Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2675519
Disease: Hypoadiponectinemia
Hypoadiponectinemia
0.500 CausalMutation disease CLINVAR
CUI: C2675519
Disease: Hypoadiponectinemia
Hypoadiponectinemia
0.500 Biomarker disease CTD_human
CUI: C2675518
Disease: Adiponectin Deficiency
Adiponectin Deficiency
0.370 Biomarker disease CTD_human
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE <b>Background:</b> Adiponectin has been suggested as a marker of many cardiovascular diseases. 31088901 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE <b>Background:</b> Insulin, IGF axis, adiponectin, and inflammatory markers are associated with breast cancer. 27742668 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.100 Biomarker disease BEFREE <b>Background:</b> Insulin, IGF axis, adiponectin, and inflammatory markers are associated with breast cancer. 27742668 2017
CUI: C0028754
Disease: Obesity
Obesity
0.600 Biomarker disease BEFREE <b>Background:</b> Studies examining associations between circulating concentrations of C-peptide and total adiponectin, two biomarkers related to obesity and insulin secretion and sensitivity and pancreatic ductal adenocarcinoma (PDA) risk have shown inconsistent results and included limited numbers of smokers.<b>Methods:</b> We examined associations of these biomarkers and high molecular weight (HMW) adiponectin with PDA, overall, and by smoking status. 28096201 2017
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma
0.010 Biomarker disease BEFREE <b>Background:</b> Studies examining associations between circulating concentrations of C-peptide and total adiponectin, two biomarkers related to obesity and insulin secretion and sensitivity and pancreatic ductal adenocarcinoma (PDA) risk have shown inconsistent results and included limited numbers of smokers.<b>Methods:</b> We examined associations of these biomarkers and high molecular weight (HMW) adiponectin with PDA, overall, and by smoking status. 28096201 2017
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.050 AlteredExpression phenotype BEFREE <b>Background:</b> Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise (<i>n</i> = 109) to a placebo control condition (<i>n</i> = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression.<b>Methods:</b> Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months. 29141853 2018
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE <b>Conclusion</b>: Low circulating adiponectin could be a predictive or risk factor for RCC. 31215811 2019
Conventional (Clear Cell) Renal Cell Carcinoma
0.400 GeneticVariation disease BEFREE <b>Conclusion</b>: Low circulating adiponectin could be a predictive or risk factor for RCC. 31215811 2019
CUI: C0028754
Disease: Obesity
Obesity
0.600 GeneticVariation disease BEFREE <b>Conclusion:</b> Adiponectin rs1501299 polymorphism might be a candidate gene, which determines the susceptibility to obesity. 31502880 2019
CUI: C0007820
Disease: Cerebrovascular Disorders
Cerebrovascular Disorders
0.030 AlteredExpression group BEFREE <b>Conclusion:</b> According to the novel study, it was suggested that elevated serum leptin as well as visfatin and decreased adiponectin levels may be a sign of cerebrovascular disease and as part of the response occurring in stroke patients. 30892950 2019
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease
0.100 Biomarker disease BEFREE <b>Conclusion:</b> Elevated levels of CTRP15 in CAD patients and the relation of CTRP15 with pathogenic conditions such as insulin resistance, inflammation, and decreased adiponectin and HDL-C suggest a possible compensatory response to these conditions in CAD patients. 31608708 2019
CUI: C0018801
Disease: Heart failure
Heart failure
0.400 AlteredExpression disease BEFREE <b>Methods:</b> Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for <i>de novo</i> HF (n=74). 29559829 2018
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure
0.400 AlteredExpression disease BEFREE <b>Methods:</b> Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for <i>de novo</i> HF (n=74). 29559829 2018
CUI: C0400966
Disease: Non-alcoholic Fatty Liver Disease
Non-alcoholic Fatty Liver Disease
0.400 AlteredExpression disease BEFREE <b>Methods:</b> A total of 203 children and adolescents aged 5-18 years were enrolled, and their anthropometric data, body composition, liver ultrasound score for NAFLD (range, 0-6), biochemical test results, and FGF-21, leptin, and adiponectin levels were analyzed. 31750276 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression group BEFREE (1) Serum adiponectin levels were negatively correlated with numerous CVD risk factors (all P<0.05), and following adjustments for confounding factors, a lower adiponectin level was an independent risk factor for MetS (odds ratio=5.59; 95% confidence interval: 1.90, 16.41). 25074391 2015
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.100 AlteredExpression disease BEFREE (https://doi.org/10.1084/jem.20181288) identify reduced adiponectin levels as responsible for the increased incidence of HCC in males. 31000682 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.400 Biomarker disease BEFREE 1897 participants enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin-6 (IL-6), C-reactive protein (CRP), and resistin. 30213651 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.100 Biomarker disease BEFREE 1897 participants enrolled in the Multi-Ethnic Study of Atherosclerosis underwent computed tomography to quantify body composition and measurements of adiponectin, leptin, interleukin-6 (IL-6), C-reactive protein (CRP), and resistin. 30213651 2019
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus
0.400 AlteredExpression group BEFREE 2) In contrast to previous studies, the presence of diabetes does not influence adiponectin serum levels after correction for BMI. 15239024 2004
CUI: C0011847
Disease: Diabetes
Diabetes
0.100 AlteredExpression disease BEFREE 2) In contrast to previous studies, the presence of diabetes does not influence adiponectin serum levels after correction for BMI. 15239024 2004
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36.5; 37.9 and 39.5 cm; women: 31.4; 32.5 and 34 cm) and traditional and non-traditional risk factors (lipoprotein subfractions by Vertical Auto Profile, adiponectin, leptin, E-selectin) were compared across groups. 30479668 2018
CUI: C2675519
Disease: Hypoadiponectinemia
Hypoadiponectinemia
0.500 GeneticVariation disease BEFREE Hypoadiponectinemia is associated with progression toward type 2 diabetes and genetic variation in the ADIPOQ gene promoter. 16801592 2006