|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A total of 1991 participants with OCD and their 5-HTTLPR allele status were examined.
|
25896187 |
2015 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although findings to date are mixed, serotonin transporter polymorphism 5-HTTLPR and HTR2A polymorphism rs6311 (or rs6313) are most consistently associated with OCD.
|
28576508 |
2017 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although we did not observe any statistically significant association between the HTR2A gene polymorphisms and OCD or its clinical features, SLC6A4 STin2 polymorphism was significantly more common among OCD patients as compared to health controls.
|
29331882 |
2018 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
By using random effects model, data from these studies were pooled to compare the genotypes and allelic distribution of the 5-HTTLPR polymorphism between OCD patients and control subjects.
|
17291658 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Following on from previous work by our group where we showed that early onset anorexia nervosa (AN) and obsessive-compulsive disorder (OCD) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (SLC6A4, 5HTR2A, 5HTR2C, TPH2, SLC18A1), in a common phenotype such as very-early age of onset.
|
30554102 |
2019 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Further meta-analyses based on individual patient data would be helpful in determining whether age of OCD onset, gender and the presence of comorbid illness (e.g., tics) moderates the relationship between 5-HTTLPR and OCD.
|
18186076 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-based testing of rs25532 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus association with OCD in a large case-control sample.
|
18055562 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Haplotype-based testing of rs25532 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus association with OCD in a large case-control sample.
|
18055562 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD.
|
17943026 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, a significant difference was found between 5-HTT rs16965628 polymorphism and OCD (p=0.025, OR=3.43, 95% CI 1.41-10.35).
|
25751280 |
2015 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, taking in account OCD phenotypes, we found indication towards an association of the 5-HTTLPR S-allele with female OCD patients, and the 5-HT2A G-allele and GG genotype with patients with a positive family history of OCD and an early onset of disease.
|
16443280 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
In a sample of Caucasian OCD patients, we explored the link between decision-making and the 5-HTTLPR.
|
18603313 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the main meta-analysis, OCD was associated with serotonin-related polymorphisms (5-HTTLPR and HTR2A) and, in males only, with polymorphisms involved in catecholamine modulation (COMT and MAOA).
|
22665263 |
2013 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this cross-sectional study, we have examined the allelic and genotypic frequencies of a Val-158-Met substitution in the COMT gene, a 44-base pair (bp) length variation in the regulatory region of the serotonin transporter gene (5-HTTLPR) and the T102C and C516T variants in the serotonin receptor type 2A (5HT2A) gene in 79 OCD patients and 202 control subjects.
|
15005715 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Likewise, the higher expressing LAC haplotype (5-HTTLPR/rs25531/rs25532) was more frequent in TD probands than in controls (P = 0.024; OR, 1.33) and also in the TD alone group versus the TD plus OCD group (P = 0.0013; OR, 2.14).
|
23630162 |
2013 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.
|
15172105 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and OCD.
|
12082589 |
2002 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data provide supporting evidence of an association between the STin2 VNTR polymorphism of the SLC6A4 gene and OCD.
|
18191318 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data show that genetic variation in the SLC6A4 gene regulatory region may not have a significant effect on OCD in the present population.
|
21245616 |
2010 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Results confirmed that OCD is associated with polymorphisms of 5-HTTLPR, HTR2A, and, in males only, COMT.
|
26616111 |
2016 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
|
16642437 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
CTD_human |
SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.
|
18197083 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Similarly, three individuals (two with OCD/OCPD) carried the rare I425V SLC6A4 variant, but none of them passed it on to their six OCD-affected offspring, suggesting that it is unlikely to be solely responsible for the 'OCD plus syndrome', as reported by Ozaki et al.
|
19806148 |
2011 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since SSRIs act on the serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD.
|
11602033 |
2001 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Subgroups based on the age of OCD onset, gender, familiality, factor analysis-derived symptom dimensions, or comorbidity with other psychiatric disorders failed to identify SLC6A4- or BDNF-associated phenotypes, with one exception of overall number of comorbid anxiety disorders being significantly associated with 5-HTTLPR/rs25531.
|
17375136 |
2007 |