|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Contrary to previous reports, BECN1 is not significantly mutated in human cancer and not a tumor-suppressor gene, as originally thought.
|
24478461 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, the tumor volumes in subcutaneous nude mouse models in Beclin-1-deleted HOS cells were significantly smaller than those of control group.
|
25427639 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
As a critical mediator, BECN1 influences the onset and advance of autophagy and several studies have pointed to the BECN1 recurrent allelic deletion and expression variation in a broad range of tumors.
|
26765290 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrate that Beclin‑1 acts as a tumour suppressor in the development or progression of OTSCC and that Beclin‑1 may represent a novel prognostic marker for patients with OTSCC.
|
27356955 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the expressions of tumor inhibitor of growth (ING1) gene p33ING1, p53, and autophagy-related gene Beclin1 in human non-small cell lung cancer (NSCLC), and the correlation between their expressions with clinical pathological features and clinical significance.
|
21779982 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, in the presence of AMPK activator AMPKinone, the protein level of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I increased, while the protein expression of p-AMPK, p-ULK1, Beclin-1 and LC3-II/LC3-I decreased in the presence of AMPK inhibitor Compound C. <i>In vivo</i> study using xenograft mice revealed that Zn-CuO NPs significantly inhibited tumor growth with low toxicity.
|
31001120 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, genetic and pharmacological activation of the BECN1 pathway by overexpression of the protein in tumor cells or by administration of the BECN1 activator peptide Tat-beclin 1, respectively, increases ferroptotic cancer cell death (but not apoptosis and necroptosis) in vitro and in vivo in subcutaneous and orthotopic tumor mouse models.
|
30057310 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We took BECN1, a core gene in autophagy performing a tumor inhibitory effect, as a starting point.
|
28401970 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, when the tumor cell line was selected over a long period to achieve constitutive knock-down of Beclin 1, its sensitivity to proteasome inhibitors was no higher than that of the wild-type tumor cells.
|
22842577 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 gene inhibits tumor growth in colon cancer cell lines.
|
17595761 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor.
|
17612932 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Via these biologic functions, Beclin 1 contributes to both tumor suppression and tumor progression.
|
26357854 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We examined the immunohistochemical expression of autophagy-related proteins, microtubule-associated proteins light chain 3β (LC3), beclin-1, and p62/sequestosome-1 (p62), as well as tumor suppressor gene product p53.
|
25466963 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
|
23935917 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In ovarian cancer, prevalent mono-allelic deletion of BECN1 (a canonical autophagy-inducer) suggests that autophagy is impaired to promote carcinogenesis and that Beclin-1 is a haploinsufficient tumor suppressor.
|
26239434 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
RNF216 promoted CRC cell proliferation and migration in vitro and in vivo, largely by enhancing proteasomal degradation of BECN1, a key autophagy regulator and tumor suppressor.
|
27203674 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall, experimental evidence suggests that Beclin-1 inhibits tumor formation, angiogenesis, and metastasis alone and in cooperation with the tumor suppressive molecules UVRAG, Bif-1, Ambra1, and MDA-7/IL-24 via diverse mechanisms of action.
|
29405978 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that a prosurvival autophagic pathway is critical for CSC maintenance, and that Beclin 1 plays a dual role in tumor development.
|
22733132 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1 is an essential autophagy regulator and a haploinsufficient tumor-suppressor.
|
28479384 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein.
|
16540632 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This protein could effectively transport Beclin 1 to breast and ovarian cancer cell lines under weakly acidic conditions (pH 6.5), markedly inhibit tumor cell growth and proliferation, and induce obvious autophagy.
|
29359549 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For instance, Beclin-1 is negatively regulated by miRNA-376b (oncogenic miRNA) and miRNA-30a (tumor suppressor miRNA).
|
30784066 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Subcutaneous xenograft nude mice model of human esophageal carcinoma was established, and the tumor growths in Beclin-1 group, control group and empty vector group were monitored.
|
31823702 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicated that at least some tumor suppressor functions of Beclin 1 were mediated through posttranscriptional regulation of ZEB1 via AUF1 in thyroid cancers.
|
27683118 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transfected MDA-MB-453 cells were inoculated into the right axilla of the nude mice, the tumor volume and weight were weighed, and the expression of miR-107, HMGB1, p62, and Beclin1 in the tumor were detected.
|
30506984 |
2018 |