GDF15, growth differentiation factor 15, 9518

N. diseases: 389; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1961099
Disease: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 		0.010 GeneticVariation disease BEFREE The segment encompasses MIC1, a recurrent translocation breakpoint in acute T-cell leukemia (TCL2), and most or all of the WAGR gene complex, but does not include the close flanking markers D11S16 and delta J. 2154397 1990
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE These results provide the first evidence for a direct functional link between p53 and the TGF-beta superfamily and implicate PTGF-beta as an important intercellular mediator of p53 function and the cytostatic effects of radiation and chemotherapeutic cancer agents. 10777512 2000
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker group BEFREE These results provide the first evidence for a direct functional link between p53 and the TGF-beta superfamily and implicate PTGF-beta as an important intercellular mediator of p53 function and the cytostatic effects of radiation and chemotherapeutic cancer agents. 10777512 2000
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE GDF-15/MIC-1 may therefore have a potential for the treatment of Parkinson's disease and disorders of the serotonergic system. 11102463 2000
CUI: C0742468
Disease: Central nervous system lesion
Central nervous system lesion 		0.010 AlteredExpression disease BEFREE Finally, GDF-15/MIC-1 may also act within the antiinflammatory cytokine network activated in CNS lesions. 11579380 2001
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.100 Biomarker group BEFREE Of these women, we established baseline concentrations of MIC-1 in 257 who subsequently had myocardial infarction, stroke, or died from a cardiovascular event (cases) and in 257 matched for age and smoking status, who did not report cardiovascular disease during 4-year follow-up (controls). 12090982 2002
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker disease BEFREE Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. 12082608 2002
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.100 Biomarker disease LHGDN Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. 12082608 2002
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.100 Biomarker disease BEFREE Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. 12082608 2002
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.090 Biomarker disease BEFREE Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. 12082608 2002
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.090 Biomarker disease BEFREE Oxygen deprivation, an important cellular stress, revealed MIC-1 as an anoxia responsive gene in glioblastoma cell lines. 12082608 2002
CUI: C3845502
Disease: Myocardial infarction, stroke
Myocardial infarction, stroke 		0.020 Biomarker disease BEFREE Of these women, we established baseline concentrations of MIC-1 in 257 who subsequently had myocardial infarction, stroke, or died from a cardiovascular event (cases) and in 257 matched for age and smoking status, who did not report cardiovascular disease during 4-year follow-up (controls). 12090982 2002
CUI: C1963943
Disease: Atherothrombosis
Atherothrombosis 		0.010 Biomarker disease BEFREE We aimed to investigate whether MIC-1 has a role in atherothrombosis. 12090982 2002
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 AlteredExpression phenotype BEFREE Serum MIC-1 level was correlated with the extent of disease so that the levels were higher in patients with higher Tumor-Node-Metastasis stage. 12855642 2003
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 AlteredExpression disease BEFREE The expression of the MIC-1 gene in prostate cancer is significantly higher than in noncancerous tissues, especially in more aggressive forms of the disease (Gleason score>5). 12671711 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.370 Biomarker group LHGDN Macrophage inhibitory cytokine 1 reduces cell adhesion and induces apoptosis in prostate cancer cells. 12941831 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE MIC-1 was expressed in CRC tissue and the cancer cell line CaCo-2. 12855642 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE Here, we show that the transforming growth factor-beta superfamily cytokine, macrophage inhibitory cytokine-1 (MIC-1), can serve as a secreted biomarker for activation of p53 in both cellular and xenograft models of human cancer. 14578467 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 AlteredExpression disease BEFREE There was a progressive increase in serum MIC-1 levels between normal individuals [mean (M) = 495 pg/ml, SD = 210), those with adenomatous polyps (M = 681 pg/ml, SD = 410), and those with CRC (M = 783 pg/ml, SD = 491)]. 12855642 2003
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.100 Biomarker disease BEFREE We show that several of the other candidate genes encode proteins with high levels of tumor-associated expression by immunohistochemistry on tissue microarrays and further demonstrate significantly elevated levels of another novel candidate protein, macrophage inhibitory cytokine 1, a distant member of the transforming growth factor-beta superfamily, in the serum of patients with metastatic prostate, breast, and colorectal carcinomas. 12624183 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE When transplanted into nude mice, HCT116 cells continued to secret human MIC-1 and mouse plasma levels correlated well with tumor volume. 14578467 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Studies have demonstrated a growth-inhibiting effect of MIC-1/GDF-15 on colon and breast cancer cell lines in vitro and on tumor growth in vivo. 14592665 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE We show that several of the other candidate genes encode proteins with high levels of tumor-associated expression by immunohistochemistry on tissue microarrays and further demonstrate significantly elevated levels of another novel candidate protein, macrophage inhibitory cytokine 1, a distant member of the transforming growth factor-beta superfamily, in the serum of patients with metastatic prostate, breast, and colorectal carcinomas. 12624183 2003
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 AlteredExpression group BEFREE This study examines the relationship of serum MIC-1 levels and genotypes to clinical and pathologic features of colonic neoplasia. 12855642 2003
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.100 AlteredExpression phenotype BEFREE This study identifies a strong association between MIC-1 serum levels and neoplastic progression within the large bowel. 12855642 2003