|
Hypoadiponectinemia
|
0.500 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Hypoadiponectinemia
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Adiponectin Deficiency
|
0.370 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue and seems to play a role in the pathogenesis of obesity.
|
9765595 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These characteristics make APM-1, the first novel human gene identified in a HPV integration region, a likely candidate for the postulated tumour suppressor gene.
|
9427755 |
1998 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
APM-1 transcripts are detected in normal cervical keratinocytes, but not in the majority of cervical carcinoma cell lines analysed.
|
9427755 |
1998 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal localization of apM-1 was investigated by FISH and mapped to human chromosome 1q21.3-1q23, a region that was identified as a susceptibility locus for Familial Combined Hyperlipidaemia (FCH) and polygenic NIDDM.
|
10403784 |
1999 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
CTD_human |
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
|
10092513 |
1999 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human adipocyte-specific apM-1 gene encodes a secretory protein of the adipose tissue that has been suggested to play a role in the pathogenesis of obesity.
|
10403784 |
1999 |
|
Obesity
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.
|
10092513 |
1999 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Plasma concentrations of adiponectin in obese subjects were significantly lower than those in non-obese subjects, although adiponectin is secreted only from adipose tissue.
|
10092513 |
1999 |
|
Hyperlipidemia, Familial Combined
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal localization of apM-1 was investigated by FISH and mapped to human chromosome 1q21.3-1q23, a region that was identified as a susceptibility locus for Familial Combined Hyperlipidaemia (FCH) and polygenic NIDDM.
|
10403784 |
1999 |
|
Nuchal bleb, familial
|
0.020 |
Biomarker
|
disease |
BEFREE |
These data and the chromosomal localization on chromosome 1q21.3-q23 raises the possibility that apM-1 as an adipocyte-specific secretory protein may play a role in the pathogenesis of FCH and associated insulin resistance.
|
10403784 |
1999 |
|
ADIPONECTIN, SERUM LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
|
0.300 |
GeneticVariation
|
phenotype |
UNIPROT |
Genomic structure and mutations in adipose-specific gene, adiponectin.
|
10918532 |
2000 |
|
Coronary Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects.
|
10604883 |
2000 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects.
|
10604883 |
2000 |
|
Metabolic Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Well defined cohorts of patients are necessary to determine the putative role of apM-1 gene mutations in the pathogenesis of metabolic disorders.
|
11029602 |
2000 |
|
Coronary Artery Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma adiponectin concentrations were significantly lower in patients with coronary artery disease than those in age- and body mass index-adjusted control subjects.
|
10604883 |
2000 |
|
Acute myelomonocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation.
|
10961870 |
2000 |
|
Adult Acute Myelomonocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation.
|
10961870 |
2000 |
|
Childhood Acute Myelomonocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At least one mechanism of the growth inhibition is induction of apoptosis because treatment of acute myelomonocytic leukemia lines with adiponectin induced the appearance of subdiploid peaks and oligonucleosomal DNA fragmentation.
|
10961870 |
2000 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Prospective longitudinal studies revealed that the plasma levels of adiponectin declined at an early phase of obesity and remained decreased after the development of type 2 diabetes.
|
11334417 |
2001 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This regulation could contribute to the decreased apM1/ApN levels in insulin-resistant patients with obesity and the Metabolic Syndrome.
|
11700024 |
2001 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recently described mutations within the human adipocyte-specific apM-1 gene might play a role in the pathogenesis of obesity, type 2 diabetes and related metabolic disorders.
|
11571669 |
2001 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.
|
11549668 |
2001 |