Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.330 |
FusionGene
|
disease |
ORPHANET |
|
|
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families.
|
3467587 |
1986 |
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2.1-3.1.
|
3467586 |
1986 |
Leukemia, T-Cell
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In an attempt to more accurately define cell lineage we have analyzed cells from patients with B- or T-cell leukemia (n = 26) at various stages of maturation with probes to two additional TCR genes, TCRG and TCRA (encoding the TCR gamma and alpha chains, respectively), as well as the IG heavy chain joining region (IGHJ) and TCRB genes.
|
3464980 |
1986 |
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.
|
3025859 |
1987 |
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL.
|
3025859 |
1987 |
Childhood Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our cytogenetic analysis of one such cell line, SUP-T3, demonstrates that the breakpoints on chromosomes 7 and 9 lie within bands q36 and q34, respectively, corresponding to the location of the gene encoding the beta chain of the T-cell receptor, TCRB, and the gene homologous to the transforming gene of the Abelson murine leukemia virus, ABL.
|
3025859 |
1987 |
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls.
|
1982251 |
1991 |
Generalized Myotonia of Thomsen
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Linkage analysis of Thomsen disease to the T-cell-receptor beta (TCRB) locus at 7q35 was carried out in four pedigrees (25 affected and 23 unaffected individuals) by using a PCR-based dinucleotide repeat polymorphism in the TCRB gene.
|
1386711 |
1992 |
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These results argue against the hypothesis that TCRB polymorphisms play a crucial role in the susceptibility for RA.
|
7979596 |
1994 |
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The T-cell receptor beta locus and susceptibility to multiple sclerosis.
|
7477982 |
1995 |
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Ten TCRB allelic polymorphisms were analyzed from 3 groups of white women: 112 with RA, 72 with systemic lupus erythematosus, and 70 healthy controls.All participants were also HLA typed.
|
8651986 |
1996 |
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A highly polymorphic microsatellite marker mapping to the TCRBV6.7 gene and a TCRB C-region RFLP were used to genotype the members of a total of 21 multiplex IDDM families from two different geographical areas.
|
8909943 |
1996 |
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
BEFREE |
The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica antigen isolated from synovial fluids of 3 HLA-B27+ patients with ReA and PBL of one healthy HLA-B27+ individual.
|
8560188 |
1996 |
Peripheral T-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The lack of CD3 and TCRAB membrane expression on otherwise phenotypically normal mature T lymphocytes together with the absence of detectable TCRBV mRNA and clonal rearrangement of TCRB gene suggested that the abnormal lymphocyte population was the expression of a peripheral T-cell lymphoma with an indolent clinical course.
|
8608231 |
1996 |
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
Our previous studies have disclosed that the peripheral T cell receptor beta (TCRB) gene repertoires of RA monozygotic twins were similar.
|
9409647 |
1997 |
Rheumatoid Arthritis
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
|
9336413 |
1997 |
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genotypic analysis showed that the tumors were B-lineage and clonal, with rearrangements of the Ig heavy- and kappa light-chain loci and no rearrangements of the T-cell receptor beta locus.
|
9376569 |
1997 |
Periodontal Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PCR products from both the PBL and periodontal tissue of CAPD patients were cloned and sequenced; analysis of the nucleotide sequence revealed diversity with respect to the expression of TCRB joining (TCRBJ) and TCRB diversity (TCRBD) genes and the sequence of the junctional region in all samples analysed.
|
9395100 |
1997 |
Mycosis Fungoides
|
0.050 |
Biomarker
|
group |
BEFREE |
Lymph node TCRB gene analysis provides additional prognostic information for patients with mycosis fungoides with intermediate LN histopathology.
|
9487207 |
1998 |
Gingivitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Longitudinal changes in TCRB variable gene expression and markers of gingival inflammation in experimental gingivitis.
|
9797048 |
1998 |
Ankylosing spondylitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis.
|
9619899 |
1998 |
Generalized Thyroid Hormone Resistance
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here we describe in a patient with RTH, a new mutation in codon 426 (T426I) of the TRb gene leading to a threonine to isoleucine substitution.
|
10660344 |
1998 |
Malignant Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
TCRB gene rearrangement patterns differed between the various categories of T cell malignancies.
|
10360387 |
1999 |
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
These data support restricted TCRB gene usage in T cell populations enriched for in vivo activated clones in patients with IDDM.
|
10075863 |
1999 |