTTLPR allele status were examined.
|
25896187 |
2015 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset.
|
30554102 |
2019 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The promoter region of the serotonin transporter gene (SLC6A4) shows a 22-bp tandem repeat polymorphism, indicated as polymorphism C, that has been associated to depression, obsessive-compulsive disorder, memory impairment, and anxiety.
|
18490109 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD.
|
17503984 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD.
|
10523819 |
1999 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA).
|
22665263 |
2013 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin transporter (hSERT) gene is a promising candidate for mediating the genetic susceptibility for various psychiatric conditions such as mood and obsessive-compulsive disorders.
|
10089018 |
1999 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The comparison of serotonin transporter linked polymorphic region (5-HTTLPR) in 102 OCD patients and 223 controls showed an increased L-allele frequency but no difference was observed when rs25531 was included.
|
30121542 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD.
|
17943026 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD.
|
18186076 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In a sample of Caucasian OCD patients, we explored the link between decision-making and the 5-HTTLPR.
|
18603313 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Subgroups based on the age of OCD onset, gender, familiality, factor analysis-derived symptom dimensions, or comorbidity with other psychiatric disorders failed to identify SLC6A4- or BDNF-associated phenotypes, with one exception of overall number of comorbid anxiety disorders being significantly associated with 5-HTTLPR/rs25531.
|
17375136 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The goal of this study was to examine relationships between OCD symptom dimensions and 5-HTTLPR.
|
16583440 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed whole blood serotonin (5-HT) concentration, platelet 5-HT transporter (5-HTT) and 5-HT2A receptor-binding characteristics, and platelet inositol trisphosphate (IP3) content in a sample of OCD probands (n = 48) and their unaffected parents (n = 65), and compared them with sex- and age-matched controls (n = 113).
|
15886722 |
2005 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the aims of this study were to investigate the associations between 5-HT transporter polymorphism and OCD.
|
16220023 |
2005 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although we did not observe any statistically significant association between the HTR2A gene polymorphisms and OCD or its clinical features, SLC6A4 STin2 polymorphism was significantly more common among OCD patients as compared to health controls.
|
29331882 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD.
|
28576508 |
2017 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Within autism, rare hSERT coding variants associate with rigid-compulsive traits, suggesting both phenotypic overlap with OCD and a shared relationship with disrupted 5-HT signalling.
|
18957375 |
2009 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin (5-hydroxytryptamine, 5-HT) transporter (hSERT, SLC6A4) figures prominently in the etiology and treatment of many prevalent neurobehavioral disorders including anxiety, alcoholism, depression, autism, and obsessive-compulsive disorder (OCD).
|
19179283 |
2009 |