Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2675519
Disease: Hypoadiponectinemia
Hypoadiponectinemia 		0.500 CausalMutation disease CLINVAR
CUI: C2675519
Disease: Hypoadiponectinemia
Hypoadiponectinemia 		0.500 Biomarker disease CTD_human
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency 		0.370 Biomarker disease CTD_human
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE These characteristics make APM-1, the first novel human gene identified in a HPV integration region, a likely candidate for the postulated tumour suppressor gene. 9427755 1998
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 AlteredExpression disease BEFREE APM-1 transcripts are detected in normal cervical keratinocytes, but not in the majority of cervical carcinoma cell lines analysed. 9427755 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker disease BEFREE The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue and seems to play a role in the pathogenesis of obesity. 9765595 1998
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker disease CTD_human Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. 10092513 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Therapeutic disease CTD_human Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. 10092513 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker disease BEFREE Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue. 10092513 1999
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.600 GeneticVariation disease BEFREE The chromosomal localization of apM-1 was investigated by FISH and mapped to human chromosome 1q21.3-1q23, a region that was identified as a susceptibility locus for Familial Combined Hyperlipidaemia (FCH) and polygenic NIDDM. 10403784 1999
CUI: C0028754
Disease: Obesity
Obesity 		0.600 Biomarker disease BEFREE The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue that has been suggested to play a role in the pathogenesis of obesity. 10403784 1999
CUI: C0020474
Disease: Hyperlipidemia, Familial Combined
Hyperlipidemia, Familial Combined 		0.040 GeneticVariation disease BEFREE The chromosomal localization of apM-1 was investigated by FISH and mapped to human chromosome 1q21.3-1q23, a region that was identified as a susceptibility locus for Familial Combined Hyperlipidaemia (FCH) and polygenic NIDDM. 10403784 1999
CUI: C0948242
Disease: Nuchal bleb, familial
Nuchal bleb, familial 		0.020 Biomarker disease BEFREE These data and the chromosomal localization on chromosome 1q21.3-q23 raises the possibility that apM-1 as an adipocyte-specific secretory protein may play a role in the pathogenesis of FCH and associated insulin resistance. 10403784 1999
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 Biomarker disease BEFREE Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. 10604883 2000
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 Biomarker disease BEFREE Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. 10604883 2000
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 Biomarker disease BEFREE Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects. 10604883 2000
CUI: C2675517
Disease: ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 		0.300 GeneticVariation phenotype UNIPROT Genomic structure and mutations in adipose-specific gene, adiponectin. 10918532 2000
CUI: C0023479
Disease: Acute myelomonocytic leukemia
Acute myelomonocytic leukemia 		0.010 Biomarker disease BEFREE At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. 10961870 2000
CUI: C0279627
Disease: Adult Acute Myelomonocytic Leukemia
Adult Acute Myelomonocytic Leukemia 		0.010 Biomarker disease BEFREE At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. 10961870 2000
CUI: C0279644
Disease: Childhood Acute Myelomonocytic Leukemia
Childhood Acute Myelomonocytic Leukemia 		0.010 Biomarker disease BEFREE At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation. 10961870 2000
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.100 GeneticVariation group BEFREE Well defined cohorts of patients are necessary to determine the putative role of apM-1 gene mutations in the pathogenesis of metabolic disorders. 11029602 2000
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18. 11304690 2001
CUI: C0025286
Disease: Meningioma
Meningioma 		0.010 Biomarker disease BEFREE Taken together, our data do not support a significant role for MADH2, MADH4, APM-1 and DCC alterations in the pathogenesis of meningiomas. 11304690 2001
CUI: C0431122
Disease: Atypical meningioma
Atypical meningioma 		0.010 GeneticVariation disease BEFREE Mutation analysis of APM-1 revealed a missense mutation (c. 1819G>A: G607S) in 1 atypical meningioma. 11304690 2001
CUI: C1332184
Disease: Adult Atypical Meningioma
Adult Atypical Meningioma 		0.010 GeneticVariation disease BEFREE Mutation analysis of APM-1 revealed a missense mutation (c. 1819G>A: G607S) in 1 atypical meningioma. 11304690 2001