|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The SLC22A2 single nucleotide polymorphism (SNP) 808G/T was genotyped in 400 T2DM patients, including a metformin-treated group (n=200) and a non-metformin-treated group (n=200).
|
20139901 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms in the intergenic region between metformin transporter OCT2 and OCT3 coding genes are associated with short-term response to metformin monotherapy in type 2 diabetes mellitus patients.
|
27609360 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined the role of OCT2-T201M (602 C>T) variant in insulin resistance in patients with type 2 diabetes (T2D) who were treated with metformin.
|
25662675 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
As well as gender, the glucose-lowering efficiency of metformin can be enhanced by SLC22A2 808G > T variants through the delay of its transportation and CLr in Chinese type 2 diabetes populations.
|
25573751 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate whether genetic variations in the SLC22A1, SLC22A2, and SLC47A1 genes could be associated with an altered response to metformin in patients with type 2 diabetes mellitus.
|
31012983 |
2019 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We conclude that the expression pattern of OCT2, SSX2-4, and SAGE1 supports the origin of SS from spermatogonia and provides new evidence for heterogeneity of this tumour, potentially linked either to the cellular origin of SS or to partial differentiation during tumour progression, including a hitherto unknown OCT2-positive variant of the tumour likely derived from A(dark) spermatogonia.
|
21706474 |
2011 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We detected nominal evidence of association (P < 0.05) between the SLC22A2 (SNPs rs653753, rs596881, and rs316019) and SLC22A3 (SNPs rs376563, rs2048327, rs2457576, and rs1567438) genes and DN and hypertension in Finnish men with T1DM.
|
20429798 |
2010 |
|
Hypertensive disease
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We detected nominal evidence of association (P < 0.05) between the SLC22A2 (SNPs rs653753, rs596881, and rs316019) and SLC22A3 (SNPs rs376563, rs2048327, rs2457576, and rs1567438) genes and DN and hypertension in Finnish men with T1DM.
|
20429798 |
2010 |
|
Anxiety
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Anxiety Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Ataxia Telangiectasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, a polymorphism in intron 4 (rs3912161) and a haplotype (SLC22A2-ht3) showed significantly stronger association signals with the FEV(1) fall rate induced by aspirin provocation in AIA subjects compared with ATA controls (p = 0.004, P(corr) = 0.05).
|
21346370 |
2011 |
|
Diabetic Nephropathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We detected nominal evidence of association (P < 0.05) between the SLC22A2 (SNPs rs653753, rs596881, and rs316019) and SLC22A3 (SNPs rs376563, rs2048327, rs2457576, and rs1567438) genes and DN and hypertension in Finnish men with T1DM.
|
20429798 |
2010 |
|
Chronic pain
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Pharmacogenetics-based population pharmacokinetic analysis of gabapentin in patients with chronic pain: Effect of OCT2 and OCTN1 gene polymorphisms.
|
30192429 |
2019 |
|
Psychiatric symptom
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
SLC22A2 variants and dolutegravir levels correlate with psychiatric symptoms in persons with HIV.
|
30561642 |
2019 |
|
Malignant neoplasm of esophagus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, we examined 95 patients with oesophageal cancer who received 5-fluorouracil and cisplatin (FP) to determine whether nephrotoxicity was affected by SLC22A2 808G>T polymorphism.
|
24102360 |
2013 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we identified several genes associated with lymph node metastasis including Oct-2 or histological types including Liver-Intestine Cadherin.
|
11782383 |
2002 |
|
Psychoticism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
SLC22A2 CA genotype was independently associated with an abnormal GSI [adjusted OR (aOR) 2.43; P = 0.072], anxiety (aOR 2.61; P = 0.044), hostility (aOR 3.76; P = 0.012) and with moderate to severe headache (aOR 5.55; P = 0.037), and dolutegravir Ctrough was associated with hostility (fourth versus first quartile aOR 6.70; P = 0.007) and psychoticism (fourth versus first quartile aOR 19.01; P = 0.008).
|
30561642 |
2019 |
|
Hyperlactatemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The 808G>T variance in the SLC22A2 gene can affect the plasma lactate level and the incidence of hyperlactacidemia in T2DM patients undergoing metformin therapy.
|
20139901 |
2010 |
|
Behavioral and psychological symptoms of dementia
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
The effects of dolutegravir Ctrough and the SLC22A2 gene variant on NPs were explored by multivariable logistic regression.
|
30561642 |
2019 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Down-regulation of rat organic cation transporter rOCT2 by 5/6 nephrectomy.
|
12110012 |
2002 |
|
Kidney Failure, Chronic
|
0.300 |
Biomarker
|
disease |
RGD |
Protein and mRNA expression levels of Oat1, Oat 3, Oct1, and Oct2 were significantly decreased in adenine-induced CRF rats.
|
23280877 |
2013 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
CTD_human |
Similarly, OCT2 (∼2-fold) and OCT3 (∼3-fold) showed increased protein expression in the kidneys of obese patients compared with those of nonobese individuals.
|
27401566 |
2016 |
|
Hyperuricemia
|
0.210 |
Biomarker
|
disease |
BEFREE |
Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia.
|
30951542 |
2019 |
|
Hyperuricemia
|
0.210 |
Biomarker
|
disease |
RGD |
Restored expression and activity of organic ion transporters rOAT1, rOAT3 and rOCT2 after hyperuricemia in the rat kidney.
|
15748710 |
2005 |
|
Cholestasis, Extrahepatic
|
0.200 |
Biomarker
|
disease |
RGD |
Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2.
|
20814153 |
2010 |