|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the transcription factor 7-like 2 gene (TCF7L2) represent the strongest and most reproducible genetic associations with diabetes.
|
24128935 |
2013 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In the DESIR cohort, a parental history of diabetes and the TCF7L2 at-risk variant were both associated with hypertension incidence at year 9, independently of waist circumference, BP, fasting glucose, insulin levels and HOMA-IR at inclusion (p = 0.02 for parental history, p = 0.006 for TCF7L2).
|
23942764 |
2013 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies have revealed that the T minor allele of single nucleotide polymorphism rs7903146 in the transcription factor 7-like 2 (TCF7L2) gene is strongly associated with an increased risk of diabetes by 30%-40%.
|
25058603 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Analysis of TCF7L2 rs7903146 in normal controls and diabetics with or without nephropathy demonstrated that the 'T' allele is associated with both diabetes (p = 0.049) and DN (p = 0.024), but this association is not independent of T2DM.
|
25185853 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Linagliptin significantly improved hyperglycaemia in patients with type 2 diabetes both with and without the TCF7L2 gene diabetes risk alleles.
|
24906949 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated.
|
24529562 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
T2D-related variants HHEX rs7923837, TCF7L2 rs290481 and CDKAL1 rs7756992 increased cancer risk in patients with diabetes.
|
24468095 |
2014 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that the TCF7L2 rs11196172 polymorphism increases the risk of CRC independently, with no evidence of an interaction with diabetes or obesity.
|
27792933 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, the TCF7L2 rs290487 TT genotype was associated with abdominal obesity and the GCG rs12104705 CC genotype was associated with both general obesity and abdominal obesity in case of new-onset diabetes.
|
27998387 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to investigate the possible association between diabetes susceptibility gene transcription factor 7-like 2 (TCF7L2) and gestational diabetes mellitus (GDM) in a Chinese Han population.
|
27465520 |
2016 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
TCF7L2 Genotype and α-Cell Function in Humans Without Diabetes.
|
26525881 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
TCF7L2 is a transcription factor in the canonical Wnt pathway, involved in multiple disorders, including diabetes, cancer and psychiatric conditions.
|
26934194 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.
|
26914832 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Role of TCF7L2 rs7903146 in Diabetes After Kidney Transplant: Results From a Single-Center Cohort and Meta-Analysis of the Literature.
|
26555947 |
2016 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
An interaction (p = 0.048) between TCF7L2 variants and coffee intake was apparent, with an inverse association between coffee and type 2 diabetes present among carriers of the diabetes risk allele (T) in rs12255372 (GG: HR 0.99 [95% CI 0.97, 1.02] per cup of coffee; GT: HR 0.96 [95% CI 0.93, 0.98]); and TT: HR 0.93 [95% CI 0.88, 0.98]).
|
27623947 |
2016 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
The Tcf7l2 gene encodes a key Wnt signalling pathway effector, and its human homologue TCF7L2 is a highly regarded diabetes risk gene.
|
28102847 |
2017 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
TCF7L2 rs7903146 C>T polymorphism is associated with diabetes in the general population but its independent impact on cardiovascular disease is debated.
|
28299838 |
2017 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for known confounding factors, we found a significant association between TCF7L2/rs122555372 and C-peptide (β = -0.76, P = .005) in patients with diabetes and between fasting glucose (β = 2.05, P = .039) and homeostatic model assessment of β-cell function (β = -32.14, P = .025) levels in individuals without diabetes.
|
28101933 |
2017 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
In this study, we discovered a previously unrecognized role for Tcf7l2, a transcription factor known as the canonical Wnt nuclear effector and diabetes risk-conferring gene, in establishing neuronal identity and circuits of the caudal forebrain.
|
28219675 |
2017 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to explore the correlation between rs7903146 and rs290487 polymorphisms in transcription factor 7-like 2 (TCF7L2) gene and diabetic nephropathy (DN) in Chinese Han population.Polymerase chain reaction-restriction fragment length polymorphism was used to determine genotypes of TCF7L2 polymorphisms in 90 patients with DN and 96 diabetes patients without DN.
|
30290587 |
2018 |
|
Diabetes
|
0.200 |
Biomarker
|
disease |
BEFREE |
However, the mechanism(s) by which TCF7L2 predisposes to diabetes remain uncertain.
|
29993315 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits.
|
30419301 |
2018 |
|
Diabetes
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Our findings thus propose a potential cellular mechanism through which abnormal TCF7L2 activity predisposes individuals to diabetes and implicates abnormalities in the islet microenvironment in this disease.
|
29246974 |
2018 |
|
Diabetes
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Transcription factor 7-like 2 (TCF7L2), which previously known as TCF-4, is a major form of transcription factor involved in the downstream WNT signaling and exhibits the strongest association to diabetes susceptibility.
|
31312258 |
2019 |