|
Malignant neoplasm of breast
|
0.360 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Squamous cell carcinoma of esophagus
|
0.300 |
GeneticVariation
|
disease |
ORPHANET |
Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3.
|
10213508 |
1999 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors.
|
17016643 |
2006 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
The human DLC-1 (deleted in liver cancer 1) gene was cloned from a primary human hepatocellular carcinoma (HCC) and mapped to the chromosome 8p21-22 region frequently deleted in common human cancers and suspected to harbor tumor suppressor genes.
|
12545165 |
2003 |
|
Malignant Neoplasms
|
0.080 |
GeneticVariation
|
group |
BEFREE |
Since inactivation of tumor suppressor genes in cancer cells is also commonly associated with point mutation, we evaluated the incidence of mutation of the DLC-1 gene by PCR-SSCP in 17 primary HCC and 18 HCC cell lines.
|
12792785 |
2003 |
|
Adult Liver Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth.
|
14661059 |
2004 |
|
Adult Liver Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC).
|
11118037 |
2000 |
|
Adult Liver Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Further, the miRNA-target gene network analysis displayed that the deleted in liver cancer (DLC-1) gene, an important negative regulator for cell motility, was potentially targeted by several differentially expressed miRNAs in HBc-introduced cells.
|
28982593 |
2018 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC).
|
11118037 |
2000 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth.
|
14661059 |
2004 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Further, the miRNA-target gene network analysis displayed that the deleted in liver cancer (DLC-1) gene, an important negative regulator for cell motility, was potentially targeted by several differentially expressed miRNAs in HBc-introduced cells.
|
28982593 |
2018 |
|
Malignant neoplasm of liver
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
The deleted in liver cancer (DLC-1) gene at chromosome 8p21-22 is altered mainly by genomic deletion or aberrant promoter methylation in a large number of human cancers such as breast, liver, colon and prostate and is known to have an inhibitory effect on breast and liver tumor cell growth.
|
14661059 |
2004 |
|
Malignant neoplasm of liver
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We investigated the expression and deletion of DLC-1 (frequently deleted in liver cancer gene), first reported in 1998 and having a high homology with rat p122RhoGAP in hepatocellular carcinoma (HCC).
|
11118037 |
2000 |
|
Malignant neoplasm of liver
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Further, the miRNA-target gene network analysis displayed that the deleted in liver cancer (DLC-1) gene, an important negative regulator for cell motility, was potentially targeted by several differentially expressed miRNAs in HBc-introduced cells.
|
28982593 |
2018 |
|
Primary malignant neoplasm
|
0.060 |
GeneticVariation
|
group |
BEFREE |
Since inactivation of tumor suppressor genes in cancer cells is also commonly associated with point mutation, we evaluated the incidence of mutation of the DLC-1 gene by PCR-SSCP in 17 primary HCC and 18 HCC cell lines.
|
12792785 |
2003 |
|
Nasopharyngeal carcinoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
The DLC-1 -29A/T polymorphism is not associated with nasopharyngeal carcinoma risk in Chinese population.
|
18627284 |
2008 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Partial (1%-10%) and extensive (10%-100%) DLC-1 promoter methylations were observed in 10% and 0% of normal mucosa, 46% and 14% of adenomas, and 60% and 36% of CRCs, respectively.
|
23509688 |
2013 |
|
Malignant neoplasm of prostate
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that hypermethylation is responsible for abrogating the function of the DLC-1 gene in a subset of liver, breast, colon, and prostate cancers.
|
12645648 |
2003 |
|
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genomic deletion of DLC-1 was observed in 40% of primary breast tumors, whereas reduced or undetectable levels of DLC-1 mRNA were seen in 70% of breast, 70% of colon, and 50% of prostate tumor cell lines To see whether DLC-1 expression affects cell growth and tumorigenicity, two breast carcinoma cell lines lacking the expression of endogenous gene were transfected with the DLC-1 cDNA.
|
12545165 |
2003 |
|
Adenoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Partial (1%-10%) and extensive (10%-100%) DLC-1 promoter methylations were observed in 10% and 0% of normal mucosa, 46% and 14% of adenomas, and 60% and 36% of CRCs, respectively.
|
23509688 |
2013 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
Our results indicate a role of DLC-1 in BC carcinogenesis.
|
12759748 |
2003 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells.
|
16024604 |
2005 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
These findings are consistent with a possible tumour suppressor function of DLEC1 in breast cancer.
|
20530412 |
2010 |
|
Malignant neoplasm of breast
|
0.360 |
Biomarker
|
disease |
BEFREE |
Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene.
|
12545165 |
2003 |
|
Chest Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|