|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1, the first identified mammalian autophagy gene product, is a haploinsufficient tumor suppressor that was originally isolated as a Bcl-2-interacting protein.
|
16540632 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results identify UVRAG as an essential component of the Beclin1-PI(3)KC3 lipid kinase complex that is an important signalling checkpoint for autophagy and tumour-cell growth.
|
16799551 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The BECN1 gene that encodes BECN1 protein acts as a haploinsufficient tumor-suppressor gene.
|
17550384 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 gene inhibits tumor growth in colon cancer cell lines.
|
17595761 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin 1 physically associates with Bcl-x(L) and is considered as a haploinsufficient tumor suppressor.
|
17612932 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor.
|
17891140 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Beclin1, an important regulator of autophagy, acts as a tumor suppressor.
|
18495205 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppression mechanism.
|
19524509 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We first evaluated the tumor cell cytoplasmic expression of Beclin 1 protein (BPCE), in a sample of 76 HGG by immunohistochemistry, and compared it with cell proliferation and apoptosis.
|
19556884 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Intratumoral DeltaPK injection (10(6)-10(7) plaque-forming unit (pfu)) significantly reduced melanoma tumor burden associated with calpain and caspases-7 and -3 activation, Beclin-1 and H11/HspB8 upregulation and activation of caspase-1-related inflammation.
|
19798049 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Autophagy can serve as a tumor suppressor, as a partial reduction in autophagic capacity or defective autophagy (e.g., heterozygous knockdown BECN1 (+/-) in mice) provides an oncogenic stimulus, causing malignant transformation and spontaneous tumors.
|
20224296 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIF-2α and Beclin 1 were associated with histological grade and Musculoskeletal Tumor Society stage.
|
21327823 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest a positive feedback loop for recruitment of FYVE-CENT and Beclin 1 to the intercellular bridge during cytokinesis, and reveal a novel potential tumor suppressor mechanism for Beclin 1.
|
21455500 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of Beclin 1 was associated with pelvic lymph node metastasis and histological grade, but did not correlate with International Federation of Gynecology and Obstetrics stage, age, depth of cervical infiltration, tumor size, and gross type of cervical lesion.
|
21623196 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the expressions of tumor inhibitor of growth (ING1) gene p33ING1, p53, and autophagy-related gene Beclin1 in human non-small cell lung cancer (NSCLC), and the correlation between their expressions with clinical pathological features and clinical significance.
|
21779982 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA and protein expressions of Beclin1 and Bcl-2 in breast cancer tissues were significantly lower than those in the relatively healthy, adjacent breast tissues (p < 0.05); the lower the degree of tumor differentiation, the lower the mRNA and protein expressions of Beclin1 and Bcl-2 (p < 0.05); the mRNA and protein expressions of Beclin1 and Bcl-2 in breast cancer tissues from patients positive for lymph node metastasis were significantly lower than those negative for lymph node metastasis (p < 0.05); the mRNA and protein expressions of Beclin1 and Bcl-2 in breast cancer tissues from patients positive for distant metastasis were significantly lower than those negative for distant metastasis (p < 0.05); the mRNA and protein expressions of Beclin1 and Bcl-2 in breast cancer tissues from patients positive for ki67 were significantly lower than those negative for ki67 (p < 0.05).
|
21861179 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A significant association was observed between BRCA1 and BECN1 expression and tumor size (p=0.028 and p=0.021).
|
22011761 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Upregulation of pro-apoptotic BAX and downregulation of anti-apoptotic BCL2 and SURVIVIN genes were observed in all three cancer cell lines and additionally the autophagy genes (ATG5, ATG7, and BECLIN1) were upregulated in MG-63 cells. hWJSCs possess tumor inhibitory properties that are not specific to breast cancer cells alone and these effects are mediated via agents in its extracts.
|
22275115 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The immunohistochemical expression of Beclin 1 and LC3 were evaluated in 26 formalin-fixed paraffin-embedded cervical normal tissue samples and 50 tumor samples of FIGO stage I-II cervical squamous cell carcinoma, respectively.
|
22648564 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study demonstrates that a prosurvival autophagic pathway is critical for CSC maintenance, and that Beclin 1 plays a dual role in tumor development.
|
22733132 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, when the tumor cell line was selected over a long period to achieve constitutive knock-down of Beclin 1, its sensitivity to proteasome inhibitors was no higher than that of the wild-type tumor cells.
|
22842577 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Of the 271 patients, 229 (84.5%) were Beclin 1 high expression tumors by immunohistochemistry.
|
23029344 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In INS-GAS mice, ATG-5 and beclin-1 were positive in the tumor area, but the numbers of immunopositive cells per gland were reduced by about 50% in comparison with wild-type mice.
|
23389729 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The autophagic genes beclin-1 and LC3 paly an important role in the development and progression of tumor.
|
23935917 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In NSCLC tumor xenografts, the expression of a tyrosine phosphomimetic Beclin 1 mutant leads to reduced autophagy, enhanced tumor growth, tumor dedifferentiation, and resistance to TKI therapy.
|
24034250 |
2013 |