|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein.
|
16540632 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 gene inhibits tumor growth in colon cancer cell lines.
|
17595761 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor.
|
17612932 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1, an important regulator of autophagy, acts as a tumor suppressor.
|
18495205 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 acts as a tumor suppressor and is an essential mediator of autophagy.
|
24535641 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1 (Becn1) is a putative tumor suppressor gene that has been shown to undergo a loss of heterozygosity in 40-75% of human breast, ovarian, and prostate cancers.
|
25246579 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Beclin1 and LC3 were highly expressed in oncocytes of Hürthle cell tumors.
|
26354775 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1 is an essential autophagy regulator and a haploinsufficient tumor-suppressor.
|
28479384 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
BECN1-knockout impairs tumor growth, migration and invasion by suppressing the cell cycle and partially suppressing the epithelial-mesenchymal transition of human triple-negative breast cancer cells.
|
30015871 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Beclin1 overexpression suppresses tumor cell proliferation and survival via an autophagy‑dependent pathway in human synovial sarcoma cells.
|
30066884 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 is involved in autophagy, differentiation, apoptosis and cancer progression, and functions as a haploinsufficient tumor suppressor gene.
|
30675309 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Beclin1 and ULK1 expressions and the LC3-II/LC3-I ratio in tumor tissues were altered by rapamycin, whereas mTOR, Notch1, CD133, and CD90 expressions were significantly inhibited by rapamycin in immunofluorescence assays.
|
30964118 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association was observed between BRCA1 and BECN1 expression and tumor size (p=0.028 and p=0.021).
|
22011761 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Additionally, autophagy markers LC3II/I (<i>p</i> < 0.05), Beclin-1 (<i>p</i> < 0.01), and P62 (<i>p</i> < 0.05) increased in the skeletal muscle of tumor-bearing mice.
|
30713500 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
AE also had anti-proliferative effects and induced the expression of the autophagic proteins beclin1 and LC3B-II in mouse xenograft tumors.
|
24133573 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism.
|
19524509 |
2009 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As a critical mediator, BECN1 influences the onset and advance of autophagy and several studies have pointed to the BECN1 recurrent allelic deletion and expression variation in a broad range of tumors.
|
26765290 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Autophagy can serve as a tumor suppressor, as a partial reduction in autophagic capacity or defective autophagy (e.g., heterozygous knockdown BECN1 (+/-) in mice) provides an oncogenic stimulus, causing malignant transformation and spontaneous tumors.
|
20224296 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Contrary to previous reports, BECN1 is not significantly mutated in human cancer and not a tumor-suppressor gene, as originally thought.
|
24478461 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of Beclin-1 and LC3-II was associated with lymph node metastasis of PTC (P<0.05), but had no association with age, gender, tumor size, tumor number and Tumor-Node-Metastasis stage (P>0.05).
|
28693184 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, upregulation of MIR34A, knockdown of HMGB1, or inhibition of autophagy (e.g., knockdown of ATG5 and BECN1) restores chemosensitivity and enhances tumor cell death in the retinoblastoma cell.
|
24418846 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For instance, Beclin-1 is negatively regulated by miRNA-376b (oncogenic miRNA) and miRNA-30a (tumor suppressor miRNA).
|
30784066 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, NS5ATP9-mediated autophagy is required for promotion of tumour cell growth, and this effect could be inhibited with 3-methyladenine, chloroquine or by Beclin 1-silencing.
|
25649430 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Genetic inactivation of Beclin-1, an autophagy regulator, significantly reverses mitochondrial abnormalities and tumor development in ATM-null mice, independently of DDR.
|
29616191 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF-2α and Beclin 1 were associated with histological grade and Musculoskeletal Tumor Society stage.
|
21327823 |
2011 |