|
Gastrointestinal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.
|
15709167 |
2005 |
|
leukemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Among primary tumours, methylation of BNIP3 was detected in five of 34 (15%) acute lymphocytic leukaemias, six of 35 (17%) acute myelogenous leukaemias and three of 14 (21%) multiple myelomas.
|
15756280 |
2005 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Apparently, epigenetic alteration of BNIP3 is a frequent and cancer-specific event, which suggests that inactivation of BNIP3 likely plays a key role in the progression of some gastrointestinal cancers and that it may be a useful molecular target for therapy.
|
15709167 |
2005 |
|
Necrotizing enterocolitis in fetus OR newborn
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, ileal samples obtained from infants undergoing surgical resection for acute NEC demonstrated higher levels of BNIP3 protein.
|
16002567 |
2005 |
|
Malignant neoplasm of stomach
|
0.310 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SDHB PCC are associated with a high risk of malignancy, and expression of (proapototic) BNIP3 was significantly lower in SDHB than VHL PCC.
|
16954163 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our objective was to compare protein (HIF-1alpha, EPAS1, SDHB, JunB, CCND1, CD34, CLU) and gene (VEGF, BNIP3) expression patterns in VHL and SDHB/D associated tumors.
|
16954163 |
2006 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SDHB PCC are associated with a high risk of malignancy, and expression of (proapototic) BNIP3 was significantly lower in SDHB than VHL PCC.
|
16954163 |
2006 |
|
Breast Carcinoma
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, a significant inverse correlation was observed in the expression of FAS and BNIP3 in clinical samples of human breast cancer.
|
16740734 |
2006 |
|
Malignant neoplasm of breast
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, a significant inverse correlation was observed in the expression of FAS and BNIP3 in clinical samples of human breast cancer.
|
16740734 |
2006 |
|
Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia.
|
16217754 |
2006 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
A broader expression analysis of RCC cell lines for BH3-only proteins revealed that loss of Nbk coincides with failure to express Bim, whereas Puma, Bid and BNIP3 are readily detectable and, in case of Puma, inducible by p53.
|
16322756 |
2006 |
|
Lung Neoplasms
|
0.020 |
Biomarker
|
group |
LHGDN |
Upregulation of BNIP3 promotes apoptosis of lung cancer cells that were induced by p53.
|
16765911 |
2006 |
|
Adrenal Gland Pheochromocytoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
SDHB PCC are associated with a high risk of malignancy, and expression of (proapototic) BNIP3 was significantly lower in SDHB than VHL PCC.
|
16954163 |
2006 |
|
Myocardial Reperfusion Injury
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy.
|
16645637 |
2007 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
RGD |
Pro-apoptotic Bcl2 family members, Bcl-2/adenovirus E1B 19 kDa interacting protein (BNIP3) and Bad levels, were significantly increased in obese rat hearts, whereas anti-apoptotic Bcl2 family member, Bcl2 level, was significantly decreased.
|
18070754 |
2007 |
|
Infarction, Middle Cerebral Artery
|
0.200 |
Biomarker
|
disease |
RGD |
BNIP3 upregulation and EndoG translocation in delayed neuronal death in stroke and in hypoxia.
|
17379825 |
2007 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast to the cancer cells, epithelial cells in normal gastric mucosa showed no or weak expression of BNIP3.
|
18092960 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Nuclear BNIP3 expression was also associated with a longer disease-free survival among low-grade and estrogen receptor-positive tumors.(P = 0.03 and 0.04, respectively).
|
17255267 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These studies identify BNIP3 as a key regulator of hypoxia-induced autophagy and suggest a novel role for the RB tumor suppressor in preventing nonapoptotic cell death by limiting the extent of BNIP3 induction in cells.
|
17576813 |
2007 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast to the cancer cells, epithelial cells in normal gastric mucosa showed no or weak expression of BNIP3.
|
18092960 |
2007 |
|
Breast Carcinoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
BNIP3 as a progression marker in primary human breast cancer; opposing functions in in situ versus invasive cancer.
|
17255267 |
2007 |
|
Breast Carcinoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In addition, we analyzed BNIP3 mutation in the DNA sequences encoding BH3 (Bcl-2 homology3) and TM (transmembrane) domains that are important in the cell death function of BNIP3 by single-strand conformation polymorphism (SSCP) in 48 colorectal, 48 gastric, and 48 breast carcinomas, and 48 acute leukemias.
|
18092960 |
2007 |