Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
<i>Sch B</i> could protect against LPS-induced sepsis via the TLR4/NF-κB/MyD88 signaling pathway, and potentially be a novel anti-inflammatory and immunosuppressive drug candidate for treating sepsis.
|
29736208 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
|
29545858 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell death by pyroptosis and is deeply implicated in the development of sepsis.
|
29780528 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Bacterial lipopolysaccharide (LPS), mainly functioning by stimulating toll-like receptor 4 (TLR4), mediates platelet activation and sepsis.
|
29653689 |
2018 |
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To simulate sepsis, male C57BL/6 (wild-type) and C57BL/10ScNJNJU (TLR4<sup>-/-</sup>) mice were subjected to cecal ligation and puncture (CLP).
|
29149705 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicate that CIRP is a proinflammatory mediator that plays an important role in T-cell dysregulation during sepsis in a TLR4-dependent manner.
|
27569563 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, the role of deleted in liver cancer 1 (DILC), interleukin (IL)‑6, signal transducer and activator of transcription 3 (STAT3), and Toll‑like receptor 4 (TLR4) in the pathogenesis of sepsis was investigated.
|
30365067 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, the present results suggested that apelin had a protective effect against sepsis‑induced cardiac impairment by attenuating TLR4 and NLRP3 signaling‑mediated inflammatory responses.
|
29749463 |
2018 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The activation of the TLR4/TLR9/p38 MAPK/STAT3 signal pathway contributes to the production of miR-23b in CLP-induced sepsis. miR-23b inhibitor decreased the number of spleen cells positive by terminal deoxynucleotidyl transferase dUTP nick-end labeling and improved survival. miR-23b inhibitor restored the immunoreactivity by alleviating the development of T-cell exhaustion and producing smaller amounts of immunosuppressive interleukin 10 and interleukin 4 during late sepsis.
|
29506272 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data show for the first time that otherwise noninjurious mechanical ventilation can exacerbate ALI due to extrapulmonary sepsis underscoring a potential interactive contribution of common events (sepsis and mechanical ventilation) in critical care, and that a WISP1-TLR4-integrin β5 pathway contributes to this phenomenon.
|
30445996 |
2018 |
Necrotizing Enterocolitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
|
28846670 |
2018 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Myeloid differentiation 2 (MD2) is essential to the recognition of lipopolysaccharide (LPS) and the subsequent mediation of toll-like receptor 4 (TLR4)-dependent acute inflammatory disorders including sepsis and acute lung injury.
|
28858767 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis.
|
28976923 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of the present work was to delineate the beneficial role of BZL during sepsis, analyzing its effects on the cellular redox status and the possible link to the innate immunity receptor TLR4.
|
27899278 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, early-onset sepsis in term babies is caused by gram-positive species in more than 90% of cases, and neuro-inflammatory responses triggered through the gram-negative route (Toll-like receptor 4, TLR-4) are different from those induced through the gram-positive route via TLR-2.
|
28407632 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The definition of the structural determinants of the LPS transfer cascade to TLR4 may enable the development of targeted therapeutics for intervention in LPS-induced sepsis.
|
27986454 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies found toll-like receptors 4 (TLR4) played an important role in sepsis.
|
28056977 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
ULI administration may improve patient outcome by reducing the spinal inflammation through a mechanism involving the TLR4/MyD88/NF-κB signaling in sepsis.
|
28796387 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, GLN has a potential therapeutic effect in the protection against cardiac dysfunction mediated by sepsis through regulating the TLR4/MAPK/NF-κB signaling pathway.
|
29285127 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because TcpB suppresses both TLR4- and caspase-4/11-mediated inflammation, TcpB might be a candidate target for developing drugs against LPS-induced septicemia.
|
29061850 |
2017 |
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, preemptive clinical sedative doses of DXM may upregulate the expression of caveolin‑1 downregulated by sepsis, which may contribute to the inhibition of inflammatory pathways such as TLR4‑mediated pathways.
|
28000867 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248930 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Acute hepatic dysfunction associating sepsis is mediated mainly by toll-like receptor-4 (TLR-4)/nuclear factor kappa-B (NF-κB) inflammatory pathway.
|
28189063 |
2017 |
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to assess the role played by TLR4 and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after high-grade polymicrobial sepsis.
|
29176403 |
2017 |