|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background and Aims:</b> Growth differentiation factor-15 (GDF-15) has been identified as a robust marker of developing cardiovascular disease, however, little is currently known about its prognostic value in stroke patients.
|
31258506 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
<b>Background:</b> Recent studies have shown that growth differentiation factor 15 (GDF15), a member of the transforming growth factor-β (TGF-β)/bone morphogenetic protein (BMP) superfamily, plays an important role in appetite, type 2 diabetes, and cardiovascular diseases.
|
30687235 |
2018 |
|
Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> GDF15 might be a novel regulator of PD-L1 expression in GBMs; targeting GDF15/PD-L1 pathway might be a promising therapeutic approach for GBM patients.
|
31114328 |
2019 |
|
Glioblastoma Multiforme
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Conclusion:</b> GDF15 might be a novel regulator of PD-L1 expression in GBMs; targeting GDF15/PD-L1 pathway might be a promising therapeutic approach for GBM patients.
|
31114328 |
2019 |
|
Nausea and vomiting
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Methods</b> We compared serum levels of GDF15 and IGFBP7 at 12 and 24 weeks' gestation in women hospitalized for HG, and two control groups, women with nausea and vomiting of pregnancy (NVP), and women with no NVP.
|
31000883 |
2019 |
|
Hyperemesis Gravidarum
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results</b> Single nucleotide polymorphisms (SNPs) linked to higher levels of GDF15 segregated with disease in HG families.
|
30258246 |
2018 |
|
Hyperemesis Gravidarum
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
<b>Results</b> We show GDF15 and IGFBP7 serum levels are significantly increased in women with HG at 12 weeks' gestation.
|
31000883 |
2019 |
|
Androgen-Insensitivity Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Serum GDF-15 level at admission was significantly higher in AIS patients than in controls (<i>p</i> < .01).
|
31446824 |
2019 |
|
Extensively Drug-Resistant Tuberculosis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
0.015μg/mL) had a stronger bactericidal effect against the XDR-TB clinical isolate than DEL alone at 1×MIC (i.e.0.125μg/mL).
|
31226332 |
2019 |
|
Diabetes
|
0.100 |
Biomarker
|
disease |
BEFREE |
12 weeks after the diabetes induction, the rats with NRG-1 treatment were treated with tail vein injection of NRG-1 at the dose of 10µg/kg/d for consecutive 10 days.
|
29742506 |
2018 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
12 weeks after the diabetes induction, the rats with NRG-1 treatment were treated with tail vein injection of NRG-1 at the dose of 10µg/kg/d for consecutive 10 days.
|
29742506 |
2018 |
|
Malignant neoplasm of prostate
|
0.400 |
Biomarker
|
disease |
BEFREE |
2-5A also potently elevated RNA for macrophage inhibitory cytokine-1/nonsteroidal antiinflammatory drug-activated gene-1, a TGF-beta superfamily member implicated as an apoptotic suppressor of prostate cancer.
|
16203993 |
2005 |
|
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
2-5A also potently elevated RNA for macrophage inhibitory cytokine-1/nonsteroidal antiinflammatory drug-activated gene-1, a TGF-beta superfamily member implicated as an apoptotic suppressor of prostate cancer.
|
16203993 |
2005 |
|
Cerebrovascular accident
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Stroke/TIA in women was associated with GDF15/MIC-1 GG genotype (OR 3.75, 95% CI 1.06-13.33), while stroke/TIA in men was associated with CD40 homozygous major alleles (OR 6.48, 95% CI 1.31-32.0 and OR 2.78, 95% CI 0.78-9.91, respectively).
|
22505696 |
2012 |
|
Mitochondrial Myopathies
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Mitochondrial myopathy (MM) is the most common manifestation of adult-onset mitochondrial disease and shows a multifaceted tissue-specific stress response: (1) transcriptional response, including metabolic cytokines FGF21 and GDF15; (2) remodeling of one-carbon metabolism; and (3) mitochondrial unfolded protein response.
|
28768179 |
2017 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MIC-1 was expressed in CRC tissue and the cancer cell line CaCo-2.
|
12855642 |
2003 |
|
Primary malignant neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MIC-1 was expressed in CRC tissue and the cancer cell line CaCo-2.
|
12855642 |
2003 |
|
Carcinoma of bladder
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
MIC-1 gene down-regulation was observed in 16 of 25 symptomatic BPH samples (64.0%), whereas MIC-1 mRNA was high in 6 of 6 prostate adenoma samples from patients with bladder cancer (p = 0.0006).
|
15126815 |
2004 |
|
Malignant neoplasm of urinary bladder
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MIC-1 gene down-regulation was observed in 16 of 25 symptomatic BPH samples (64.0%), whereas MIC-1 mRNA was high in 6 of 6 prostate adenoma samples from patients with bladder cancer (p = 0.0006).
|
15126815 |
2004 |
|
Bladder Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
MIC-1 gene down-regulation was observed in 16 of 25 symptomatic BPH samples (64.0%), whereas MIC-1 mRNA was high in 6 of 6 prostate adenoma samples from patients with bladder cancer (p = 0.0006).
|
15126815 |
2004 |
|
Benign Prostatic Hyperplasia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
MIC-1 gene down-regulation was found in only 1 of 7 BPH samples with a glandular predominant pattern, whereas it was found in 15 of 24 BPH samples with a mixed type or stromal predominant pattern (p = 0.0373).
|
15126815 |
2004 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor beta superfamily, is involved in cellular processes such as inflammation, apoptosis/survival, and tumorigenesis and is regulated by p53, Sp1, and Egr-1.
|
15757899 |
2005 |
|
Malignant neoplasm of stomach
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-beta superfamily, which is overexpressed in a variety of human cancers, including breast and gastric cancer.
|
18258606 |
2008 |
|
Stomach Carcinoma
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Macrophage inhibitory cytokine-1 (MIC-1) is a member of the transforming growth factor-beta superfamily, which is overexpressed in a variety of human cancers, including breast and gastric cancer.
|
18258606 |
2008 |
|
Carcinogenesis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor-beta superfamily, is involved in many cellular processes, such as inflammation, apoptosis/survival, and tumorigenesis.
|
18413810 |
2008 |