|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
TCRB gene rearrangement patterns differed between the various categories of T cell malignancies.
|
10360387 |
1999 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas.
|
8909943 |
1996 |
|
Precursor B-cell lymphoblastic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
A large series of 202 childhood precursor-B cell acute lymphoblastic leukemia (ALL) patients was analyzed by Southern blotting (SB) for cross-lineage rearrangements and/or deletions in the T cell receptor TCRB, TCRG and TCRD loci.
|
10025893 |
1999 |
|
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
LHGDN |
All but one patient-derived conserved sequences originated from acute stage ReA-patients, and were not present among approximately 3800 other human TCRB sequences in the database.
|
12472659 |
2002 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
LHGDN |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Neoplasm, Residual
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
As expected, HTS of TCRB and TCRG identified MRD that was not detected by flow cytometry in a subset of cases (25 of 35 HTS compared with 13 of 35, respectively), which highlights the potential of this technology to define lower detection thresholds for MRD that could affect clinical treatment decisions.
|
22593176 |
2012 |
|
Mixed Connective Tissue Disease
|
0.010 |
Biomarker
|
disease |
LHGDN |
CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease.
|
18523312 |
2008 |
|
Eosinophilic granulomatosis with polyangiitis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome.
|
18502180 |
2008 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma.
|
20423568 |
2010 |
|
Adult Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Clonal expanded TRA and TRB subfamily T cells in peripheral blood from patients with diffuse large B-cell lymphoma.
|
20423568 |
2010 |
|
Rheumatoid Arthritis
|
0.050 |
Biomarker
|
disease |
LHGDN |
Clonally expanded CD4+CD28null T cells in rheumatoid arthritis use distinct combinations of T cell receptor BV and BJ elements.
|
12594835 |
2003 |
|
Dermatologic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Combined use of PCR-based TCRG and TCRB clonality tests on paraffin-embedded skin tissue in the differential diagnosis of mycosis fungoides and inflammatory dermatoses.
|
20203005 |
2010 |
|
Malignant Neoplasms
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Dominant Variable (V) and Joining (J) gene pair rearrangements in cancer cells were confirmed by polymerase chain reaction (PCR) amplification and Sanger sequencing; clonality assessment of clinical isolates using BIOMED-2 methods showed agreement for 73% and 77% of samples at the β and γ loci, respectively, whereas β locus V and J allele prevalence in PBMCs were well correlated with results from commercial PCR-based DNA sequencing assays (<i>r</i><sup>2</sup> = 0.94 with Adaptive ImmunoSEQ, 0.77-0.83 with Invivoscribe LymphoTrack TRB Assay).
|
30530777 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Dominant Variable (V) and Joining (J) gene pair rearrangements in cancer cells were confirmed by polymerase chain reaction (PCR) amplification and Sanger sequencing; clonality assessment of clinical isolates using BIOMED-2 methods showed agreement for 73% and 77% of samples at the β and γ loci, respectively, whereas β locus V and J allele prevalence in PBMCs were well correlated with results from commercial PCR-based DNA sequencing assays (<i>r</i><sup>2</sup> = 0.94 with Adaptive ImmunoSEQ, 0.77-0.83 with Invivoscribe LymphoTrack TRB Assay).
|
30530777 |
2018 |
|
Mycosis Fungoides
|
0.050 |
GeneticVariation
|
group |
BEFREE |
Gains of TCRB and TCRG genes were observed in 23% (3 of 13) of SS and 50% (3 of 6) of MFt, reflecting the presence of trisomy and/or tetrasomy of chromosome 7 already detected by conventional cytogenetics and array comparative genetic hybridization techniques.
|
21872828 |
2011 |
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families.
|
3467587 |
1986 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genotypic analysis showed that the tumors were B-lineage and clonal, with rearrangements of the Ig heavy- and kappa light-chain loci and no rearrangements of the T-cell receptor beta locus.
|
9376569 |
1997 |
|
Generalized Thyroid Hormone Resistance
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we describe in a patient with RTH, a new mutation in codon 426 (T426I) of the TRb gene leading to a threonine to isoleucine substitution.
|
10660344 |
1998 |
|
Ataxia Telangiectasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
High frequencies of TRGV-BJ hybrid gene (rearrangement between the TRB and TRG loci at 7q35 and 7p14-15, respectively) have been detected in lymphocytes from patients with ataxia telangiectasia (AT), and also in patients with lymphoid malignancies.
|
19142737 |
2009 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
High frequencies of TRGV-BJ hybrid gene (rearrangement between the TRB and TRG loci at 7q35 and 7p14-15, respectively) have been detected in lymphocytes from patients with ataxia telangiectasia (AT), and also in patients with lymphoid malignancies.
|
19142737 |
2009 |
|
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
However, because T-cell malignancies contain identically rearranged T-cell receptor gamma (TCRG) and/or beta (TCRB) genes, the polymerase chain reaction (PCR) can be a fast, convenient, and dependable option to identify clonal T-cell processes.
|
23666697 |
2013 |
|
Hypothyroidism
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
If maternal antibody-mediated hypothyroidism is suspected, measurement of maternal and/or neonatal TRB-Ab will confirm the diagnosis.
|
10447022 |
1999 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), activating mutations of NOTCH1 are observed in more than 50% of cases, whereas the t(7;9)(q34;q34) involving NOTCH1 at 9q34 and TRB@ at 7q34 is an extremely rare but recurrent translocation.
|
23033986 |
2013 |