TRB, T cell receptor beta locus, 6957

N. diseases: 49; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1961099
Disease: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 		0.330 FusionGene disease ORPHANET
CUI: C2936781
Disease: Generalized Myotonia of Thomsen
Generalized Myotonia of Thomsen 		0.010 GeneticVariation disease BEFREE Linkage analysis of Thomsen disease to the T-cell-receptor beta (TCRB) locus at 7q35 was carried out in four pedigrees (25 affected and 23 unaffected individuals) by using a PCR-based dinucleotide repeat polymorphism in the TCRB gene. 1386711 1992
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.030 Biomarker disease BEFREE Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls. 1982251 1991
CUI: C0023493
Disease: Adult T-Cell Lymphoma/Leukemia
Adult T-Cell Lymphoma/Leukemia 		0.020 Biomarker disease BEFREE Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia. 3025859 1987
CUI: C0023418
Disease: leukemia
leukemia 		0.010 Biomarker disease BEFREE Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL. 3025859 1987
CUI: C1332977
Disease: Childhood Leukemia
Childhood Leukemia 		0.010 Biomarker disease BEFREE Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL. 3025859 1987
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.020 GeneticVariation disease BEFREE In an attempt to more accurately define cell lineage we have analyzed cells from patients with B- or T-cell leukemia (n = 26) at various stages of maturation with probes to two additional TCR genes, TCRG and TCRA (encoding the TCR gamma and alpha chains, respectively), as well as the IG heavy chain joining region (IGHJ) and TCRB genes. 3464980 1986
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.020 GeneticVariation disease BEFREE The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2.1-3.1. 3467586 1986
CUI: C0010674
Disease: Cystic Fibrosis
Cystic Fibrosis 		0.020 Biomarker disease BEFREE Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families. 3467587 1986
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE The T-cell receptor beta locus and susceptibility to multiple sclerosis. 7477982 1995
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.050 GeneticVariation disease BEFREE These results argue against the hypothesis that TCRB polymorphisms play a crucial role in the susceptibility for RA. 7979596 1994
CUI: C0085435
Disease: Arthritis, Reactive
Arthritis, Reactive 		0.020 Biomarker disease BEFREE The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica antigen isolated from synovial fluids of 3 HLA-B27+ patients with ReA and PBL of one healthy HLA-B27+ individual. 8560188 1996
CUI: C0079774
Disease: Peripheral T-Cell Lymphoma
Peripheral T-Cell Lymphoma 		0.010 AlteredExpression disease BEFREE The lack of CD3 and TCRAB membrane expression on otherwise phenotypically normal mature T lymphocytes together with the absence of detectable TCRBV mRNA and clonal rearrangement of TCRB gene suggested that the abnormal lymphocyte population was the expression of a peripheral T-cell lymphoma with an indolent clinical course. 8608231 1996
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.050 GeneticVariation disease BEFREE Ten TCRB allelic polymorphisms were analyzed from 3 groups of white women: 112 with RA, 72 with systemic lupus erythematosus, and 70 healthy controls.All participants were also HLA typed. 8651986 1996
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.030 GeneticVariation disease BEFREE A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas. 8909943 1996
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.050 GeneticVariation disease BEFREE These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA. 9336413 1997
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.020 GeneticVariation group BEFREE Genotypic analysis showed that the tumors were B-lineage and clonal, with rearrangements of the Ig heavy- and kappa light-chain loci and no rearrangements of the T-cell receptor beta locus. 9376569 1997
CUI: C0031090
Disease: Periodontal Diseases
Periodontal Diseases 		0.010 AlteredExpression group BEFREE PCR products from both the PBL and periodontal tissue of CAPD patients were cloned and sequenced; analysis of the nucleotide sequence revealed diversity with respect to the expression of TCRB joining (TCRBJ) and TCRB diversity (TCRBD) genes and the sequence of the junctional region in all samples analysed. 9395100 1997
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.050 GeneticVariation disease BEFREE Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar. 9409647 1997
CUI: C0026948
Disease: Mycosis Fungoides
Mycosis Fungoides 		0.050 Biomarker group BEFREE Lymph node TCRB gene analysis provides additional prognostic information for patients with mycosis fungoides with intermediate LN histopathology. 9487207 1998
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.010 GeneticVariation disease BEFREE It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. 9619899 1998
CUI: C0017574
Disease: Gingivitis
Gingivitis 		0.010 AlteredExpression disease BEFREE Longitudinal changes in TCRB variable gene expression and markers of gingival inflammation in experimental gingivitis. 9797048 1998
CUI: C1292769
Disease: Precursor B-cell lymphoblastic leukemia
Precursor B-cell lymphoblastic leukemia 		0.010 Biomarker disease BEFREE A large series of 202 childhood precursor-B cell acute lymphoblastic leukemia (ALL) patients was analyzed by Southern blotting (SB) for cross-lineage rearrangements and/or deletions in the T cell receptor TCRB, TCRG and TCRD loci. 10025893 1999
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.030 AlteredExpression disease BEFREE These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM. 10075863 1999
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.060 Biomarker group BEFREE TCRB gene rearrangement patterns differed between the various categories of T cell malignancies. 10360387 1999