|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Animal models of oxygen-induced retinopathy studies have shown vascular endothelial growth factor (VEGF) to be a key player in the pathogenesis of ROP.
|
27388246 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Relationship Between Visual Acuity and Retinal Thickness During Anti-Vascular Endothelial Growth Factor Therapy for Retinal Diseases.
|
28549848 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
We further show that prototype long-acting anti-VEGF drugs (LAVAs) that include this peptide attenuate VEGF-induced retinal changes in animal models of neovascular retinal disease ∼3-4-fold longer than unmodified drugs.
|
28332616 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Adrenomedullin Suppresses Vascular Endothelial Growth Factor-Induced Vascular Hyperpermeability and Inflammation in Retinopathy.
|
28322199 |
2017 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We postulate that exogenous insulin could act synergistically with the vascular endothelial growth factor expressed by ischemic retina so as to trigger vascular proliferation and the worsening of diabetes retinopathy.
|
29017477 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
At 12 weeks after fenofibrate treatment, serum IL-1β, TNF-α, VEGF, and Lp-PLA2 levels were detected.In PDR and NPDR patients, levels of serum cytokines such as IL-1β (120.56 ± 27.32 pg/mL vs 112.34 ± 19.45 pg/mL vs 82.9 ± 13.8 pg/mL), TNF-α (125.86 ± 25.57 pg/mL vs 109.48 ± 20.15 pg/mL vs 80.7 ± 12.8 pg/mL), VEGF (166.65 ± 37.74 pg/mL vs 148.54 ± 36.27 pg/mL vs 88.97 ± 24.86 pg/mL), and Lp-PLA2 (172.34 ± 45.22 μg/L vs 154.66 ± 40.98 μg/L vs 125.88 ± 38.87 μg/L) were significantly higher than in diabetes patients without retinopathy.
|
28767589 |
2017 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Retinal VEGF levels correlate with ocular circulation measured by a laser speckle-micro system in an oxygen-induced retinopathy rat model.
|
28791491 |
2017 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The vascular endothelial growth factor (VEGF) +405 (C/G) and -460 (T/C) polymorphisms are associated with retinopathy and possibly with nephropathy, however no information is available on their relationship with peripheral neuropathy.
|
28662688 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations indicated that the Wnt pathway/COX-2/VEGF axis plays a pathogenic role in retinopathy and represented novel therapeutic targets.
|
29158916 |
2017 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The levels of VEGF were similar in patients with T1D and microvascular complications (microalbuminuria and retinopathy) when compared with patients without microvascular complications.
|
28421206 |
2017 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Changes in Retinal Nerve Fiber Layer Thickness after Multiple Injections of Novel VEGF Decoy Receptor Conbercept for Various Retinal Diseases.
|
27922068 |
2016 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Significantly elevated levels of serum VEGF and highest VEGF expression were found among PDR subjects compared to DNR or NPDR subjects.
|
25956512 |
2015 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis and thus contributes to many vasoproliferative retinopathies including retinopathy of prematurity.
|
25605522 |
2015 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy.
|
25866826 |
2015 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis of association between the -2578C/A polymorphism of the vascular endothelial growth factor and retinopathy in type 2 diabetes in Asians and Caucasians.
|
24751925 |
2014 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
However, until now only a handful number of genetic variants were reported to be associated with either nephropathy (ACE, ELMO1, FRMD3, and AKR1B1) or retinopathy (VEGF, AKR1B1, and EPO), and only a few studies were carried out for genetic susceptibility to cardiovascular diseases (ADIPOQ, GLUL) in patients with diabetes.
|
25169573 |
2014 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of VEGF has been identified to be associated with many pathologic processes such as tumors and retinopathy.
|
24898870 |
2014 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our results indicate that inhibition of AR in HREC prevents tube formation by inhibiting the VEGF-induced activation of the Akt and p38-MAPK pathway and suggest a mediatory role of AR in ocular neovascularization generally implicated in retinopathy and AMD.
|
22658411 |
2013 |
|
Retinal Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
We used three mouse models of pathological ocular neovascularization: oxygen-induced retinopathy (a mouse model of ischemic retinopathies), laser-induced choroidal neovascularization, and a human VEGF transgenic mouse that overexpresses human VEGF specifically in photoreceptor cells and generates pathological neovascularization in the retina.
|
23195430 |
2013 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Retinas of oxygen-induced retinopathy mice (a model for PDR) had higher TCF7L2 and VEGFA mRNA levels than those of controls (P = 2.9E-04 for TCF7L2; P = 1.9E-07 for VEGFA).
|
23434931 |
2013 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In support of this, PGC-1α(-/-) mice subjected to oxygen-induced retinopathy had decreased expression of VEGFA and were protected against pathological neovascularization.
|
23141926 |
2013 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of 15-lipoxygenase-1 in oxygen-induced ischemic retinopathy inhibits retinal neovascularization via downregulation of vascular endothelial growth factor-A expression.
|
23233787 |
2012 |
|
Retinal Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Heparanase is involved in hypoxia-induced neovascularization through promoting VEGF expression and may be a new therapeutic target for hypoxia-induced neovascularization retinal diseases.
|
22956610 |
2012 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To determine the potential genotype differences in the vascular endothelial growth factor (VEGF) gene in diabetic patients, which might explain the difference in terms of the development of clinical vascular complications: great vessels atherosclerosis vs. retinopathy.
|
22064697 |
2012 |
|
Retinal Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The use of VEGF inhibitors for treatment of macular edema (due to radiation retinopathy) after irradiation of UM should be considered carefully, because of the possible adverse effects on residual UM cells.
|
23077404 |
2012 |