|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumors from patients with lymph node metastasis exhibited significantly lower Beclin 1 mRNA and protein expression levels compared with tumors from patients without lymph node involvement (P<0.05).
|
29163702 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrate that Beclin‑1 acts as a tumour suppressor in the development or progression of OTSCC and that Beclin‑1 may represent a novel prognostic marker for patients with OTSCC.
|
27356955 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the expressions of tumor inhibitor of growth (ING1) gene p33ING1, p53, and autophagy-related gene Beclin1 in human non-small cell lung cancer (NSCLC), and the correlation between their expressions with clinical pathological features and clinical significance.
|
21779982 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. <i>In vivo</i> study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.
|
31001120 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, genetic and pharmacological activation of the BECN1 pathway by overexpression of the protein in tumor cells or by administration of the BECN1 activator peptide Tat-beclin 1, respectively, increases ferroptotic cancer cell death (but not apoptosis and necroptosis) in vitro and in vivo in subcutaneous and orthotopic tumor mouse models.
|
30057310 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We took BECN1, a core gene in autophagy performing a tumor inhibitory effect, as a starting point.
|
28401970 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells.
|
30066884 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, when the tumor cell line was selected over a long period to achieve constitutive knock-down of Beclin 1, its sensitivity to proteasome inhibitors was no higher than that of the wild-type tumor cells.
|
22842577 |
2012 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Contrary to previous reports, BECN1 is not significantly mutated in human cancer and not a tumor-suppressor gene, as originally thought.
|
24478461 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 gene inhibits tumor growth in colon cancer cell lines.
|
17595761 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor.
|
17612932 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.
|
26357854 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of Beclin 1 was associated with pelvic lymph node metastasis and histological grade, but did not correlate with International Federation of Gynecology and Obstetrics stage, age, depth of cervical infiltration, tumor size, and gross type of cervical lesion.
|
21623196 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We examined the immunohistochemical expression of autophagy-related proteins, microtubule-associated proteins light chain 3β (LC3), beclin-1, and p62/sequestosome-1 (p62), as well as tumor suppressor gene product p53.
|
25466963 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association was observed between BRCA1 and BECN1 expression and tumor size (p=0.028 and p=0.021).
|
22011761 |
2012 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, the tumor volumes in subcutaneous nude mouse models in Beclin-1-deleted HOS cells were significantly smaller than those of control group.
|
25427639 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
|
23935917 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis and that Beclin-1 is a haploinsufficient tumor suppressor.
|
26239434 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data provide an explanation for how low levels of Beclin 1 facilitate tumor proliferation and contribute to poor cancer outcomes.
|
31744816 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The abnormal expression of Beclin-1 has recently been investigated in a variety of tumors.
|
30107804 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RNF216 promoted CRC cell proliferation and migration in vitro and in vivo, largely by enhancing proteasomal degradation of BECN1, a key autophagy regulator and tumor suppressor.
|
27203674 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, experimental evidence suggests that Beclin-1 inhibits tumor formation, angiogenesis, and metastasis alone and in cooperation with the tumor suppressive molecules UVRAG, Bif-1, Ambra1, and MDA-7/IL-24 via diverse mechanisms of action.
|
29405978 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that a prosurvival autophagic pathway is critical for CSC maintenance, and that Beclin 1 plays a dual role in tumor development.
|
22733132 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1 is an essential autophagy regulator and a haploinsufficient tumor-suppressor.
|
28479384 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Of the 271 patients, 229 (84.5%) were Beclin 1 high expression tumors by immunohistochemistry.
|
23029344 |
2012 |