|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Molecular characterization of a t(7;19)(q34;p13) in a pediatric T-cell acute lymphoblastic leukemia patient led to the identification of a translocation between the TRB@ and LYL1 loci.
|
22058201 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), activating mutations of NOTCH1 are observed in more than 50% of cases, whereas the t(7;9)(q34;q34) involving NOTCH1 at 9q34 and TRB@ at 7q34 is an extremely rare but recurrent translocation.
|
23033986 |
2013 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus.
|
15774621 |
2005 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar.
|
9409647 |
1997 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Ten TCRB allelic polymorphisms were analyzed from 3 groups of white women: 112 with RA, 72 with systemic lupus erythematosus, and 70 healthy controls.All participants were also HLA typed.
|
8651986 |
1996 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results argue against the hypothesis that TCRB polymorphisms play a crucial role in the susceptibility for RA.
|
7979596 |
1994 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
LHGDN |
Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements.
|
12594835 |
2003 |
|
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
|
9336413 |
1997 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls.
|
1982251 |
1991 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM.
|
10075863 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas.
|
8909943 |
1996 |
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families.
|
3467587 |
1986 |
|
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2.1-3.1.
|
3467586 |
1986 |
|
Leukemia, T-Cell
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
|
Leukemia, T-Cell
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In an attempt to more accurately define cell lineage we have analyzed cells from patients with B- or T-cell leukemia (n = 26) at various stages of maturation with probes to two additional TCR genes, TCRG and TCRA (encoding the TCR gamma and alpha chains, respectively), as well as the IG heavy chain joining region (IGHJ) and TCRB genes.
|
3464980 |
1986 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.
|
3025859 |
1987 |
|
Sezary Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
|
Sezary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS.
|
21410672 |
2011 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
We analyzed TCR gene loci (TCRAD, TCRB, and TCRG) status in CTCLs by fluorescence in situ hybridization (FISH).
|
21872828 |
2011 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
LHGDN |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
BEFREE |
The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica antigen isolated from synovial fluids of 3 HLA-B27+ patients with ReA and PBL of one healthy HLA-B27+ individual.
|
8560188 |
1996 |
|
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
LHGDN |
All but one patient-derived conserved sequences originated from acute stage ReA-patients, and were not present among approximately 3800 other human TCRB sequences in the database.
|
12472659 |
2002 |