|
Sepsis
|
0.600 |
Biomarker
|
disease |
RGD |
[Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats].
|
19489280 |
2009 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts.
|
20525286 |
2010 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Monophosphoryl lipid A (MPLA) is a detoxified TLR4 agonist that enhances innate antimicrobial immunity and improves survival following sepsis.
|
29741098 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Activation of the TLR4 receptor by bacterial lipopolysaccharide (LPS) is the most widely studied TLR pathway due to its central role in host responses to gram-negative bacterial infection and its contribution to endotoxemia and sepsis.
|
28248925 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, early-onset sepsis in term babies is caused by gram-positive species in more than 90% of cases, and neuro-inflammatory responses triggered through the gram-negative route (Toll-like receptor 4, TLR-4) are different from those induced through the gram-positive route via TLR-2.
|
28407632 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HES could ameliorate BBB dysfunction and inflammation mediators by modulating brain TLR2 and TLR4 expression during sepsis.
|
20451670 |
2010 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the response to a TLR2 ligand is muted in cohoused mice, whereas the response to a TLR4 ligand is greatly amplified, suggesting a basis for the distinct response to Listeria monocytogenes and sepsis.
|
31412243 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The definition of the structural determinants of the LPS transfer cascade to TLR4 may enable the development of targeted therapeutics for intervention in LPS-induced sepsis.
|
27986454 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
RGD |
[Changes in Toll-like receptor 2 and 4 gene expression in vital organs in septic rats and their regulation mechanisms].
|
14604479 |
2003 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
To validate the concept of TLR4-targeted treatment strategies in gram-negative sepsis, we first showed that TLR4(-/-) and myeloid differentiation primary response gene 88 (MyD88)(-/-) mice were fully resistant to Escherichia coli-induced septic shock, whereas TLR2(-/-) and wild-type mice rapidly died of fulminant sepsis.
|
19181857 |
2009 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
<i>Sch B</i> could protect against LPS-induced sepsis via the TLR4/NF-κB/MyD88 signaling pathway, and potentially be a novel anti-inflammatory and immunosuppressive drug candidate for treating sepsis.
|
29736208 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effect of TLR4/MyD88 signaling pathway on sepsis-associated acute respiratory distress syndrome in rats, via regulation of macrophage activation and inflammatory response.
|
29545858 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Highlights of this study include: human SAA is possibly only expressed in a subset of septic patients; SAA induces HMGB1 release via TLR4 and RAGE receptors; SAA supplementation worsens the outcome of lethal endotoxemia; whereas SAA-neutralizing antibodies confer protection against lethal endotoxemia and sepsis.
|
26052716 |
2015 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results further indicate that Toll-1 and Toll-7 bind multiple Spz proteins and also VSV, but they differentially affect adult survival after systemic infection, potentially because of sex-specific differences in Toll-1 and Toll-7 expression.
|
31088910 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent studies found toll-like receptors 4 (TLR4) played an important role in sepsis.
|
28056977 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gram-negative bacterial lipopolysaccharide (LPS)-induced Toll-like receptor 4 (TLR4) mediated pro-inflammatory signaling plays a key role in immunoprotection against infectious challenges and boosts adaptive immunity, whereas the activation of the cytosolic LPS receptor caspase-4/11 leads to cell death by pyroptosis and is deeply implicated in the development of sepsis.
|
29780528 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the effect of dexmedetomidine (DEX) on kidney injury in sepsis rats through the Toll-like receptor 4 (TLR4)/myeloid differential protein-88 (MyD88)/nuclear factor-κB (NF-κB)/inducible nitric oxide synthase (iNOS) signaling pathway.
|
31210339 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
ULI administration may improve patient outcome by reducing the spinal inflammation through a mechanism involving the TLR4/MyD88/NF-κB signaling in sepsis.
|
28796387 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-<i>γ</i> Expression in CD38<sup>-/-</sup> Mice.
|
30915370 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Some TLR4 modulators are undergoing preclinical and clinical evaluation for the treatment of sepsis, inflammatory diseases, cancer, and rheumatoid arthritis.
|
25515751 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of α7nAChR, toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), and cleaved caspase-3 increased, peaking 24 h during sepsis.
|
31520992 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo, ES-62 protected mice against endotoxic and polymicrobial septic shock by TLR4-mediated induction of autophagy and was protective even when administered after the induction of sepsis.
|
21358639 |
2011 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, GLN has a potential therapeutic effect in the protection against cardiac dysfunction mediated by sepsis through regulating the TLR4/MAPK/NF-κB signaling pathway.
|
29285127 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Increasing evidence indicates that Toll-like receptor 4 (TLR4) plays a key role in the development of sepsis.
|
30940475 |
2019 |
|
Sepsis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections.
|
20375592 |
2009 |