|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension.
|
30276527 |
2019 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
TLR4 D299 G showed an inverse association with pulmonary hypertension.
|
25182168 |
2015 |
|
Hypertensive disease
|
0.400 |
Biomarker
|
group |
BEFREE |
HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling.
|
30610955 |
2019 |
|
Colorectal Neoplasms
|
0.340 |
AlteredExpression
|
group |
LHGDN |
Reduced expression of TLR4 is associated with the metastatic status of human colorectal cancer.
|
17549384 |
2007 |
|
Colorectal Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer.
|
16879199 |
2006 |
|
Colorectal Neoplasms
|
0.340 |
AlteredExpression
|
group |
LHGDN |
[Expression of toll-like receptor 4 in colorectal cancer].
|
19106585 |
2008 |
|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
Microsatelite GT polymorphism in the toll-like receptor 2 is associated with colorectal cancer.
|
16879199 |
2006 |
|
Colorectal Neoplasms
|
0.340 |
GeneticVariation
|
group |
LHGDN |
Polymorphism of CD14 gene but not the mutation of TLR4 gene is associated with colorectal cancer in Chinese patients.
|
16706818 |
2006 |
|
Colorectal Neoplasms
|
0.340 |
Biomarker
|
group |
CTD_human |
Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma.
|
22180778 |
2011 |
|
Carcinoma
|
0.320 |
AlteredExpression
|
group |
BEFREE |
However, recent studies have shown that TLR4 is aberrantly expressed in various types of carcinomas and may correlate with tumor progression.
|
21152870 |
2011 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
CTD_human |
Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma.
|
22180778 |
2011 |
|
Carcinoma
|
0.320 |
AlteredExpression
|
group |
BEFREE |
TLR4 expression was present in all ovarian epithelium (normal and neoplastic), whereas MyD88 was restricted to neoplastic cells, independent of tumour grade and associated with reduced progression-free and overall survival, in an immunohistological specific subset of serous carcinomas, p<0.05.
|
24977712 |
2014 |
|
Prostatic Neoplasms
|
0.320 |
GeneticVariation
|
group |
LHGDN |
Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer.
|
16357190 |
2005 |
|
Prostatic Neoplasms
|
0.320 |
AlteredExpression
|
group |
LHGDN |
TLR4 signaling promotes the expression of VEGF and TGFbeta1 in human prostate epithelial PC3 cells induced by lipopolysaccharide.
|
18649875 |
2008 |
|
Prostatic Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Toll-like receptor 4 genetic variation and advanced prostate cancer risk.
|
17301271 |
2007 |
|
Lung Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
TLR4 signaling promotes immune escape of human lung cancer cells by inducing immunosuppressive cytokines and apoptosis resistance.
|
17328955 |
2007 |
|
Lung Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis.
|
19925653 |
2009 |
|
Learning Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol.
|
29107071 |
2017 |
|
Diabetic Polyneuropathies
|
0.300 |
Biomarker
|
group |
CTD_human |
Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with a reduced prevalence of diabetic neuropathy in patients with type 2 diabetes.
|
14693986 |
2004 |
|
Adult Learning Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Role of TLR4 in olfactory-based spatial learning activity of neonatal mice after developmental exposure to diesel exhaust origin secondary organic aerosol.
|
29107071 |
2017 |
|
Lung diseases
|
0.240 |
Biomarker
|
group |
RGD |
Effect of nitric oxide on toll-like receptor 2 and 4 gene expression in rats with acute lung injury complicated by acute hemorrhage necrotizing pancreatitis.
|
16286274 |
2005 |
|
Lung diseases
|
0.240 |
Biomarker
|
group |
BEFREE |
Nicotinamide phosphoribosyltransferase (NAMPT) exists as both intracellular NAMPT and extracellular NAMPT (eNAMPT) proteins. eNAMPT is secreted into the blood and functions as a cytokine/enzyme (cytozyme) that activates NF-κB signaling via ligation of Toll-like receptor 4 (TLR4), further serving as a biomarker for inflammatory lung disorders such as acute respiratory distress syndrome.
|
29337590 |
2018 |
|
Lung diseases
|
0.240 |
Biomarker
|
group |
RGD |
[The role of expression of Toll-like receptor 2 and Toll-like receptor 4 in hyperoxia-induced acute lung injury in rat].
|
19930876 |
2009 |
|
Lung diseases
|
0.240 |
Biomarker
|
group |
BEFREE |
The results of the present study showed that administration of PA worsened the pathophysiology of PA lung disease in TLR4 and PPARα KO mice compared with WT mice.
|
29547450 |
2019 |
|
Lung diseases
|
0.240 |
Biomarker
|
group |
BEFREE |
Tracheobronchial epithelial cells (TBEC) and AMs from four smokers and four non-smokers without lung disease were cultured with or without Poly(I:C) (PIC) (a TLR3 agonist) or LPS (a TLR4 agonist) for 4, 24 and 48 h. The immune responses of paired cells were compared.
|
29940963 |
2018 |